Pyrrolo-isoquinoline and glycosylated pyrrolidine alkaloids from Nigella glandulifera and their anti-PTP1B activity
Chen, QB (Chen, Qi-Bin); Xin, XL (Xin, Xue-Lei); Aisa, HA (Aisa, Haji Akber); Aisa, HA
2017
发表期刊PHYTOCHEMISTRY LETTERS
卷号19期号:3页码:168-171
摘要Two new alkaloids, nigellisoquinomine (1) with a novel pyrrolo-isoquinoline skeleton, and nigellapyrrolidine (2) possessing a rare glycosylated pyrrolidine moiety, together with two known alkaloids, agrocybenine (3) and 4,6,6-trimethyl-3,4-epoxypiperidin-2-one (4), were isolated from the seeds of Nigella glandulifera Freyn. Their structures were identified by extensive NMR and HR-ESIMS analysis. Compound 1 exhibited potent protein tyrosine phosphatase 1B (PTP1B) inhibitory activity with an IC50 value of 3.65 +/- 0.08 mu M.
关键词Alkaloids Pyrrolo-isoquinoline Alkaloids Glycosylated Pyrrolidine Alkaloids Nigella Glandulifera Anti-ptp1b Activity
DOI10.1016/j.phytol.2016.12.024
收录类别SCI
WOS记录号WOS:000397455800032
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被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.xjipc.cas.cn/handle/365002/4786
专题省部共建新疆特有药用资源利用重点实验室
通讯作者Aisa, HA
作者单位1.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Peoples R China
2.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Basis Xinjiang Indigenous Med Plant, Urumqi 830011, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100039, PR, Peoples R China
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Chen, QB ,Xin, XL ,Aisa, HA ,et al. Pyrrolo-isoquinoline and glycosylated pyrrolidine alkaloids from Nigella glandulifera and their anti-PTP1B activity[J]. PHYTOCHEMISTRY LETTERS,2017,19(3):168-171.
APA Chen, QB ,Xin, XL ,Aisa, HA ,&Aisa, HA.(2017).Pyrrolo-isoquinoline and glycosylated pyrrolidine alkaloids from Nigella glandulifera and their anti-PTP1B activity.PHYTOCHEMISTRY LETTERS,19(3),168-171.
MLA Chen, QB ,et al."Pyrrolo-isoquinoline and glycosylated pyrrolidine alkaloids from Nigella glandulifera and their anti-PTP1B activity".PHYTOCHEMISTRY LETTERS 19.3(2017):168-171.
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