Synthesis of Rupestonic Acid Derivatives with Antiviral Activity
Zhao, JY (Zhao, Jiangyu); Niu, C (Niu, Chao); Li, G (Li, Gen); Aisa, HA (Aisa, Haji Akber); Aisa, HA
2017
发表期刊CHEMISTRY OF NATURAL COMPOUNDS
卷号53期号:2页码:276-283
摘要A series of 23 new rupestonic acid derivatives were synthesized. Their activities against influenza viruses A (H3N2, H1N1) and B were studied. Compounds 2d and 2g demonstrated potent activity against influenza virus A (H3N2) with IC50 values of 0.35 and 0.21 mu M, respectively. Compound 5g (n = 10) was the most potent compound of this series against influenza viruses H3N2 and H1N1 with IC50 values of 2.89 and 0.38 mu M. Several of the synthesized compounds were weakly active against influenza virus B and were more toxic than starting rupestonic acid.
DOI10.1007/s10600-017-1970-y
收录类别SCI
WOS记录号WOS:000400195700017
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文献类型期刊论文
条目标识符http://ir.xjipc.cas.cn/handle/365002/4783
专题省部共建新疆特有药用资源利用重点实验室
通讯作者Aisa, HA
作者单位1.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Peoples R China
2.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Basis Xinjiang Indigenous Med Plant, Urumqi 830011, Peoples R China
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Zhao, JY ,Niu, C ,Li, G ,et al. Synthesis of Rupestonic Acid Derivatives with Antiviral Activity[J]. CHEMISTRY OF NATURAL COMPOUNDS,2017,53(2):276-283.
APA Zhao, JY ,Niu, C ,Li, G ,Aisa, HA ,&Aisa, HA.(2017).Synthesis of Rupestonic Acid Derivatives with Antiviral Activity.CHEMISTRY OF NATURAL COMPOUNDS,53(2),276-283.
MLA Zhao, JY ,et al."Synthesis of Rupestonic Acid Derivatives with Antiviral Activity".CHEMISTRY OF NATURAL COMPOUNDS 53.2(2017):276-283.
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