XJIPC OpenIR  > 省部共建新疆特有药用资源利用重点实验室
Synthesis of Rupestonic Acid Derivatives with Antiviral Activity
Zhao, JY (Zhao, Jiangyu); Niu, C (Niu, Chao); Li, G (Li, Gen); Aisa, HA (Aisa, Haji Akber)
2017
Source PublicationCHEMISTRY OF NATURAL COMPOUNDS
ISSN0009-3130
Volume53Issue:2Pages:276-283
Abstract

A series of 23 new rupestonic acid derivatives were synthesized. Their activities against influenza viruses A (H3N2, H1N1) and B were studied. Compounds 2d and 2g demonstrated potent activity against influenza virus A (H3N2) with IC50 values of 0.35 and 0.21 mu M, respectively. Compound 5g (n = 10) was the most potent compound of this series against influenza viruses H3N2 and H1N1 with IC50 values of 2.89 and 0.38 mu M. Several of the synthesized compounds were weakly active against influenza virus B and were more toxic than starting rupestonic acid.

DOI10.1007/s10600-017-1970-y
Indexed BySCI
WOS IDWOS:000400195700017
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Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.xjipc.cas.cn/handle/365002/4783
Collection省部共建新疆特有药用资源利用重点实验室
资源化学研究室
Corresponding AuthorAisa, HA (Aisa, Haji Akber)
Affiliation1.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Peoples R China
2.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Basis Xinjiang Indigenous Med Plant, Urumqi 830011, Peoples R China
Recommended Citation
GB/T 7714
Zhao, JY ,Niu, C ,Li, G ,et al. Synthesis of Rupestonic Acid Derivatives with Antiviral Activity[J]. CHEMISTRY OF NATURAL COMPOUNDS,2017,53(2):276-283.
APA Zhao, JY ,Niu, C ,Li, G ,&Aisa, HA .(2017).Synthesis of Rupestonic Acid Derivatives with Antiviral Activity.CHEMISTRY OF NATURAL COMPOUNDS,53(2),276-283.
MLA Zhao, JY ,et al."Synthesis of Rupestonic Acid Derivatives with Antiviral Activity".CHEMISTRY OF NATURAL COMPOUNDS 53.2(2017):276-283.
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