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Controlled release of silyl ether camptothecin from thiol-ene click chemistry-functionalized mesoporous silica nanoparticles
Yan, Y (Yan, Yue); Fu, J (Fu, Jie); Wang, TF (Wang, Tianfu); Lu, XY (Lu, Xiuyang)
2017
发表期刊ACTA BIOMATERIALIA
卷号51期号:3页码:471-478
摘要As efficient drug carriers, stimuli-responsive mesoporous silica nanoparticles are at the forefront of research on drug delivery systems. An acid-responsive system based on silyl ether has been applied to deliver a hybrid prodrug. Thiol-ene click chemistry has been successfully utilized for tethering this pro drug to mesoporous silica nanoparticles. Here, by altering the steric bulk of the substituent on the silicon atom, the release rate of a model drug, camptothecin, was controlled. The synthesized drug delivery system was investigated by analytical methods to confirm the functionalization and conjugation of the mesoporous silica nanoparticles. Herein, trimethyl silyl ether and triethyl silyl ether were selected to regulate the release rate. Under normal plasma conditions (pH 7.4), both types of camptothecin-loaded mesoporous silica nanoparticles (i.e., MSN-Me-CPT and MSN-Et-CPT) did not release the model drug. However, under in vitro acidic conditions (pH 4.0), based on a comparison of the release rates, camptothecin was released from MSN-Me-CPT more rapidly than from MSN-Et-CPT. To determine the biocompatibility of the modified mesoporous silica nanoparticles and the in vivo camptothecin uptake behavior, MIT assays with cancer cells and confocal microscopy observations were conducted, with positive results. These functionalized nanoparticles could be useful in clinical treatments requiring controlled drug release.
关键词Drug Delivery Silyl Ether Click Chemistry Mesoporous Silica Nanoparticles
DOI10.1016/j.actbio.2017.01.062
收录类别SCI
WOS记录号WOS:000398014000037
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.xjipc.cas.cn/handle/365002/4779
专题环境科学与技术研究室
作者单位1.Zhejiang Univ, Coll Chem & Biol Engn, Key Lab Biomass Chem Engn Minist Educ, Hangzhou 310027, Peoples R China
2.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Urumqi 830011, Peoples R China
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Yan, Y ,Fu, J ,Wang, TF ,et al. Controlled release of silyl ether camptothecin from thiol-ene click chemistry-functionalized mesoporous silica nanoparticles[J]. ACTA BIOMATERIALIA,2017,51(3):471-478.
APA Yan, Y ,Fu, J ,Wang, TF ,&Lu, XY .(2017).Controlled release of silyl ether camptothecin from thiol-ene click chemistry-functionalized mesoporous silica nanoparticles.ACTA BIOMATERIALIA,51(3),471-478.
MLA Yan, Y ,et al."Controlled release of silyl ether camptothecin from thiol-ene click chemistry-functionalized mesoporous silica nanoparticles".ACTA BIOMATERIALIA 51.3(2017):471-478.
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