XJIPC OpenIR  > 环境科学与技术研究室
Controlled release of silyl ether camptothecin from thiol-ene click chemistry-functionalized mesoporous silica nanoparticles
Yan, Y (Yan, Yue); Fu, J (Fu, Jie); Wang, TF (Wang, Tianfu); Lu, XY (Lu, Xiuyang)
2017
Source PublicationACTA BIOMATERIALIA
Volume51Issue:3Pages:471-478
AbstractAs efficient drug carriers, stimuli-responsive mesoporous silica nanoparticles are at the forefront of research on drug delivery systems. An acid-responsive system based on silyl ether has been applied to deliver a hybrid prodrug. Thiol-ene click chemistry has been successfully utilized for tethering this pro drug to mesoporous silica nanoparticles. Here, by altering the steric bulk of the substituent on the silicon atom, the release rate of a model drug, camptothecin, was controlled. The synthesized drug delivery system was investigated by analytical methods to confirm the functionalization and conjugation of the mesoporous silica nanoparticles. Herein, trimethyl silyl ether and triethyl silyl ether were selected to regulate the release rate. Under normal plasma conditions (pH 7.4), both types of camptothecin-loaded mesoporous silica nanoparticles (i.e., MSN-Me-CPT and MSN-Et-CPT) did not release the model drug. However, under in vitro acidic conditions (pH 4.0), based on a comparison of the release rates, camptothecin was released from MSN-Me-CPT more rapidly than from MSN-Et-CPT. To determine the biocompatibility of the modified mesoporous silica nanoparticles and the in vivo camptothecin uptake behavior, MIT assays with cancer cells and confocal microscopy observations were conducted, with positive results. These functionalized nanoparticles could be useful in clinical treatments requiring controlled drug release.
KeywordDrug Delivery Silyl Ether Click Chemistry Mesoporous Silica Nanoparticles
DOI10.1016/j.actbio.2017.01.062
Indexed BySCI
WOS IDWOS:000398014000037
Citation statistics
Cited Times:10[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.xjipc.cas.cn/handle/365002/4779
Collection环境科学与技术研究室
资源化学研究室
Affiliation1.Zhejiang Univ, Coll Chem & Biol Engn, Key Lab Biomass Chem Engn Minist Educ, Hangzhou 310027, Peoples R China
2.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Urumqi 830011, Peoples R China
Recommended Citation
GB/T 7714
Yan, Y ,Fu, J ,Wang, TF ,et al. Controlled release of silyl ether camptothecin from thiol-ene click chemistry-functionalized mesoporous silica nanoparticles[J]. ACTA BIOMATERIALIA,2017,51(3):471-478.
APA Yan, Y ,Fu, J ,Wang, TF ,&Lu, XY .(2017).Controlled release of silyl ether camptothecin from thiol-ene click chemistry-functionalized mesoporous silica nanoparticles.ACTA BIOMATERIALIA,51(3),471-478.
MLA Yan, Y ,et al."Controlled release of silyl ether camptothecin from thiol-ene click chemistry-functionalized mesoporous silica nanoparticles".ACTA BIOMATERIALIA 51.3(2017):471-478.
Files in This Item:
File Name/Size DocType Version Access License
Controlled release o(2298KB)期刊论文作者接受稿开放获取CC BY-NC-SAView Application Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Yan, Y (Yan, Yue)]'s Articles
[Fu, J (Fu, Jie)]'s Articles
[Wang, TF (Wang, Tianfu)]'s Articles
Baidu academic
Similar articles in Baidu academic
[Yan, Y (Yan, Yue)]'s Articles
[Fu, J (Fu, Jie)]'s Articles
[Wang, TF (Wang, Tianfu)]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Yan, Y (Yan, Yue)]'s Articles
[Fu, J (Fu, Jie)]'s Articles
[Wang, TF (Wang, Tianfu)]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Controlled release of silyl ether camptothecin from thiol-ene click chemistry-functionalized mesoporous silica nanoparticles.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.