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Phloroglucinol Derivatives with Protein Tyrosine Phosphatase 1B Inhibitory Activities from Eugenia jambolana Seeds
Liu, FF (Liu, Feifei); Yuan, T (Yuan, Tao); Liu, W (Liu, Wei); Ma, H (Ma, Hang); Seeram, NP (Seeram, Navindra P.); Li, YY (Li, Yuanyuan); Xu, L (Xu, Li); Mu, Y (Mu, Yu); Huang, XS (Huang, Xueshi); Li, LY (Li, Liya)
2017
Source PublicationJOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
Volume80Issue:2Pages:544-550
Abstract

Fifteen new phloroglucinol derivatives, jamunones A-O (1-8 and 10-16, respectively), along with one known analogue spiralisone C (9), were isolated from Eugenia jambolana seeds. Their structures were elucidated by detailed nuclear magnetic resonance and mass spectrometry spectroscopic data interpretation. Compounds 1-9, 11, 12, and 14-16 inhibited protein tyrosine phosphatase 1B activity with IC50 values ranging from 0.42 to 3.2 mu M.

DOI10.1021/acs.jnatprod.6b01073
Indexed BySCI
WOS IDWOS:000395046900036
Citation statistics
Cited Times:11[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.xjipc.cas.cn/handle/365002/4745
Collection省部共建新疆特有药用资源利用重点实验室
Affiliation1.Northeastern Univ, Coll Life & Hlth Sci, Inst Microbial Pharmaceut, Shenyang 110819, Peoples R China
2.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Peoples R China
3.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Xinjiang Indigenous Med Plants Reso, Urumqi 830011, Peoples R China
4.Univ Rhode Isl, Coll Pharm, Dept Biomed & Pharmaceut Sci, Bioact Bot Res Lab, Kingston, RI 02881 USA
Recommended Citation
GB/T 7714
Liu, FF ,Yuan, T ,Liu, W ,et al. Phloroglucinol Derivatives with Protein Tyrosine Phosphatase 1B Inhibitory Activities from Eugenia jambolana Seeds[J]. JOURNAL OF NATURAL PRODUCTS,2017,80(2):544-550.
APA Liu, FF .,Yuan, T .,Liu, W .,Ma, H .,Seeram, NP .,...&Li, LY .(2017).Phloroglucinol Derivatives with Protein Tyrosine Phosphatase 1B Inhibitory Activities from Eugenia jambolana Seeds.JOURNAL OF NATURAL PRODUCTS,80(2),544-550.
MLA Liu, FF ,et al."Phloroglucinol Derivatives with Protein Tyrosine Phosphatase 1B Inhibitory Activities from Eugenia jambolana Seeds".JOURNAL OF NATURAL PRODUCTS 80.2(2017):544-550.
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