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Flavans with potential anti-inflammatory activities from Zephyranthes candida
Zhan, GQ (Zhan, Guanqun); Zhou, JF (Zhou, Junfei); Liu, TT (Liu, Tingting); Zheng, GJ (Zheng, Guijuan); Aisa, HA (Aisa, Haji Akber); Yao, GM (Yao, Guangmin)
2016
Source PublicationBIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN0960-894X
Volume26Issue:24Pages:5967-5970
Abstract

Three new flavans, (2R,3R)-7-methoxy-flavan-3-ol (1), (2S)-7,3'-dihydroxy-4'-methoxyflavan 3'-O-beta-D-oglucopyranoside (2), (2S)-7,3'-dihydroxy-4'-methoxyflavan 7-O-beta-D-glucopyranoside (3), and one known flavan (4) were isolated from the whole plants of Zephyranthes candida (Amaryllidacea). The structures of the new flavans 1-3 were determined by extensive spectroscopic analyses including HRESIMS, NMR, and electronic circular dichroism (ECD), and the absolute configuration of 1 was confirmed by single-crystal X-ray diffraction analysis with Cu K alpha irradiation. Flavans 1-3 displayed significant inhibitory effects on the LPS-induced NO production in RAW264.7 mouse macrophages with IC50 values of 17.34, 16.14, and 21.52 mu M, respectively, suggesting their potentials for anti-inflammatory agents. (C) 2016 Elsevier Ltd. All rights reserved.

KeywordZephyranthes Candida Flavans Anti-inflammatory Activities Amaryllidacea
DOI10.1016/j.bmcl.2016.10.081
Indexed BySCI
WOS IDWOS:000389784500027
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.xjipc.cas.cn/handle/365002/4713
Collection省部共建新疆特有药用资源利用重点实验室
资源化学研究室
Affiliation1.Huazhong Univ Sci & Technol, Toni Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Peoples R China
2.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Peoples R China
3.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Basis Xinjiang Indigenous Med Plant, Urumqi 830011, Peoples R China
Recommended Citation
GB/T 7714
Zhan, GQ ,Zhou, JF ,Liu, TT ,et al. Flavans with potential anti-inflammatory activities from Zephyranthes candida[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2016,26(24):5967-5970.
APA Zhan, GQ ,Zhou, JF ,Liu, TT ,Zheng, GJ ,Aisa, HA ,&Yao, GM .(2016).Flavans with potential anti-inflammatory activities from Zephyranthes candida.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,26(24),5967-5970.
MLA Zhan, GQ ,et al."Flavans with potential anti-inflammatory activities from Zephyranthes candida".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 26.24(2016):5967-5970.
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