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Badiranji Buya Keli, a Traditional Uyghur Medicine, Induces Vasodilation in Rat Artery: Signaling Mediated by Nitric Oxide Production in Endothelial Cells
Miernisha, A (Miernisha, A.); Bi, CWC (Bi, Cathy W. C.); Cheng, LKW (Cheng, Lily K. W.); Xing, JG (Xing, J. G.); Liu, J (Liu, J.); Maiwulanjiang, M (Maiwulanjiang, M.); Aisa, HA (Aisa, H. A.); Dong, TNTX (Dong, Tina T. X.); Lin, HQ (Lin, Huangquan); Huang, Y (Huang, Y.); Tsim, KWK (Tsim, Karl W. K.)
2016
Source PublicationPHYTOTHERAPY RESEARCH
ISSN0951-418X
Volume30Issue:1Pages:16-24
Abstract

Badiranji Buya Keli (BBK) is a traditional Uyghur medicine derived from Dracocephalum Moldavica Herba (DMH, the aerial part of Dracocephalum moldavica L.). BBK has been widely used in treating cardiovascular and cerebrovascular diseases. Here, the quality control of BBK was established by using HPLC analysis of rosmarinic acid and tilianin. After chemical standardization, the biological effects of BBK was tested. First, BBK inhibited platelet aggregation of rabbit plasma. Second, BBK induced vasodilation in rat aortic ring, and this effect was partially mediated by nitric oxide (NO) production in endothelial cells. Third, BBK induced NO production in cultured human umbilical vein endothelial cells (HUVECs). In HUVECs, the phosphorylation of endothelial NO synthase (eNOS) was markedly increased after application of BBK. Pre-treatment with the eNOS blocker N-nitro-l-arginine methyl ester hydrochloride could abolish BBK-induced NO production and eNOS phosphorylation. Taken together, these results suggest that BBK could exert beneficial effects in cardiovascular system, which may provide parts of molecular explanation to account for its traditional usage in Uyghur medicine.

KeywordBadiranji Buya Keli Dracocephalum Moldavical Anti-platelet Aggregation Vasodilation Nitric Oxide
DOI10.1002/ptr.5494
Indexed BySCI
WOS IDWOS:000367919300003
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.xjipc.cas.cn/handle/365002/4706
Collection省部共建新疆特有药用资源利用重点实验室
资源化学研究室
Affiliation1.Hong Kong Univ Sci & Technol, Div Life Sci, Hong Kong, Hong Kong, Peoples R China
2.Hong Kong Univ Sci & Technol, Ctr Chinese Med, Hong Kong, Hong Kong, Peoples R China
3.Chinese Univ Hong Kong, Sch Biomed Sci, Li Ka Shing Inst Hlth Sci, Inst Vasc Med, Hong Kong, Hong Kong, Peoples R China
4.Xinjiang Inst Mat Med, Urumqi, Peoples R China
5.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Nat Prod Chem, Urumqi, Peoples R China
Recommended Citation
GB/T 7714
Miernisha, A ,Bi, CWC ,Cheng, LKW ,et al. Badiranji Buya Keli, a Traditional Uyghur Medicine, Induces Vasodilation in Rat Artery: Signaling Mediated by Nitric Oxide Production in Endothelial Cells[J]. PHYTOTHERAPY RESEARCH,2016,30(1):16-24.
APA Miernisha, A .,Bi, CWC .,Cheng, LKW .,Xing, JG .,Liu, J .,...&Tsim, KWK .(2016).Badiranji Buya Keli, a Traditional Uyghur Medicine, Induces Vasodilation in Rat Artery: Signaling Mediated by Nitric Oxide Production in Endothelial Cells.PHYTOTHERAPY RESEARCH,30(1),16-24.
MLA Miernisha, A ,et al."Badiranji Buya Keli, a Traditional Uyghur Medicine, Induces Vasodilation in Rat Artery: Signaling Mediated by Nitric Oxide Production in Endothelial Cells".PHYTOTHERAPY RESEARCH 30.1(2016):16-24.
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