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New isosteroidal alkaloids with tracheal relaxant effect from the bulbs of Fritillaria pallidiflora Schrenk
Li, Y (Li, Yan); Yili, A (Yili, Abulimiti); Li, J (Li, Jun); Muhamat, A (Muhamat, Aziz); Aisa, HA (Aisa, Haji Akber)
2016
Source PublicationBIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN0960-894X
Volume26Issue:8Pages:1983-1987
Abstract

Four new isosteroidal alkaloids, yibeinones A-D (1-4), along with four known ones, imperialine-3 beta-D-glucoside (5), imperialine (6), imperialine beta-N-oxide (7), and dongbeinine (8), were isolated from the bulbs of Fritillaria pallidiflora. Their structures were confirmed on the basis of extensive spectroscopic analysis or comparison with the data in the literatures (known compounds). Compounds 2, 3, 4, and 6 showed an apparent concentration-dependant relaxation of isolated tracheal preparation, amongst 3 and 6 exhibited significant effects with pA(2) values of 6.19 +/- 0.02 and 8.41 +/- 0.10, and EC50 values of 0.65 +/- 0.02 mu mol L-1 and 4.40 +/- 0.90 nmol L-1, respectively.

KeywordFritillaria Pallidiflora Isosteroidal Alkaloid Yibeinones A-d Tracheal Relaxant Effect
DOI10.1016/j.bmcl.2016.03.001
Indexed BySCI
WOS IDWOS:000372509000024
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.xjipc.cas.cn/handle/365002/4668
Collection省部共建新疆特有药用资源利用重点实验室
资源化学研究室
Corresponding AuthorAisa, HA (Aisa, Haji Akber)
Affiliation1.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plants Resources & Chem Arid Zone, Beijing South Rd 40-1, Urumqi 830011, Xinjiang, Peoples R China
2.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Basis Xinjiang Indigenous Med Plant, Beijing South Rd 40-1, Urumqi 830011, Xinjiang, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
Recommended Citation
GB/T 7714
Li, Y ,Yili, A ,Li, J ,et al. New isosteroidal alkaloids with tracheal relaxant effect from the bulbs of Fritillaria pallidiflora Schrenk[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2016,26(8):1983-1987.
APA Li, Y ,Yili, A ,Li, J ,Muhamat, A ,&Aisa, HA .(2016).New isosteroidal alkaloids with tracheal relaxant effect from the bulbs of Fritillaria pallidiflora Schrenk.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,26(8),1983-1987.
MLA Li, Y ,et al."New isosteroidal alkaloids with tracheal relaxant effect from the bulbs of Fritillaria pallidiflora Schrenk".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 26.8(2016):1983-1987.
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