New isosteroidal alkaloids with tracheal relaxant effect from the bulbs of Fritillaria pallidiflora Schrenk
Li, Y (Li, Yan); Yili, A (Yili, Abulimiti); Li, J (Li, Jun); Muhamat, A (Muhamat, Aziz); Aisa, HA (Aisa, Haji Akber)
2016
发表期刊BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷号26期号:8页码:1983-1987
摘要Four new isosteroidal alkaloids, yibeinones A-D (1-4), along with four known ones, imperialine-3 beta-D-glucoside (5), imperialine (6), imperialine beta-N-oxide (7), and dongbeinine (8), were isolated from the bulbs of Fritillaria pallidiflora. Their structures were confirmed on the basis of extensive spectroscopic analysis or comparison with the data in the literatures (known compounds). Compounds 2, 3, 4, and 6 showed an apparent concentration-dependant relaxation of isolated tracheal preparation, amongst 3 and 6 exhibited significant effects with pA(2) values of 6.19 +/- 0.02 and 8.41 +/- 0.10, and EC50 values of 0.65 +/- 0.02 mu mol L-1 and 4.40 +/- 0.90 nmol L-1, respectively.
关键词Fritillaria Pallidiflora Isosteroidal Alkaloid Yibeinones A-d Tracheal Relaxant Effect
DOI10.1016/j.bmcl.2016.03.001
收录类别SCI
WOS记录号WOS:000372509000024
引用统计
文献类型期刊论文
条目标识符http://ir.xjipc.cas.cn/handle/365002/4668
专题省部共建新疆特有药用资源利用重点实验室
作者单位1.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plants Resources & Chem Arid Zone, Beijing South Rd 40-1, Urumqi 830011, Xinjiang, Peoples R China
2.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Basis Xinjiang Indigenous Med Plant, Beijing South Rd 40-1, Urumqi 830011, Xinjiang, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
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Li, Y ,Yili, A ,Li, J ,et al. New isosteroidal alkaloids with tracheal relaxant effect from the bulbs of Fritillaria pallidiflora Schrenk[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2016,26(8):1983-1987.
APA Li, Y ,Yili, A ,Li, J ,Muhamat, A ,&Aisa, HA .(2016).New isosteroidal alkaloids with tracheal relaxant effect from the bulbs of Fritillaria pallidiflora Schrenk.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,26(8),1983-1987.
MLA Li, Y ,et al."New isosteroidal alkaloids with tracheal relaxant effect from the bulbs of Fritillaria pallidiflora Schrenk".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 26.8(2016):1983-1987.
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