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Antioxidants and alpha-glucosidase inhibitors from Ipomoea batatas leaves identified by bioassay-guided approach and structure-activity relationships
Zhang, L (Zhang, Lu); Tu, ZC (Tu, Zong-cai); Yuan, T (Yuan, Tao); Wang, H (Wang, Hui); Xie, X (Xie, Xing); Fu, ZF (Fu, Zhi-feng)
2016
Source PublicationFOOD CHEMISTRY
ISSN0308-8146
Volume208Issue:10Pages:61-67
Abstract

Sweet potato (Ipomoea batatas) leaf (SPL) is an underused commercial vegetable with considerable bio-activities. By means of DPPH center dot scavenging ability and alpha-glucosidase inhibitory oriented isolation, 9 and 7 compounds were isolated and identified, respectively. Among them, trans-N-(p-coumaroyl)tyramine (1), trans-N-feruloyltyramine (2), cis-N-feruloyltyramine (3), 4,5-feruloylcourmaoylquinic acid (8), caffeic acid ethyl ester (10), 7-hydroxy-5-methoxycoumarin (11), 7,3'-dimethylquercetin (13) and indole-3-carboxaldehyde (15), were firstly identified from SPL, and four of them (1, 2, 3 and 10) were firstly identified from genus Ipomoea. Phenethyl cinnamides and 3,4,5-triCQA exhibited the strongest alpha-glucosidase inhibition, while 3,4,5-triCQA and diCQAs were the dominant antioxidants. Structure-activity relationship revealed that higher caffeoylation of quinic acid and lower methoxylation of flavonols resulted in stronger antioxidant activity, and methylation and cis-configuration structure of phenethyl cinnamides weaken the alpha-glucosidase inhibition. Aforementioned results could help to explain the antioxidant activity and anti-diabetic activity of SPL, and provide theoretical basis for its further application.

KeywordIpomoea Batatas Leaves Alpha-glucosidase Antioxidant Activity Identification
DOI10.1016/j.foodchem.2016.03.079
Indexed BySCI
WOS IDWOS:000375856600008
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Document Type期刊论文
Identifierhttp://ir.xjipc.cas.cn/handle/365002/4636
Collection资源化学研究室
Affiliation1.Jiangxi Normal Univ, Minist Educ, Key Lab Funct Small Organ Mol, Nanchang 330022, Jiangxi, Peoples R China
2.Jiangxi Normal Univ, Coll Life Sci, Nanchang 330022, Jiangxi, Peoples R China
3.Nanchang Univ, State Key Lab Food Sci & Technol, Nanchang 330047, Jiangxi, Peoples R China
4.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Urumqi 830011, Peoples R China
Recommended Citation
GB/T 7714
Zhang, L ,Tu, ZC ,Yuan, T ,et al. Antioxidants and alpha-glucosidase inhibitors from Ipomoea batatas leaves identified by bioassay-guided approach and structure-activity relationships[J]. FOOD CHEMISTRY,2016,208(10):61-67.
APA Zhang, L ,Tu, ZC ,Yuan, T ,Wang, H ,Xie, X ,&Fu, ZF .(2016).Antioxidants and alpha-glucosidase inhibitors from Ipomoea batatas leaves identified by bioassay-guided approach and structure-activity relationships.FOOD CHEMISTRY,208(10),61-67.
MLA Zhang, L ,et al."Antioxidants and alpha-glucosidase inhibitors from Ipomoea batatas leaves identified by bioassay-guided approach and structure-activity relationships".FOOD CHEMISTRY 208.10(2016):61-67.
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