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Officimalonic acids A-H, lanostane triterpenes from the fruiting bodies of Fomes officinalis
Han, JX (Han, Jianxin); Li, LY (Li, Liya); Zhong, JL (Zhong, Jialiang); Tohtaton, Z (Tohtaton, Zeynep); Ren, Q (Ren, Qing); Han, L (Han, Li); Huang, XS (Huang, Xueshi); Yuan, T (Yuan, Tao)
2016
Source PublicationPHYTOCHEMISTRY
ISSN0031-9422
Volume130Issue:10Pages:193-200
Abstract

Phytochemical investigation of the methanolic extract of the fruiting bodies of Fomes officinalis led to the isolation of eight 24-methyl-lanostane triterpenes named officimalonic acids A-H, along with one known lanostane triterpene. Their structures were elucidated based on the analysis of spectroscopic data, single-crystal X-ray diffraction, and electronic circular dichroism. Officimalonic acid A represents a previously unknown triterpene type with a 24-methyl-7(8 -> 9)abeo-lanostane skeleton, and all of the compounds possessed a malonate half-ester moiety at C-3. Anti-inflammatory assay revealed that officimalonic acids D, E, G, H, and fomitopsin A showed potent inhibitory effects (IC50 = 5.1-8.9 mu M) on nitric oxide production in lipopolysaccharide-induced RAW264.7 cells. Officimalonic acids E, G, H showed moderate cytotoxicity against H460, HepG2 and BGC-823 human cell lines.

KeywordFomes Officinalis Polyporaceae Lanostane Triterpene Anti-inflammatory Cytotoxicity
DOI10.1016/j.phytochem.2016.05.004
Indexed BySCI
WOS IDWOS:000383302900018
Citation statistics
Document Type期刊论文
Identifierhttp://ir.xjipc.cas.cn/handle/365002/4635
Collection省部共建新疆特有药用资源利用重点实验室
Affiliation1.Chinese Acad Sci, Key Lab Plant Resources & Chem Arid Zone, Xinjiang Tech Inst Phys & Chem, Urumqi 830011, Peoples R China
2.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Xinjiang Indigenous Med Plants Reso, Urumqi 830011, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Northeastern Univ, Coll Life & Hlth Sci, Inst Microbial Pharmaceut, Shenyang 110819, Peoples R China
5.Shanghai Inst Pharmaceut Ind, Shanghai 201203, Peoples R China
Recommended Citation
GB/T 7714
Han, JX ,Li, LY ,Zhong, JL ,et al. Officimalonic acids A-H, lanostane triterpenes from the fruiting bodies of Fomes officinalis[J]. PHYTOCHEMISTRY,2016,130(10):193-200.
APA Han, JX .,Li, LY .,Zhong, JL .,Tohtaton, Z .,Ren, Q .,...&Yuan, T .(2016).Officimalonic acids A-H, lanostane triterpenes from the fruiting bodies of Fomes officinalis.PHYTOCHEMISTRY,130(10),193-200.
MLA Han, JX ,et al."Officimalonic acids A-H, lanostane triterpenes from the fruiting bodies of Fomes officinalis".PHYTOCHEMISTRY 130.10(2016):193-200.
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