Synthesis and biological evaluation of furocoumarin derivatives on melanin synthesis in murine B16 cells for the treatment of vitiligo
Niu, C (Niu, Chao); Pang, GX (Pang, Guang Xian); Li, G (Li, Gen); Dou, J (Dou, Jun); Nie, LF (Nie, Li Fei); Himit, H (Himit, Helimay); Kabas, M (Kabas, Madina); Aisa, HA (Aisa, Haji Akber); Aisa, HA
2016
发表期刊BIOORGANIC & MEDICINAL CHEMISTRY
卷号24期号:22页码:5960-5968
摘要Furocoumarins, isolated from Psoralen corylifolia L., were found to be the most effective drug in the treatment of vitiligo nowadays. Twenty-five furocoumarin derivatives were thus designed and synthesized in order to improve the melanogenesis in B16 cells for the first time. Among them, twenty-three compounds were more potent than the positive control (8-MOP), the commonly used drug for vitiligo in clinic. Noticeably, compounds 6m (350.5%) and 6p (313.1%) based on the scaffold of 6k (2H-benzofuro[2,3-h] chromen-2-one) were nearly 3-fold stronger than 8-MOP (114.50%). The in vitro melanin synthesis evaluation of these structurally diverse analogues had also led to an outline of structure-activity relationship.
关键词Furocoumarin Synthesis Melanin Vitiligo Sar
DOI10.1016/j.bmc.2016.09.056
收录类别SCI
WOS记录号WOS:000387200000029
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文献类型期刊论文
条目标识符http://ir.xjipc.cas.cn/handle/365002/4626
专题省部共建新疆特有药用资源利用重点实验室
通讯作者Aisa, HA
作者单位1.Chinese Acad Sci, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Peoples R China
2.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Basis Xinjiang Indigenous Med Plant, Urumqi 830011, Peoples R China
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Niu, C ,Pang, GX ,Li, G ,et al. Synthesis and biological evaluation of furocoumarin derivatives on melanin synthesis in murine B16 cells for the treatment of vitiligo[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2016,24(22):5960-5968.
APA Niu, C .,Pang, GX .,Li, G .,Dou, J .,Nie, LF .,...&Aisa, HA.(2016).Synthesis and biological evaluation of furocoumarin derivatives on melanin synthesis in murine B16 cells for the treatment of vitiligo.BIOORGANIC & MEDICINAL CHEMISTRY,24(22),5960-5968.
MLA Niu, C ,et al."Synthesis and biological evaluation of furocoumarin derivatives on melanin synthesis in murine B16 cells for the treatment of vitiligo".BIOORGANIC & MEDICINAL CHEMISTRY 24.22(2016):5960-5968.
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