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Preparation of phenylboronate affinity rigid monolith with macromolecular porogen
Li, Xiang-Jie; Jia, Man; Zhao, Yong-Xin; Liu, Zhao-Sheng; Akber Aisa, Haji
2016
Source PublicationJOURNAL OF CHROMATOGRAPHY A
ISSN0021-9673
Volume1438Issue:3Pages:171-178
Abstract

Boronate-affinity monolithic column was first prepared via polystyrene (PS) as porogen in this work. The monolithic polymer was synthetized using 4-vinylphenylboronic acid (4-VPBA) as functional monomer, ethylene glycol dimethacrylate (EDMA) as crosslinker monomer, and a mixture of PS solution in tetrahydrofuran, the linear macromolecular porogen, and toluene as porogen. Isoquercitrin (ISO) and hyperoside (HYP), isomer diol flavonoid glycosides, can be baseline separated on the poly(VPBA-co-EDMA) monolith. The effect of polymerization variables on the selectivity factor, e.g., the ratio of monomer to crosslinker (M/C), the amount of PS and the molecular weight of macromolecular porogen was investigated. The surface properties of the monolithic polymer were characterized by scanning electron microscopy and nitrogen adsorption. The best polymerization condition was the M/C ratio of 7:3, and the PS concentration of 40mg/ml. The poly(VPBA-co-EDMA) polymer was also applied to extract cis-diol flavonoid glycosides from the crude extraction of cotton flower. After treated by poly(VPBA-co-EDMA) for solid phase extraction, high purity ISO and HYP (>99.96%) can be obtained with recovery of 83.7% and 78.6%, respectively.

KeywordFlavonol Glycosides Hplc Macromolecular Porogen Monolithic Column Phenylboronate Affinity Monolith Solid Phase Extraction
DOI10.1016/j.chroma.2016.02.031
Indexed BySCI
WOS IDWOS:000371941500018
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.xjipc.cas.cn/handle/365002/4353
Collection资源化学研究室
Corresponding AuthorAkber Aisa, Haji
Affiliation1.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Urumqi 830011, Xinjiang, Peoples R China
2.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Basis Xinjiang Indigenous Med Plant, Urumqi 830011, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
Recommended Citation
GB/T 7714
Li, Xiang-Jie,Jia, Man,Zhao, Yong-Xin,et al. Preparation of phenylboronate affinity rigid monolith with macromolecular porogen[J]. JOURNAL OF CHROMATOGRAPHY A,2016,1438(3):171-178.
APA Li, Xiang-Jie,Jia, Man,Zhao, Yong-Xin,Liu, Zhao-Sheng,&Akber Aisa, Haji.(2016).Preparation of phenylboronate affinity rigid monolith with macromolecular porogen.JOURNAL OF CHROMATOGRAPHY A,1438(3),171-178.
MLA Li, Xiang-Jie,et al."Preparation of phenylboronate affinity rigid monolith with macromolecular porogen".JOURNAL OF CHROMATOGRAPHY A 1438.3(2016):171-178.
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