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Diterpenoid constituents of Euphorbia macrorrhiza
Gao, J (Gao, Jie); Chen, QB (Chen, Qi-Bin); Liu, YQ (Liu, Yong-Qiang); Xin, XL (Xin, Xue-Lei); Yili, A (Yili, Ablimiti); Aisa, HA (Aisa, Haji Akber)
Source PublicationPHYTOCHEMISTRY

Ten diterpenoids, named macrorilone A-B, macroripremyrsinone A, macrorilathyrone A-B, macrorieuphorone A-B and macroricasbalone A-C, together with ten known diterpenoids, jatrophalone, sikkimenoids A-D, jatrophodione A, latilagascenes F, jolkinol B, 15 beta-O-benzoyl-5 alpha-hydroxyisolathyrol and jatrophalactone were isolated from the whole plant of Euphorbia macrorrhiza C.A. Mey. These diterpenoids belong to six skeleton-types, including jatropholane, premyrsinane, lathyrane, euphoractin, casbene and rhamnofolane diterpenoids. Their structures were elucidated by extensive analysis of 1D, 2D NMR and HRESIMS spectroscopic data. The absolute configurations of macrorilone B, macroripremyrsinone A and macrorilathyrone A were established by comparing their experimental and calculated electronic circular dichroism (ECD) spectra. Several of the isolated compounds exhibited weak cytotoxicity against the KB and KBv200 cell lines with IC50 values ranging from 21.19 to 47.87 mu M. Some also showed multidrug resistance (MDR) reversal activity, among which macrorilathyrone B exhibited a remarkable inhibitory effect on P-gp-mediated drug exclusion.

KeywordEuphorbia Macrorrhiza Ca Mey Euphorbiaceae Diterpenoids Cytotoxicity Multidrug Resistance Reversal Activity
Indexed BySCI
WOS IDWOS:000369460200027
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Cited Times:11[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorAisa, HA (Aisa, Haji Akber)
Affiliation1.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Peoples R China
2.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Basis Xinjiang Indigenous Med Plant, Urumqi 830011, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
Recommended Citation
GB/T 7714
Gao, J ,Chen, QB ,Liu, YQ ,et al. Diterpenoid constituents of Euphorbia macrorrhiza[J]. PHYTOCHEMISTRY,2016,122(2):246-253.
APA Gao, J ,Chen, QB ,Liu, YQ ,Xin, XL ,Yili, A ,&Aisa, HA .(2016).Diterpenoid constituents of Euphorbia macrorrhiza.PHYTOCHEMISTRY,122(2),246-253.
MLA Gao, J ,et al."Diterpenoid constituents of Euphorbia macrorrhiza".PHYTOCHEMISTRY 122.2(2016):246-253.
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