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题名: Characterization and Identification of the Chemical Compositions in a Traditional Uighur Medicine Prescription Yizhihao Granule by LC-ESI-QTOF-MS
作者: Gu, DY (Gu, Dongyu); Yang, Y (Yang, Yi); Hang, B (Hang, Ba); Lv, QY (Lv, Qiaoying); Aisa, HA (Aisa, Haji Akber
通讯作者: Aisa, HA
关键词: traditional Uighur medicinal prescription ; Yizhihao granule ; fragmentation pathways ; chemical compositions ; LC-QTOF-MS/MS ; characterization and identification
刊名: JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES
发表日期: 2015
DOI: 10.1080/10826076.2014.903848
卷: 38, 期:2, 页:229-242
收录类别: SCI
资助者: National Basic Research Program of China;West Light Foundation of The Chinese Academy of Sciences;National Natural Science Foundation of China;China National Funds for Distinguished Young Scientists
摘要: An efficient method was developed and established for the rapid analysis of a traditional Uighur medicinal prescription, Yizhihao granule, by liquid chromatography-Quadrupole time-of-flight tandem mass spectrometry. HPLC was performed with a Poroshell 120-EC18 column with 2.7 mu m particle size using A gradient elution system. A quadrupole time-of-flight analyzer was used for the determination of accurate mass of the protonated or deprotonated molecules and fragment ions. Sixty-six constituents including amino acids, organic acids (aliphatic acids, benzoic acid derivatives, and chlorogenic acids), alkaloids (indole and quinazolinone type), flavonoids (C,O-glycoside, C-glycosides, O-glycosides, and aglycone), sesquiterpenoids (rupestonic acid derivatives), and other compounds were identified or tentatively characterized in Yizhihao granule as a presented application of prescription according to the accurate mass, MS/MS data, and relevant literature. Additionally, the fragmentation pathways of two rupestonic acid derivatives were proposed. The relationship between structure features and fragmentation patterns were investigated thoroughly and applied in the on-line analysis to deduce the composition of traditional Uighur herbal prescription. The present method and results should be beneficial in the development of traditional Uighur herbal prescription.
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内容类型: 期刊论文
URI标识: http://ir.xjipc.cas.cn/handle/365002/4208
Appears in Collections:新疆维吾尔自治区植物资源化学重点实验室 _期刊论文

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作者单位: Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Xinjiang Indigenous Med Plants Resource U, Urumqi 830011, Peoples R China;Dalian Ocean Univ, Sch Marine Sci & Environm Engn, Dalian, Peoples R China

Recommended Citation:
Gu, DY ,Yang, Y ,Hang, B ,et al. Characterization and Identification of the Chemical Compositions in a Traditional Uighur Medicine Prescription Yizhihao Granule by LC-ESI-QTOF-MS[J]. JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES,2015,38(2):229-242.
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文件名: Characterization and Identification of the Chemical Compositions in a Traditional Uighur Medicine Prescription Yizhihao Granule by LC-ESI-QTOF-MS .pdf
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