中国科学院新疆理化技术研究所机构知识库
Advanced  
XJIPC OpenIR  > 省部共建新疆特有药用资源利用重点实验室  > 期刊论文
题名: The Volatile Oil of Nardostachyos Radix et Rhizoma Induces Endothelial Nitric Oxide Synthase Activity in HUVEC Cells
作者: Maiwulanjiang, M (Maiwulanjiang, Maitinuer); Bi, CWC (Bi, Cathy W. C.); Lee, PSC (Lee, Pinky S. C.); Xin, G (Xin, Guizhong); Miernisha, A (Miernisha, Abudureyimu); Lau, KM (Lau, Kei M.); Xiong, A (Xiong, Aizhen); Li, N (Li, Ning); Dong, TTX (Dong, Tina T. X.); Aisa, HA (Aisa, Haji A.)
关键词: PHOSPHORYLATION ; INJURY ; AKT ; IDENTIFICATION ; ACTIVATION ; JATAMANSI ; PATHWAY ; SYSTEM ; OXYGEN ; ENOS
刊名: PLOS ONE
发表日期: 2015
DOI: 10.1371/journal.pone.0116761
卷: 10, 期:2
收录类别: SCI
资助者: Hong Kong Research Grants Council Theme-based Research Scheme;GRF ;Hong Kong Jockey Club Charities Trust;Foundation of The Awareness of Nature
摘要: Nardostahyos Radix et Rhizoma (NRR; the root and rhizome of Nardostachys jatamansi DC.) is a widely used medicinal herb. Historically, NRR is being used for the treatment of cardiovascular and neurological diseases. To search for active ingredients of NRR, we investigated the vascular benefit of NRR volatile oil in (i) the vasodilation in rat aorta ring, and (ii) the release of nitric oxide (NO) and the phosphorylation of endothelial NO synthase (eNOS) in cultured human umbilical vein endothelial cells (HUVECs). By measuring the fluorescence signal in cultures, application of NRR volatile oil resulted in a rapid activation of NO release as well as the phosphorylation of eNOS: both inductions were markedly reduced by L-NAME. In parallel, the phosphorylation level of Akt kinase was markedly increased by the oil treatment, which was partially attenuated by PI3K/Akt inhibitor LY294002. This inhibitor also blocked the NRR-induced NO production and eNOS phosphorylation. In HUVECs, application of NRR volatile oil elevated the intracellular Ca2+ level, and BAPTA-AM, a Ca2+ chelator, reduced the Ca2+ surge: the blockage were also applied to NRR-induced eNOS phosphorylation and NO production. These findings suggested the volatile oil of NRR was the major ingredient in triggering the vascular dilatation, and which was mediated via the NO production.
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.xjipc.cas.cn/handle/365002/4205
Appears in Collections:新疆维吾尔自治区植物资源化学重点实验室 _期刊论文

Files in This Item:
File Name/ File Size Content Type Version Access License
The Volatile Oil of Nardostachyos Radix et Rhizoma Induces Endothelial Nitric Oxide Synthase Activity in HUVEC Cells .pdf(1940KB)期刊论文作者接受稿开放获取View 联系获取全文

作者单位: Hong Kong Univ Sci & Technol, Div Life Sci, Hong Kong, Peoples R China;Hong Kong Univ Sci & Technol, Ctr Chinese Med, Hong Kong, Peoples R China;Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Xinjiang Key Lab Plant Resources & Nat Prod Chem, Urumqi, Peoples R China

Recommended Citation:
Maiwulanjiang, M ,Bi, CWC ,Lee, PSC ,et al. The Volatile Oil of Nardostachyos Radix et Rhizoma Induces Endothelial Nitric Oxide Synthase Activity in HUVEC Cells[J]. PLOS ONE,2015,10(2).
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Maiwulanjiang, M (Maiwulanjiang, Maitinuer)]'s Articles
[Bi, CWC (Bi, Cathy W. C.)]'s Articles
[Lee, PSC (Lee, Pinky S. C.)]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Maiwulanjiang, M (Maiwulanjiang, Maitinuer)]‘s Articles
[Bi, CWC (Bi, Cathy W. C.)]‘s Articles
[Lee, PSC (Lee, Pinky S. C.)]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: The Volatile Oil of Nardostachyos Radix et Rhizoma Induces Endothelial Nitric Oxide Synthase Activity in HUVEC Cells .pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace