An efficient, enantioselective total synthesis of (-)-lasubine I (1) has been achieved in an overall 8.8% yield from readily available starting materials. The important features of this approach include the creation of stereogenic centers through two sequential highly stereoselective Roush allylborations and the use of S(N)2 cyclization and ring-closing metathesis reactions for the construction of the quinolizidine skeleton.
Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Urumqi 830011, Peoples R China;China Pharmaceut Univ, Dept Med Chem, Nanjing 210009, Peoples R China;E China Univ Sci & Technol, Sch Pharm, Dept Med Chem, Shanghai 200237, Peoples R China;Univ New Mexico, Dept Chem, Albuquerque, NM 87131 USA;Chinese Acad Sci, Grad Sch, Shanghai Inst Mat Med, Shanghai Inst Biol Sci, Shanghai 201203, Peoples R China
Recommended Citation:
Liu, Shengyang,Fan, Yuping,Peng, Xinxiang,et al. A concise and enantioselective approach to the total synthesis of (-)-lasubine I[J]. TETRAHEDRON LETTERS,2006,47(44):7681-7684.
