XJIPC OpenIR  > 资源化学研究室
Evaluation of poly(styrene-alt-maleic anhydride)-ethanol as enteric coating material
Lai, Xiaolin; Sun, Chengdong; Tian, Hua; Zhao, Wenjun; Gao, Lin
2008
发表期刊INTERNATIONAL JOURNAL OF PHARMACEUTICS
ISSN0378-5173
卷号352期号:1-2页码:66-73
摘要

This study aims at evaluating the potential of SMA-ethanol as enteric coating polymer for erythromycin tablets. SMA-ethanol was synthesized and characterized for physicochemical properties, molecular weight and thermal analysis. Free films were prepared by adding different kinds and amounts of plasticizers, the film surface topography was determined by a SEM, the tensile strength, water vapor transmission rate and moisture absorption were also tested to choose the most promising film. DBP was proved to be the most suitable plasticizer with a best using amount of 20%, such polymer films had low vapor transmission rate and low moisture absorption which were very important to an enteric coating material. The polymer was further characterized for film coating by evaluating the release of erythromycin tablets in vitro, tablets coated with SMA-ethanol can satisfy the drug release requests of USP when the film weight gains were between 4 and 6%; tablets coated with both a subcoat and the polymer showed excellent gastro-resistance, less than 0.2% drug release occurred even with weight gains as less as 2% after 2 h exposure to acid (pH 1), while over 90% drug release occurred in pH 6.8 sodium phosphate buffer within 45 min, regardless of weight gains of coating material, moreover, we confirmed that the application of a subcoat could decrease the amount of required coating polymer. In conclusion, the potential use of SMA-ethanol as enteric coating material was demonstrated.

关键词Sma-ethanol Enteric Coating Erythromycin Tablets
DOI10.1016/j.ijpharm.2007.10.011
收录类别SCI
WOS记录号WOS:000254603400009
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.xjipc.cas.cn/handle/365002/4106
专题资源化学研究室
作者单位Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Urumqi 830011, Peoples R China;Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714
Lai, Xiaolin,Sun, Chengdong,Tian, Hua,et al. Evaluation of poly(styrene-alt-maleic anhydride)-ethanol as enteric coating material[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2008,352(1-2):66-73.
APA Lai, Xiaolin,Sun, Chengdong,Tian, Hua,Zhao, Wenjun,&Gao, Lin.(2008).Evaluation of poly(styrene-alt-maleic anhydride)-ethanol as enteric coating material.INTERNATIONAL JOURNAL OF PHARMACEUTICS,352(1-2),66-73.
MLA Lai, Xiaolin,et al."Evaluation of poly(styrene-alt-maleic anhydride)-ethanol as enteric coating material".INTERNATIONAL JOURNAL OF PHARMACEUTICS 352.1-2(2008):66-73.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Evaluation of poly(s(677KB)期刊论文作者接受稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Lai, Xiaolin]的文章
[Sun, Chengdong]的文章
[Tian, Hua]的文章
百度学术
百度学术中相似的文章
[Lai, Xiaolin]的文章
[Sun, Chengdong]的文章
[Tian, Hua]的文章
必应学术
必应学术中相似的文章
[Lai, Xiaolin]的文章
[Sun, Chengdong]的文章
[Tian, Hua]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Evaluation of poly(styrene-alt-maleic anhydride)-ethanol as enteric coating material.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。