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Evaluation of poly(styrene-alt-maleic anhydride)-ethanol as enteric coating material
Lai, Xiaolin; Sun, Chengdong; Tian, Hua; Zhao, Wenjun; Gao, Lin
2008
Source PublicationINTERNATIONAL JOURNAL OF PHARMACEUTICS
ISSN0378-5173
Volume352Issue:1-2Pages:66-73
Abstract

This study aims at evaluating the potential of SMA-ethanol as enteric coating polymer for erythromycin tablets. SMA-ethanol was synthesized and characterized for physicochemical properties, molecular weight and thermal analysis. Free films were prepared by adding different kinds and amounts of plasticizers, the film surface topography was determined by a SEM, the tensile strength, water vapor transmission rate and moisture absorption were also tested to choose the most promising film. DBP was proved to be the most suitable plasticizer with a best using amount of 20%, such polymer films had low vapor transmission rate and low moisture absorption which were very important to an enteric coating material. The polymer was further characterized for film coating by evaluating the release of erythromycin tablets in vitro, tablets coated with SMA-ethanol can satisfy the drug release requests of USP when the film weight gains were between 4 and 6%; tablets coated with both a subcoat and the polymer showed excellent gastro-resistance, less than 0.2% drug release occurred even with weight gains as less as 2% after 2 h exposure to acid (pH 1), while over 90% drug release occurred in pH 6.8 sodium phosphate buffer within 45 min, regardless of weight gains of coating material, moreover, we confirmed that the application of a subcoat could decrease the amount of required coating polymer. In conclusion, the potential use of SMA-ethanol as enteric coating material was demonstrated.

KeywordSma-ethanol Enteric Coating Erythromycin Tablets
DOI10.1016/j.ijpharm.2007.10.011
Indexed BySCI
WOS IDWOS:000254603400009
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.xjipc.cas.cn/handle/365002/4106
Collection资源化学研究室
AffiliationChinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Urumqi 830011, Peoples R China;Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Lai, Xiaolin,Sun, Chengdong,Tian, Hua,et al. Evaluation of poly(styrene-alt-maleic anhydride)-ethanol as enteric coating material[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2008,352(1-2):66-73.
APA Lai, Xiaolin,Sun, Chengdong,Tian, Hua,Zhao, Wenjun,&Gao, Lin.(2008).Evaluation of poly(styrene-alt-maleic anhydride)-ethanol as enteric coating material.INTERNATIONAL JOURNAL OF PHARMACEUTICS,352(1-2),66-73.
MLA Lai, Xiaolin,et al."Evaluation of poly(styrene-alt-maleic anhydride)-ethanol as enteric coating material".INTERNATIONAL JOURNAL OF PHARMACEUTICS 352.1-2(2008):66-73.
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