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题名: Evaluation of poly(styrene-alt-maleic anhydride)-ethanol as enteric coating material
作者: Lai, Xiaolin; Sun, Chengdong; Tian, Hua; Zhao, Wenjun; Gao, Lin
关键词: SMA-ethanol ; enteric coating ; erythromycin tablets
刊名: INTERNATIONAL JOURNAL OF PHARMACEUTICS
发表日期: 2008
DOI: 10.1016/j.ijpharm.2007.10.011
卷: 352, 期:1-2, 页:66-73
收录类别: SCI
摘要: This study aims at evaluating the potential of SMA-ethanol as enteric coating polymer for erythromycin tablets. SMA-ethanol was synthesized and characterized for physicochemical properties, molecular weight and thermal analysis. Free films were prepared by adding different kinds and amounts of plasticizers, the film surface topography was determined by a SEM, the tensile strength, water vapor transmission rate and moisture absorption were also tested to choose the most promising film. DBP was proved to be the most suitable plasticizer with a best using amount of 20%, such polymer films had low vapor transmission rate and low moisture absorption which were very important to an enteric coating material. The polymer was further characterized for film coating by evaluating the release of erythromycin tablets in vitro, tablets coated with SMA-ethanol can satisfy the drug release requests of USP when the film weight gains were between 4 and 6%; tablets coated with both a subcoat and the polymer showed excellent gastro-resistance, less than 0.2% drug release occurred even with weight gains as less as 2% after 2 h exposure to acid (pH 1), while over 90% drug release occurred in pH 6.8 sodium phosphate buffer within 45 min, regardless of weight gains of coating material, moreover, we confirmed that the application of a subcoat could decrease the amount of required coating polymer. In conclusion, the potential use of SMA-ethanol as enteric coating material was demonstrated.
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内容类型: 期刊论文
URI标识: http://ir.xjipc.cas.cn/handle/365002/4106
Appears in Collections:资源化学研究室_期刊论文

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作者单位: Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Urumqi 830011, Peoples R China;Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China

Recommended Citation:
Lai, Xiaolin,Sun, Chengdong,Tian, Hua,et al. Evaluation of poly(styrene-alt-maleic anhydride)-ethanol as enteric coating material[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2008,352(1-2):66-73.
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