Song Bu Li Decoction, a Traditional Uyghur Medicine, Protects Cell Death by Regulation of Oxidative Stress and Differentiation in Cultured PC12 Cells
Maiwulanjiang, Maitinuer; Zhu, Kevin Y.; Chen, Jianping; Miernisha, Abudureyimu; Xu, Sherry L.; Du, Crystal Y. Q.; Lau, Kitty K. M.; Choi, Roy C. Y.; Dong, Tina T. X.; Aisa, Haji A.; Tsim, Karl W. K.
2013
发表期刊EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
ISSN1741-427X
卷号2013期号:2
摘要

Song Bu Li decoction (SBL) is a traditional Uyghur medicinal herbal preparation, containing Nardostachyos Radix et Rhizoma. Recently, SBL is being used to treat neurological disorders (insomnia and neurasthenia) and heart disorders (arrhythmia and palpitation). Although this herbal extract has been used for many years, there is no scientific basis about its effectiveness. Here, we aimed to evaluate the protective and differentiating activities of SBL in cultured PC12 cells. The pretreatment of SBL protected the cell against tBHP-induced cell death in a dose-dependent manner. In parallel, SBL suppressed intracellular reactive oxygen species (ROS) formation. The transcriptional activity of antioxidant response element (ARE), as well as the key antioxidative stress proteins, was induced in dose-dependent manner by SBL in the cultures. In cultured PC12 cells, the expression of neurofilament, a protein marker for neuronal differentiation, was markedly induced by applied herbal extract. Moreover, the nerve growth factor- (NGF-) induced neurite outgrowth in cultured PC12 cells was significantly potentiated by the cotreatment of SBL. In accord, the expression of neurofilament was increased in the treatment of SBL. These results therefore suggested a possible role of SBL by its effect on neuron differentiation and protection against oxidative stress.

DOI10.1155/2013/687958
收录类别SCI
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文献类型期刊论文
条目标识符http://ir.xjipc.cas.cn/handle/365002/3911
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作者单位Hong Kong Univ Sci & Technol, Div Life Sci, Hong Kong, Hong Kong, Peoples R China;Hong Kong Univ Sci & Technol, Ctr Chinese Med, Hong Kong, Hong Kong, Peoples R China;Chinese Acad Sci, Xinjiang Key Lab Plant Resources & Nat Prod Chem, Xinjiang Tech Inst Phys & Chem, Urumqi 830011, Peoples R China
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Maiwulanjiang, Maitinuer,Zhu, Kevin Y.,Chen, Jianping,et al. Song Bu Li Decoction, a Traditional Uyghur Medicine, Protects Cell Death by Regulation of Oxidative Stress and Differentiation in Cultured PC12 Cells[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2013,2013(2).
APA Maiwulanjiang, Maitinuer.,Zhu, Kevin Y..,Chen, Jianping.,Miernisha, Abudureyimu.,Xu, Sherry L..,...&Tsim, Karl W. K..(2013).Song Bu Li Decoction, a Traditional Uyghur Medicine, Protects Cell Death by Regulation of Oxidative Stress and Differentiation in Cultured PC12 Cells.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2013(2).
MLA Maiwulanjiang, Maitinuer,et al."Song Bu Li Decoction, a Traditional Uyghur Medicine, Protects Cell Death by Regulation of Oxidative Stress and Differentiation in Cultured PC12 Cells".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 2013.2(2013).
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