XJIPC OpenIR  > 省部共建新疆特有药用资源利用重点实验室
Jatrophane diterpenoid esters from Euphorbia sororia serving as multidrug resistance reversal agents
Lu, Dongli; Liu, Yongqiang; Aisa, Haji Akber
2014
Source PublicationFITOTERAPIA
ISSN0367-326X
Volume92Issue:1Pages:244-251
Abstract

Six (1-6) new jatrophane diterpenoid esters together with four known compounds (7-10) were isolated from the acetone extract of fructus Euphorbia sororia. Their structures were elucidated by the spectral technology, including the 2D NMR experiments (HMQC, HMBC and NOESY). The absolute configuration of compound 1 and compound 7 were first confirmed by X-ray crystallographic analysis. Compounds 1-7 were assayed for their antiproliferative activity in human cancer cell lines: human mammary adenocarcinoma (MCF-7) and human lung adenocarcinoma (A549). All the compounds were inactive for the cell lines. The multidrug-resistance reversal activity was also tested on KBv200 cells and compound 2 displayed strong multidrug resistance reversal activity, outperforming verapamil at 10 mu M.

KeywordEuphorbia Sororia Uyghur Medicine Jatrophane Diterpenoid Esters Multidrug Resistance Reversal Activity
DOI10.1016/j.fitote.2013.11.008
Indexed BySCI
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Cited Times:10[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.xjipc.cas.cn/handle/365002/3838
Collection省部共建新疆特有药用资源利用重点实验室
Corresponding AuthorAisa, Haji Akber
Affiliation1.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Peoples R China
2.State Key Lab Basis Xinjiang Indigenous Med Plant, Urumqi 830011, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
Recommended Citation
GB/T 7714
Lu, Dongli,Liu, Yongqiang,Aisa, Haji Akber. Jatrophane diterpenoid esters from Euphorbia sororia serving as multidrug resistance reversal agents[J]. FITOTERAPIA,2014,92(1):244-251.
APA Lu, Dongli,Liu, Yongqiang,&Aisa, Haji Akber.(2014).Jatrophane diterpenoid esters from Euphorbia sororia serving as multidrug resistance reversal agents.FITOTERAPIA,92(1),244-251.
MLA Lu, Dongli,et al."Jatrophane diterpenoid esters from Euphorbia sororia serving as multidrug resistance reversal agents".FITOTERAPIA 92.1(2014):244-251.
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