Jatrophane diterpenoid esters from Euphorbia sororia serving as multidrug resistance reversal agents
Lu, Dongli; Liu, Yongqiang; Aisa, Haji Akber; Aisa, HA
2014
发表期刊FITOTERAPIA
ISSN0367-326X
卷号92期号:1页码:244-251
摘要Six (1-6) new jatrophane diterpenoid esters together with four known compounds (7-10) were isolated from the acetone extract of fructus Euphorbia sororia. Their structures were elucidated by the spectral technology, including the 2D NMR experiments (HMQC, HMBC and NOESY). The absolute configuration of compound 1 and compound 7 were first confirmed by X-ray crystallographic analysis. Compounds 1-7 were assayed for their antiproliferative activity in human cancer cell lines: human mammary adenocarcinoma (MCF-7) and human lung adenocarcinoma (A549). All the compounds were inactive for the cell lines. The multidrug-resistance reversal activity was also tested on KBv200 cells and compound 2 displayed strong multidrug resistance reversal activity, outperforming verapamil at 10 mu M.
关键词Euphorbia Sororia Uyghur Medicine Jatrophane Diterpenoid Esters Multidrug Resistance Reversal Activity
资助者International Cooperation and Exchange of the National Natural Science Foundation of China;National Science Foundation for Distinguished Young Scholars of China ; International Cooperation and Exchange of the National Natural Science Foundation of China;National Science Foundation for Distinguished Young Scholars of China ; International Cooperation and Exchange of the National Natural Science Foundation of China;National Science Foundation for Distinguished Young Scholars of China ; International Cooperation and Exchange of the National Natural Science Foundation of China;National Science Foundation for Distinguished Young Scholars of China
DOI10.1016/j.fitote.2013.11.008
收录类别SCI
资助者International Cooperation and Exchange of the National Natural Science Foundation of China;National Science Foundation for Distinguished Young Scholars of China ; International Cooperation and Exchange of the National Natural Science Foundation of China;National Science Foundation for Distinguished Young Scholars of China ; International Cooperation and Exchange of the National Natural Science Foundation of China;National Science Foundation for Distinguished Young Scholars of China ; International Cooperation and Exchange of the National Natural Science Foundation of China;National Science Foundation for Distinguished Young Scholars of China
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被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.xjipc.cas.cn/handle/365002/3838
专题省部共建新疆特有药用资源利用重点实验室
通讯作者Aisa, HA
作者单位Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Peoples R China;State Key Lab Basis Xinjiang Indigenous Med Plant, Urumqi 830011, Peoples R China;Univ Chinese Acad Sci, Beijing 100039, Peoples R China
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Lu, Dongli,Liu, Yongqiang,Aisa, Haji Akber,et al. Jatrophane diterpenoid esters from Euphorbia sororia serving as multidrug resistance reversal agents[J]. FITOTERAPIA,2014,92(1):244-251.
APA Lu, Dongli,Liu, Yongqiang,Aisa, Haji Akber,&Aisa, HA.(2014).Jatrophane diterpenoid esters from Euphorbia sororia serving as multidrug resistance reversal agents.FITOTERAPIA,92(1),244-251.
MLA Lu, Dongli,et al."Jatrophane diterpenoid esters from Euphorbia sororia serving as multidrug resistance reversal agents".FITOTERAPIA 92.1(2014):244-251.
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