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题名: Jatrophane diterpenoid esters from Euphorbia sororia serving as multidrug resistance reversal agents
作者: Lu, Dongli; Liu, Yongqiang; Aisa, Haji Akber
通讯作者: Aisa, HA
关键词: Euphorbia sororia ; Uyghur medicine ; Jatrophane diterpenoid esters ; Multidrug resistance reversal activity
刊名: FITOTERAPIA
发表日期: 2014
DOI: 10.1016/j.fitote.2013.11.008
卷: 92, 期:1, 页:244-251
收录类别: SCI
资助者: International Cooperation and Exchange of the National Natural Science Foundation of China;National Science Foundation for Distinguished Young Scholars of China
摘要: Six (1-6) new jatrophane diterpenoid esters together with four known compounds (7-10) were isolated from the acetone extract of fructus Euphorbia sororia. Their structures were elucidated by the spectral technology, including the 2D NMR experiments (HMQC, HMBC and NOESY). The absolute configuration of compound 1 and compound 7 were first confirmed by X-ray crystallographic analysis. Compounds 1-7 were assayed for their antiproliferative activity in human cancer cell lines: human mammary adenocarcinoma (MCF-7) and human lung adenocarcinoma (A549). All the compounds were inactive for the cell lines. The multidrug-resistance reversal activity was also tested on KBv200 cells and compound 2 displayed strong multidrug resistance reversal activity, outperforming verapamil at 10 mu M.
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内容类型: 期刊论文
URI标识: http://ir.xjipc.cas.cn/handle/365002/3838
Appears in Collections:新疆维吾尔自治区植物资源化学重点实验室 _期刊论文

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作者单位: Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Peoples R China;State Key Lab Basis Xinjiang Indigenous Med Plant, Urumqi 830011, Peoples R China;Univ Chinese Acad Sci, Beijing 100039, Peoples R China

Recommended Citation:
Lu, Dongli,Liu, Yongqiang,Aisa, Haji Akber. Jatrophane diterpenoid esters from Euphorbia sororia serving as multidrug resistance reversal agents[J]. FITOTERAPIA,2014,92(1):244-251.
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