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题名: Efficient Synthesis of alpha-Quaternary alpha-Hydroxy-beta-amino Esters via Silyl Glyoxylate-Mediated Three-Component Reactions
作者: Jiang, Jiu-Long; Yao, Ming; Lu, Chong-Dao
通讯作者: Lu, CD
刊名: ORGANIC LETTERS
发表日期: 2014
DOI: 10.1021/ol403388w
卷: 16, 期:1, 页:318-321
收录类别: SCI
资助者: National Natural Science Foundation of China;Young Creative Sci-Tech Talents Cultivation Project of Xinjiang Uygur Autonomous Region;High-tech R&D Program of Xinjiang Uygur Autonomous Region;Chinese Academy of Sciences
摘要: An efficient method has been developed for the enantioselective synthesis of fully protected alpha-quaternary alpha-hydroxy-beta-amino esters via the coupling of three components: aryl Grignard reagents (or methyllithium), silyl glyoxylate, and N-tert-butanesulfinyl imines. This protocol enables successive formation of two C-C bonds and two adjacent chiral carbons with high stereocontrol in a one-pot operation.
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内容类型: 期刊论文
URI标识: http://ir.xjipc.cas.cn/handle/365002/3812
Appears in Collections:资源化学研究室_期刊论文

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作者单位: Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Zones, Urumqi 830011, Peoples R China

Recommended Citation:
Jiang, Jiu-Long,Yao, Ming,Lu, Chong-Dao. Efficient Synthesis of alpha-Quaternary alpha-Hydroxy-beta-amino Esters via Silyl Glyoxylate-Mediated Three-Component Reactions[J]. ORGANIC LETTERS,2014,16(1):318-321.
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文件名: Efficient Synthesis of alpha-Quaternary alpha-Hydroxy-beta-amino Esters via Silyl Glyoxylate-Mediated Three-Component Reactions.pdf
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