Synthesis, characterization, and antitumor activities of new palladium(II) complexes with 1-(alkyldithiocarbonyl)imidazoles
Hou, Xueling; Li, Xiaobo; Hemit, Helimay; Aisa, Haji Akber; Hou, XL
2014
发表期刊JOURNAL OF COORDINATION CHEMISTRY
ISSN0095-8972
卷号67期号:3页码:461-469
摘要

Pd(II) complexes with imidazole linked to dithiocarbamate derivatives were synthesized by reacting 1-(alkyldithiocarbonyl)-imidazoles with PdCl2 in a 2:1molar ratio. The complexes were characterized by elemental analyses, FT-IR, and H-1 NMR. The single crystal structure of 4 shows that the ligand is chelated by nitrogens in imidazole, instead of sulfur, to palladium. All synthesized compounds were tested for in vitro anticancer activities. Compound 5 had better activities in the HL-60 cell line and twofold better activities in the HeLa cell line than that of cisplatin.

关键词Dithiocarbamate Palladium Imidazole Antitumor Activity
DOI10.1080/00958972.2014.890717
收录类别SCI
WOS记录号WOS:000334074800004
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.xjipc.cas.cn/handle/365002/3804
专题省部共建新疆特有药用资源利用重点实验室
通讯作者Hou, XL
作者单位Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Zone, State Key Lab Basis Xinjiang Indigenous Med Plant, Urumqi, Peoples R China
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Hou, Xueling,Li, Xiaobo,Hemit, Helimay,et al. Synthesis, characterization, and antitumor activities of new palladium(II) complexes with 1-(alkyldithiocarbonyl)imidazoles[J]. JOURNAL OF COORDINATION CHEMISTRY,2014,67(3):461-469.
APA Hou, Xueling,Li, Xiaobo,Hemit, Helimay,Aisa, Haji Akber,&Hou, XL.(2014).Synthesis, characterization, and antitumor activities of new palladium(II) complexes with 1-(alkyldithiocarbonyl)imidazoles.JOURNAL OF COORDINATION CHEMISTRY,67(3),461-469.
MLA Hou, Xueling,et al."Synthesis, characterization, and antitumor activities of new palladium(II) complexes with 1-(alkyldithiocarbonyl)imidazoles".JOURNAL OF COORDINATION CHEMISTRY 67.3(2014):461-469.
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