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题名: Synthesis, characterization, and antitumor activities of new palladium(II) complexes with 1-(alkyldithiocarbonyl)imidazoles
作者: Hou, Xueling; Li, Xiaobo; Hemit, Helimay; Aisa, Haji Akber
通讯作者: Hou, XL
关键词: Dithiocarbamate ; Palladium ; Imidazole ; Antitumor activity
刊名: JOURNAL OF COORDINATION CHEMISTRY
发表日期: 2014
DOI: 10.1080/00958972.2014.890717
卷: 67, 期:3, 页:461-469
收录类别: SCI
资助者: National Natural Science Foundation of ChinaCAS/SAFEA International Partnership Program for Creative Research Teams
摘要: Pd(II) complexes with imidazole linked to dithiocarbamate derivatives were synthesized by reacting 1-(alkyldithiocarbonyl)-imidazoles with PdCl2 in a 2:1molar ratio. The complexes were characterized by elemental analyses, FT-IR, and H-1 NMR. The single crystal structure of 4 shows that the ligand is chelated by nitrogens in imidazole, instead of sulfur, to palladium. All synthesized compounds were tested for in vitro anticancer activities. Compound 5 had better activities in the HL-60 cell line and twofold better activities in the HeLa cell line than that of cisplatin.
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内容类型: 期刊论文
URI标识: http://ir.xjipc.cas.cn/handle/365002/3804
Appears in Collections:新疆维吾尔自治区植物资源化学重点实验室 _期刊论文

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作者单位: Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Zone, State Key Lab Basis Xinjiang Indigenous Med Plant, Urumqi, Peoples R China

Recommended Citation:
Hou, Xueling,Li, Xiaobo,Hemit, Helimay,et al. Synthesis, characterization, and antitumor activities of new palladium(II) complexes with 1-(alkyldithiocarbonyl)imidazoles[J]. JOURNAL OF COORDINATION CHEMISTRY,2014,67(3):461-469.
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文件名: Synthesis, characterization, and antitumor activities of new palladium(II) complexes with 1-(alkyldithiocarbonyl)imidazoles .pdf
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