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题名: Highly Conjugated Norditerpenoid and Pyrroloquinoline Alkaloids with Potent PTP1B Inhibitory Activity from Nigella glandulifera
作者: Chen, Qi-Bin; Xin, Xue-Lei; Yang, Yi; Lee, Shoei-Sheng; Aisa, H. A.
通讯作者: Aisa, HA
刊名: JOURNAL OF NATURAL PRODUCTS
发表日期: 2014
DOI: 10.1021/np4009078
卷: 77, 期:4, 页:807-812
收录类别: SCI
资助者: National Science Fund for Distinguished Young Scholars;National Natural Science Foundation of China;Projects of International Science & Techology Cooperation of the Xinjiang Uyghur Autonomous Region
摘要: Three norditerpenoid alkaloids, nigelladines A-C (1-3), and one pyrroloquinoline alkaloid, nigellaquinomine (4), all possessing new skeletons with highly conjugated systems, were isolated from Nigella glandulifera. The 8aS-configuration for 1 and 2 was determined by comparison of the experimental and calculated electronic circular dichroism spectra. These alkaloids exhibited potent protein tyrosine phosphatase 1B (PTP1B) inhibitory activity but are devoid of cytotoxicity against the A431 cell line at 100 mu M.
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内容类型: 期刊论文
URI标识: http://ir.xjipc.cas.cn/handle/365002/3794
Appears in Collections:新疆维吾尔自治区植物资源化学重点实验室 _期刊论文

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作者单位: Chinese Acad Sci, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Peoples R China;Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Basis Xinjiang Indigenous Med Plant, Urumqi 830011, Peoples R China;Univ Chinese Acad Sci, Beijing 100039, Peoples R China;Natl Taiwan Univ, Coll Med, Sch Pharm, Taipei 10051, Taiwan

Recommended Citation:
Chen, Qi-Bin,Xin, Xue-Lei,Yang, Yi,et al. Highly Conjugated Norditerpenoid and Pyrroloquinoline Alkaloids with Potent PTP1B Inhibitory Activity from Nigella glandulifera[J]. JOURNAL OF NATURAL PRODUCTS,2014,77(4):807-812.
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文件名: Highly Conjugated Norditerpenoid and Pyrroloquinoline Alkaloids with Potent PTP1B Inhibitory Activity from Nigella glandulifera .pdf
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