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Alkaloids of Nitraria sibirica Pall, decrease hypertension and albuminuria in angiotensin II-salt hypertension
Bakri, Mahinur; Yi Yang; Chen Ling-Dan; Aisa, Haji Akber; Wang Mong-Heng
2014
Source PublicationCHINESE JOURNAL OF NATURAL MEDICINES
ISSN2095-6975
Volume12Issue:4Pages:266-272
AbstractIn traditional Chinese medicine, Nitraria sibirica Pall. (Nitrariaceae) is used to treat hypertension. This study determined the effects of the total alkaloids of the leaves of Nitraria sibirica (NSTA) on blood pressure and albuminuria in mice treated with angiotensin II and a high-salt diet (ANG/HS). Adult mice were divided into three groups: control; infused with angiotensin II and fed a diet containing 4% NaCl (ANG/HS; and ANG/HS plus injection of NSTA(1 mg.kg(-1.)d(-1), i.p.)). After treatment of these regimens, daily water and food intake, kidney weight, blood pressure, urinary albumin excretion, renal concentrations of inflammatory markers, including soluble intercellular adhesion molecule-1 (sICAM-1) and monocyte chemoattractant ptotein-1 (MCP-1), and the expression of renal fibrosis markers were determined. Compared to the control group, the ANG/HS group had higher blood pressure and urinary albumin excretion. Treatment with NSTA in ANG/HS mice for three weeks significantly reduced blood pressure and urinary albumin excretion. ANG/HS treatment caused elevated levels of sICAM-1 and MCP-1, as well as increased fibrosis markers. Concurrent treatment with ANG/HS and NSTA attenuated the levels and expression of renal inflammatory and fibrosis markers. Treatment with NSTA effectively reduces hypertension-induced albuminuria through the reduction of renal inflammatory and fibrosis markers.
KeywordNitraria Sibirica Alkaloids Blood Pressure High Salt Diet Hypertension Albuminuria
Funding OrganizationWest Light Foundation of the Chinese Academy of Science;ABA DODI grant from Georgia Health Sciences University ; West Light Foundation of the Chinese Academy of Science;ABA DODI grant from Georgia Health Sciences University
DOI10.3724/SP.J.1009.2014.00266
Indexed BySCI
Funding OrganizationWest Light Foundation of the Chinese Academy of Science;ABA DODI grant from Georgia Health Sciences University ; West Light Foundation of the Chinese Academy of Science;ABA DODI grant from Georgia Health Sciences University
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Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.xjipc.cas.cn/handle/365002/3793
Collection省部共建新疆特有药用资源利用重点实验室
AffiliationChinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Peoples R China;Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Basis Xinjiang Indigenous Med Plant, Urumqi 830011, Peoples R China;Georgia Regents Univ, Dept Physiol, Augusta, GA 30912 USA
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GB/T 7714
Bakri, Mahinur,Yi Yang,Chen Ling-Dan,et al. Alkaloids of Nitraria sibirica Pall, decrease hypertension and albuminuria in angiotensin II-salt hypertension[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2014,12(4):266-272.
APA Bakri, Mahinur,Yi Yang,Chen Ling-Dan,Aisa, Haji Akber,&Wang Mong-Heng.(2014).Alkaloids of Nitraria sibirica Pall, decrease hypertension and albuminuria in angiotensin II-salt hypertension.CHINESE JOURNAL OF NATURAL MEDICINES,12(4),266-272.
MLA Bakri, Mahinur,et al."Alkaloids of Nitraria sibirica Pall, decrease hypertension and albuminuria in angiotensin II-salt hypertension".CHINESE JOURNAL OF NATURAL MEDICINES 12.4(2014):266-272.
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