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题名: Alkaloids of Nitraria sibirica Pall, decrease hypertension and albuminuria in angiotensin II-salt hypertension
作者: Bakri, Mahinur; Yi Yang; Chen Ling-Dan; Aisa, Haji Akber; Wang Mong-Heng
关键词: Nitraria sibirica ; Alkaloids ; Blood pressure ; High salt diet ; Hypertension ; Albuminuria
刊名: CHINESE JOURNAL OF NATURAL MEDICINES
发表日期: 2014
DOI: 10.3724/SP.J.1009.2014.00266
卷: 12, 期:4, 页:266-272
收录类别: SCI
资助者: West Light Foundation of the Chinese Academy of Science;ABA DODI grant from Georgia Health Sciences University
摘要: In traditional Chinese medicine, Nitraria sibirica Pall. (Nitrariaceae) is used to treat hypertension. This study determined the effects of the total alkaloids of the leaves of Nitraria sibirica (NSTA) on blood pressure and albuminuria in mice treated with angiotensin II and a high-salt diet (ANG/HS). Adult mice were divided into three groups: control; infused with angiotensin II and fed a diet containing 4% NaCl (ANG/HS; and ANG/HS plus injection of NSTA(1 mg.kg(-1.)d(-1), i.p.)). After treatment of these regimens, daily water and food intake, kidney weight, blood pressure, urinary albumin excretion, renal concentrations of inflammatory markers, including soluble intercellular adhesion molecule-1 (sICAM-1) and monocyte chemoattractant ptotein-1 (MCP-1), and the expression of renal fibrosis markers were determined. Compared to the control group, the ANG/HS group had higher blood pressure and urinary albumin excretion. Treatment with NSTA in ANG/HS mice for three weeks significantly reduced blood pressure and urinary albumin excretion. ANG/HS treatment caused elevated levels of sICAM-1 and MCP-1, as well as increased fibrosis markers. Concurrent treatment with ANG/HS and NSTA attenuated the levels and expression of renal inflammatory and fibrosis markers. Treatment with NSTA effectively reduces hypertension-induced albuminuria through the reduction of renal inflammatory and fibrosis markers.
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内容类型: 期刊论文
URI标识: http://ir.xjipc.cas.cn/handle/365002/3793
Appears in Collections:新疆维吾尔自治区植物资源化学重点实验室 _期刊论文

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作者单位: Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Peoples R China;Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Basis Xinjiang Indigenous Med Plant, Urumqi 830011, Peoples R China;Georgia Regents Univ, Dept Physiol, Augusta, GA 30912 USA

Recommended Citation:
Bakri, Mahinur,Yi Yang,Chen Ling-Dan,et al. Alkaloids of Nitraria sibirica Pall, decrease hypertension and albuminuria in angiotensin II-salt hypertension[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2014,12(4):266-272.
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