Alkaloids of Nitraria sibirica Pall, decrease hypertension and albuminuria in angiotensin II-salt hypertension
Bakri, Mahinur; Yi Yang; Chen Ling-Dan; Aisa, Haji Akber; Wang Mong-Heng
2014
发表期刊CHINESE JOURNAL OF NATURAL MEDICINES
ISSN2095-6975
卷号12期号:4页码:266-272
摘要In traditional Chinese medicine, Nitraria sibirica Pall. (Nitrariaceae) is used to treat hypertension. This study determined the effects of the total alkaloids of the leaves of Nitraria sibirica (NSTA) on blood pressure and albuminuria in mice treated with angiotensin II and a high-salt diet (ANG/HS). Adult mice were divided into three groups: control; infused with angiotensin II and fed a diet containing 4% NaCl (ANG/HS; and ANG/HS plus injection of NSTA(1 mg.kg(-1.)d(-1), i.p.)). After treatment of these regimens, daily water and food intake, kidney weight, blood pressure, urinary albumin excretion, renal concentrations of inflammatory markers, including soluble intercellular adhesion molecule-1 (sICAM-1) and monocyte chemoattractant ptotein-1 (MCP-1), and the expression of renal fibrosis markers were determined. Compared to the control group, the ANG/HS group had higher blood pressure and urinary albumin excretion. Treatment with NSTA in ANG/HS mice for three weeks significantly reduced blood pressure and urinary albumin excretion. ANG/HS treatment caused elevated levels of sICAM-1 and MCP-1, as well as increased fibrosis markers. Concurrent treatment with ANG/HS and NSTA attenuated the levels and expression of renal inflammatory and fibrosis markers. Treatment with NSTA effectively reduces hypertension-induced albuminuria through the reduction of renal inflammatory and fibrosis markers.
关键词Nitraria Sibirica Alkaloids Blood Pressure High Salt Diet Hypertension Albuminuria
资助者West Light Foundation of the Chinese Academy of Science;ABA DODI grant from Georgia Health Sciences University ; West Light Foundation of the Chinese Academy of Science;ABA DODI grant from Georgia Health Sciences University
DOI10.3724/SP.J.1009.2014.00266
收录类别SCI
资助者West Light Foundation of the Chinese Academy of Science;ABA DODI grant from Georgia Health Sciences University ; West Light Foundation of the Chinese Academy of Science;ABA DODI grant from Georgia Health Sciences University
引用统计
文献类型期刊论文
条目标识符http://ir.xjipc.cas.cn/handle/365002/3793
专题省部共建新疆特有药用资源利用重点实验室
作者单位Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Peoples R China;Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Basis Xinjiang Indigenous Med Plant, Urumqi 830011, Peoples R China;Georgia Regents Univ, Dept Physiol, Augusta, GA 30912 USA
推荐引用方式
GB/T 7714
Bakri, Mahinur,Yi Yang,Chen Ling-Dan,et al. Alkaloids of Nitraria sibirica Pall, decrease hypertension and albuminuria in angiotensin II-salt hypertension[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2014,12(4):266-272.
APA Bakri, Mahinur,Yi Yang,Chen Ling-Dan,Aisa, Haji Akber,&Wang Mong-Heng.(2014).Alkaloids of Nitraria sibirica Pall, decrease hypertension and albuminuria in angiotensin II-salt hypertension.CHINESE JOURNAL OF NATURAL MEDICINES,12(4),266-272.
MLA Bakri, Mahinur,et al."Alkaloids of Nitraria sibirica Pall, decrease hypertension and albuminuria in angiotensin II-salt hypertension".CHINESE JOURNAL OF NATURAL MEDICINES 12.4(2014):266-272.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Alkaloids of Nitrari(744KB)期刊论文作者接受稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Bakri, Mahinur]的文章
[Yi Yang]的文章
[Chen Ling-Dan]的文章
百度学术
百度学术中相似的文章
[Bakri, Mahinur]的文章
[Yi Yang]的文章
[Chen Ling-Dan]的文章
必应学术
必应学术中相似的文章
[Bakri, Mahinur]的文章
[Yi Yang]的文章
[Chen Ling-Dan]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Alkaloids of Nitraria sibirica Pall, decrease hypertension and albuminuria in angiotensin II-salt hypertension .pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。