XJIPC OpenIR  > 省部共建新疆特有药用资源利用重点实验室
Kaliziri extract upregulates tyrosinase, TRP-1, TRP-2 and MITF expression in murine B16 melanoma cells
Tuerxuntayi, Adila; Liu, Yong-qiang; Tulake, Ablajan; Kabas, Maidina; Eblimit, Aiden; Aisa, Haji Akber
2014
Source PublicationBMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
ISSN1472-6882
Volume14Issue:5Pages:1-9
Abstract

Background: Kaliziri extract (KZE) is a traditional Uyghur medicine (TUM), used by traditional hospitals in China as an injection for treatment of vitiligo for more than 30 years. Clinical application has shown that this medicine has obvious therapeutic effects. However, its phytochemical analysis and mechanism have not been examined. Methods: KZE was extracted from seeds of Kaliziri [Vernonia anthelmintica (L.) Willd.] in ethanol-water (80: 20, v/v), its components were identified by LC-MS/MS, and the signaling pathway of melanin synthesis in KZE treated murine B16 melanoma cells was examined by western blotting. Results: Liquid chromatography-mass spectrometry analysis confirmed that the main components of KZE are flavonoids. KZE increased the tyrosinase activity and melanin content in a dose-dependent manner at concentrations of 5-40 mu g/ml, and treatment with 20 mu g/ml of KZE enhanced the expression of tyrosinase in B16 cells in a time-dependent manner. Conclusions: KZE induced melanogenesis by increasing the expression of TYR, TRP-1, TRP-2 and MITF in B16 cells.

KeywordKze Melanogenesis B16 Melanoma Cells Tyr Mitf
DOI10.1186/1472-6882-14-166
Indexed BySCI
Citation statistics
Cited Times:24[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.xjipc.cas.cn/handle/365002/3782
Collection省部共建新疆特有药用资源利用重点实验室
Corresponding AuthorAisa, Haji Akber
Affiliation1.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Peoples R China
2.State Key Lab Basis Xinjiang Indigenous Med Plant, Urumqi 830011, Peoples R China
3.Baylor Coll Med, Dept Mol & Human Genet, Human Genome Sequencing Ctr, Houston, TX 77030 USA
4.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
Recommended Citation
GB/T 7714
Tuerxuntayi, Adila,Liu, Yong-qiang,Tulake, Ablajan,et al. Kaliziri extract upregulates tyrosinase, TRP-1, TRP-2 and MITF expression in murine B16 melanoma cells[J]. BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE,2014,14(5):1-9.
APA Tuerxuntayi, Adila,Liu, Yong-qiang,Tulake, Ablajan,Kabas, Maidina,Eblimit, Aiden,&Aisa, Haji Akber.(2014).Kaliziri extract upregulates tyrosinase, TRP-1, TRP-2 and MITF expression in murine B16 melanoma cells.BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE,14(5),1-9.
MLA Tuerxuntayi, Adila,et al."Kaliziri extract upregulates tyrosinase, TRP-1, TRP-2 and MITF expression in murine B16 melanoma cells".BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE 14.5(2014):1-9.
Files in This Item:
File Name/Size DocType Version Access License
Kaliziri extract upr(1085KB)期刊论文作者接受稿开放获取CC BY-NC-SAView Application Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Tuerxuntayi, Adila]'s Articles
[Liu, Yong-qiang]'s Articles
[Tulake, Ablajan]'s Articles
Baidu academic
Similar articles in Baidu academic
[Tuerxuntayi, Adila]'s Articles
[Liu, Yong-qiang]'s Articles
[Tulake, Ablajan]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Tuerxuntayi, Adila]'s Articles
[Liu, Yong-qiang]'s Articles
[Tulake, Ablajan]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Kaliziri extract upregulates tyrosinase, TRP-1, TRP-2 and MITF expression in murine B16 melanoma cells .pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.