Kaliziri extract upregulates tyrosinase, TRP-1, TRP-2 and MITF expression in murine B16 melanoma cells
Tuerxuntayi, Adila; Liu, Yong-qiang; Tulake, Ablajan; Kabas, Maidina; Eblimit, Aiden; Aisa, Haji Akber; Aisa, HA
2014
发表期刊BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
ISSN1472-6882
卷号14期号:5
摘要Background: Kaliziri extract (KZE) is a traditional Uyghur medicine (TUM), used by traditional hospitals in China as an injection for treatment of vitiligo for more than 30 years. Clinical application has shown that this medicine has obvious therapeutic effects. However, its phytochemical analysis and mechanism have not been examined. Methods: KZE was extracted from seeds of Kaliziri [Vernonia anthelmintica (L.) Willd.] in ethanol-water (80: 20, v/v), its components were identified by LC-MS/MS, and the signaling pathway of melanin synthesis in KZE treated murine B16 melanoma cells was examined by western blotting. Results: Liquid chromatography-mass spectrometry analysis confirmed that the main components of KZE are flavonoids. KZE increased the tyrosinase activity and melanin content in a dose-dependent manner at concentrations of 5-40 mu g/ml, and treatment with 20 mu g/ml of KZE enhanced the expression of tyrosinase in B16 cells in a time-dependent manner. Conclusions: KZE induced melanogenesis by increasing the expression of TYR, TRP-1, TRP-2 and MITF in B16 cells.
关键词Kze Melanogenesis B16 Melanoma Cells Tyr Mitf
资助者International Cooperation and Exchange of the National Natural Science Foundation of China;National Program on Key Basic Research Project of China (973 Program) ; International Cooperation and Exchange of the National Natural Science Foundation of China;National Program on Key Basic Research Project of China (973 Program) ; International Cooperation and Exchange of the National Natural Science Foundation of China;National Program on Key Basic Research Project of China (973 Program) ; International Cooperation and Exchange of the National Natural Science Foundation of China;National Program on Key Basic Research Project of China (973 Program)
DOI10.1186/1472-6882-14-166
收录类别SCI
资助者International Cooperation and Exchange of the National Natural Science Foundation of China;National Program on Key Basic Research Project of China (973 Program) ; International Cooperation and Exchange of the National Natural Science Foundation of China;National Program on Key Basic Research Project of China (973 Program) ; International Cooperation and Exchange of the National Natural Science Foundation of China;National Program on Key Basic Research Project of China (973 Program) ; International Cooperation and Exchange of the National Natural Science Foundation of China;National Program on Key Basic Research Project of China (973 Program)
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被引频次:22[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.xjipc.cas.cn/handle/365002/3782
专题省部共建新疆特有药用资源利用重点实验室
通讯作者Aisa, HA
作者单位Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Peoples R China;State Key Lab Basis Xinjiang Indigenous Med Plant, Urumqi 830011, Peoples R China;Baylor Coll Med, Dept Mol & Human Genet, Human Genome Sequencing Ctr, Houston, TX 77030 USA;Univ Chinese Acad Sci, Beijing 100039, Peoples R China
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Tuerxuntayi, Adila,Liu, Yong-qiang,Tulake, Ablajan,et al. Kaliziri extract upregulates tyrosinase, TRP-1, TRP-2 and MITF expression in murine B16 melanoma cells[J]. BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE,2014,14(5).
APA Tuerxuntayi, Adila.,Liu, Yong-qiang.,Tulake, Ablajan.,Kabas, Maidina.,Eblimit, Aiden.,...&Aisa, HA.(2014).Kaliziri extract upregulates tyrosinase, TRP-1, TRP-2 and MITF expression in murine B16 melanoma cells.BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE,14(5).
MLA Tuerxuntayi, Adila,et al."Kaliziri extract upregulates tyrosinase, TRP-1, TRP-2 and MITF expression in murine B16 melanoma cells".BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE 14.5(2014).
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