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题名: Kaliziri extract upregulates tyrosinase, TRP-1, TRP-2 and MITF expression in murine B16 melanoma cells
作者: Tuerxuntayi, Adila; Liu, Yong-qiang; Tulake, Ablajan; Kabas, Maidina; Eblimit, Aiden; Aisa, Haji Akber
通讯作者: Aisa, HA
关键词: KZE ; Melanogenesis ; B16 melanoma cells ; TYR ; MITF
刊名: BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
发表日期: 2014
DOI: 10.1186/1472-6882-14-166
卷: 14, 期:5
收录类别: SCI
资助者: International Cooperation and Exchange of the National Natural Science Foundation of China;National Program on Key Basic Research Project of China (973 Program)
摘要: Background: Kaliziri extract (KZE) is a traditional Uyghur medicine (TUM), used by traditional hospitals in China as an injection for treatment of vitiligo for more than 30 years. Clinical application has shown that this medicine has obvious therapeutic effects. However, its phytochemical analysis and mechanism have not been examined. Methods: KZE was extracted from seeds of Kaliziri [Vernonia anthelmintica (L.) Willd.] in ethanol-water (80: 20, v/v), its components were identified by LC-MS/MS, and the signaling pathway of melanin synthesis in KZE treated murine B16 melanoma cells was examined by western blotting. Results: Liquid chromatography-mass spectrometry analysis confirmed that the main components of KZE are flavonoids. KZE increased the tyrosinase activity and melanin content in a dose-dependent manner at concentrations of 5-40 mu g/ml, and treatment with 20 mu g/ml of KZE enhanced the expression of tyrosinase in B16 cells in a time-dependent manner. Conclusions: KZE induced melanogenesis by increasing the expression of TYR, TRP-1, TRP-2 and MITF in B16 cells.
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内容类型: 期刊论文
URI标识: http://ir.xjipc.cas.cn/handle/365002/3782
Appears in Collections:新疆维吾尔自治区植物资源化学重点实验室 _期刊论文

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作者单位: Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Peoples R China;State Key Lab Basis Xinjiang Indigenous Med Plant, Urumqi 830011, Peoples R China;Baylor Coll Med, Dept Mol & Human Genet, Human Genome Sequencing Ctr, Houston, TX 77030 USA;Univ Chinese Acad Sci, Beijing 100039, Peoples R China

Recommended Citation:
Tuerxuntayi, Adila,Liu, Yong-qiang,Tulake, Ablajan,et al. Kaliziri extract upregulates tyrosinase, TRP-1, TRP-2 and MITF expression in murine B16 melanoma cells[J]. BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE,2014,14(5).
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