中国科学院新疆理化技术研究所机构知识库
Advanced  
XJIPC OpenIR  > 资源化学研究室  > 期刊论文
题名: 异叶青兰总黄酮对高血压大鼠血管内皮的保护作用
其他题名: Protective effect of Dracocephalum heterophyllum Benth.on blood vessel endothelium of hypertensive rats
作者: 何雯; 邬利娅·伊明; 司丽君; 闫冬; 王雪飞; 萨迪克·诺莫诺夫; 帕尔哈提·克热木
关键词: 异叶青兰总黄酮 ; 高血压 ; 血管内皮 ; Dracocephalum heterophyllum Benth flavonoid ; hypertension ; vascular endothelial
刊名: 中国医院药学杂志
发表日期: 2013
DOI: 10.13286/j.cnki.chinhosppharmacyj.2013.15.008
卷: 33, 期:15, 页:1226-1228
收录类别: CSCD
资助者: 新疆维吾尔自治区自然科学基金项目;省部共建国家重点实验室培育基地新疆特有药用资源利用实验室开放课题项目;新疆医科大学校级创新基金项目
摘要: 目的:研究异叶青兰总黄酮(Dracocephalumheterophyllum Benth flavonoid,DHBF)对高血压大鼠血管内皮的保护作用.方法:左肾动脉狭窄法建立“两肾一夹”高血压大鼠模型,设假手术组(Sham),模型组(Model),异叶青兰总黄酮低剂量组(DHBF-L)300 mg·kg 1·d-1、高剂量组(DHBF-H)600 mg·kg-1·d-1,卡托普利组(Captopril)20 mg·kg-1·d-1.灌胃给药6周,每周无创尾套法测量大鼠尾动脉收缩压.硝酸还原酶法测定血清中一氧化氮(NO)水平,放射免疫法测定心肌中ET-1含量,血浆中TXB2、6-keto-PGF1.含量,计算其比值.结果:异叶青兰总黄酮两剂量组能明显降低肾性高血压大鼠尾动脉收缩压(P<0.05,P<0.01),升高NO水平(P<0.05,P<0.01),降低ET水平(P<0.01),降低TXB2与6-keto-PGF1α比值(P<0.05).结论:异叶青兰总黄酮对高血压大鼠的血管内皮具有一定的保护作用.
英文摘要: OBJECTIVE To study the protective effect of Dracocephalum heterophyllum Benth flavonoid(DHBF)on blood zvessel endothelium of hypertensive rats.METHODS Two-kidney-one-clip hypertensive rats were obtained by narrowing left zkidney arteries.5groups were divided as sham;model;DHBF low dose group(DHBF-L,300mg·kg~(-1)·d~(-1));DHBF high zdose group(DHBF-H,600mg·kg~(-1)·d~(-1))and captopril(20mg·kg~(-1))group.The drugs were given by intragastric administration z for 6weeks.Systolic blood pressure(SBP)was measured by tail cuff approach every week.After the sixth week,,the zlevels of NO in serum were measured by nitrate reductase method,The levels of ET in heart,TXB_2,6-keto-PGF_(1alpha) in plasma zwere all measured by radioimmunoassay and the ratio of TXB_2 and 6-keto-PGF_(1alpha) were calculated.RESULTS DHBF significantly z reduced hypertensive ratsblood pressure(P<0.05,P<0.01),increased the concentration of NO (P<0.05,P<0.01) zwhile decreased the content of ET(P<0.01);reduced the ratio of TXB_2 and 6-keto-PGF_1((P<0.05).CONCLUSION The results z suggest that DHBF could be used to protect blood vessel endothelium of hypertensive rats.
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.xjipc.cas.cn/handle/365002/3711
Appears in Collections:资源化学研究室_期刊论文

Files in This Item:
File Name/ File Size Content Type Version Access License
异叶青兰总黄酮对高血压大鼠血管内皮的保护作用.pdf(387KB)期刊论文作者接受稿开放获取View 联系获取全文

作者单位: 新疆医科大学基础医学院药理教研室;新疆医科大学第五附属医院药剂科;新疆医科大学基础医学院生理教研室;中国科学院新疆理化技术研究所

Recommended Citation:
何雯,邬利娅·伊明,司丽君,等. 异叶青兰总黄酮对高血压大鼠血管内皮的保护作用[J]. 中国医院药学杂志,2013,33(15):1226-1228.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[何雯]'s Articles
[邬利娅·伊明]'s Articles
[司丽君]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[何雯]‘s Articles
[邬利娅·伊明]‘s Articles
[司丽君]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: 异叶青兰总黄酮对高血压大鼠血管内皮的保护作用.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace