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Alternative TitleProtective effect of Dracocephalum heterophyllum Benth.on blood vessel endothelium of hypertensive rats
何雯; 邬利娅·伊明; 司丽君; 闫冬; 王雪飞; 萨迪克·诺莫诺夫; 帕尔哈提·克热木
Source Publication中国医院药学杂志
Abstract目的:研究异叶青兰总黄酮(Dracocephalumheterophyllum Benth flavonoid,DHBF)对高血压大鼠血管内皮的保护作用.方法:左肾动脉狭窄法建立“两肾一夹”高血压大鼠模型,设假手术组(Sham),模型组(Model),异叶青兰总黄酮低剂量组(DHBF-L)300 mg·kg 1·d-1、高剂量组(DHBF-H)600 mg·kg-1·d-1,卡托普利组(Captopril)20 mg·kg-1·d-1.灌胃给药6周,每周无创尾套法测量大鼠尾动脉收缩压.硝酸还原酶法测定血清中一氧化氮(NO)水平,放射免疫法测定心肌中ET-1含量,血浆中TXB2、6-keto-PGF1.含量,计算其比值.结果:异叶青兰总黄酮两剂量组能明显降低肾性高血压大鼠尾动脉收缩压(P<0.05,P<0.01),升高NO水平(P<0.05,P<0.01),降低ET水平(P<0.01),降低TXB2与6-keto-PGF1α比值(P<0.05).结论:异叶青兰总黄酮对高血压大鼠的血管内皮具有一定的保护作用.
Other AbstractOBJECTIVE To study the protective effect of Dracocephalum heterophyllum Benth flavonoid(DHBF)on blood zvessel endothelium of hypertensive rats.METHODS Two-kidney-one-clip hypertensive rats were obtained by narrowing left zkidney arteries.5groups were divided as sham;model;DHBF low dose group(DHBF-L,300mg·kg~(-1)·d~(-1));DHBF high zdose group(DHBF-H,600mg·kg~(-1)·d~(-1))and captopril(20mg·kg~(-1))group.The drugs were given by intragastric administration z for 6weeks.Systolic blood pressure(SBP)was measured by tail cuff approach every week.After the sixth week,,the zlevels of NO in serum were measured by nitrate reductase method,The levels of ET in heart,TXB_2,6-keto-PGF_(1alpha) in plasma zwere all measured by radioimmunoassay and the ratio of TXB_2 and 6-keto-PGF_(1alpha) were calculated.RESULTS DHBF significantly z reduced hypertensive ratsblood pressure(P<0.05,P<0.01),increased the concentration of NO (P<0.05,P<0.01) zwhile decreased the content of ET(P<0.01);reduced the ratio of TXB_2 and 6-keto-PGF_1((P<0.05).CONCLUSION The results z suggest that DHBF could be used to protect blood vessel endothelium of hypertensive rats.
Keyword异叶青兰总黄酮 高血压 血管内皮 Dracocephalum Heterophyllum Benth Flavonoid Hypertension Vascular Endothelial
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Document Type期刊论文
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何雯,邬利娅·伊明,司丽君,等. 异叶青兰总黄酮对高血压大鼠血管内皮的保护作用[J]. 中国医院药学杂志,2013,33(15):1226-1228.
APA 何雯.,邬利娅·伊明.,司丽君.,闫冬.,王雪飞.,...&帕尔哈提·克热木.(2013).异叶青兰总黄酮对高血压大鼠血管内皮的保护作用.中国医院药学杂志,33(15),1226-1228.
MLA 何雯,et al."异叶青兰总黄酮对高血压大鼠血管内皮的保护作用".中国医院药学杂志 33.15(2013):1226-1228.
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