OBJECTIVE:To study the protective effects of Caper capsules on acute liver injury model mice and its effect on bile secretion in rats. METHODS:Chemical liver injury mice model was induced by intraperitoneal injection of carbon tetrachloride(CCl_4)or galactosamine(GaIN);immunological liver injury mice model was induced by bacillus calmette-guerin(BCG)plus lipopolysaccharide(LPS). The activities of ALT and AST were determined;pathological examination of liver tissue was conducted. The secretion of bile in rats was determined by means of common bile duct drainage. RESULTS:Compared with normal control group,the activities of ALT and AST were increased in model group;there was statistical significance(P<0.01);all mice suffered from severe liver injury. Compared with model group,the activities of ALT and ADR were relieved in Caper capsules high-dose, medium-dose and low-dose groups;there was statistical significance(P<0.01 or P<0.05);liver injury of mice was relieved to some extent. Treatment with Caper capsules 0.58 g/kg can promote bile secretion in normal rats during 2-2.5h. CONCLUSIONS: Caper capsules are the potent hepatoprotective medicine and have an obvious cholagogic effect,which may associated with anti-inflammation and immunity enhancement.