XJIPC OpenIR  > 资源化学研究室
Thesis Advisor高林、赵文军
Degree Grantor中国科学院研究生院
Place of Conferral北京
Degree Name硕士
Degree Discipline材料物理与化学
Keyword苯乙烯-马来酸酐共聚物水凝胶 Ph敏感性 温度敏感性 离子强度敏感性 动态溶涨性能 缓释 药物释放


Other Abstract
Styrene/maleic anhydride copolymer-g-PEG400 (SMA-g-PEG400) hydrogels were synthesized and characterized by FT-IR. Influence of environmental pH value, temperature and ionic strength on swelling performance of the hydrogels had been investigated. Especially,its dynamic swelling mechanism had been researched. The result showed that these hydrogels made a quick volume response to the changing of pH value, temperature and ionic strength, which showed some features of intelligent gel. The paper chose erythromycin as the model medicines and investigated the drug release behavior of SMA-g-PEG400 at different medium ,pH=1 and pH=6.8 respectively. Result showed the cumulative release ratio at pH=6.8 was higher than at pH=1. Based on the result of drug release , conclusion could be arrived at: if the crosslinking point density and esterification degree of SMA-g-PEG400 be controlled properly, the sustained-release hydrogel SMA-g-PEG400 possessing proper release speed which were demanded by medicine industry could be gained.
Document Type学位论文
Recommended Citation
GB/T 7714
孙成栋. 苯乙烯—马来酸酐共聚物智能水凝胶的制备与性能[D]. 北京. 中国科学院研究生院,2008.
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苯乙烯—马来酸酐共聚物智能水凝胶的制备与(568KB)学位论文 开放获取CC BY-NC-SAApplication Full Text
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