中国科学院新疆理化技术研究所机构知识库
Advanced  
XJIPC OpenIR  > 资源化学研究室  > 学位论文
题名: 萨乌尔翠雀花化学成分研究
作者: 顾冬雨
答辩日期: 2007-06
导师: 阿吉艾克拜尔·艾萨
专业: 有机化学
授予单位: 中国科学院研究生院
授予地点: 北京
学位: 硕士
关键词: 萨乌尔翠雀花 ; 二萜生物碱 ; 高效液相色谱法 ; 含量测定 ; 高速逆流色谱法 ; 高飞燕草碱
摘要: 萨乌尔翠雀花(Delphinium Shawurense W.T.Wang)系毛茛科翠雀属植物,此属植物多具有镇痛、镇静、去风湿、杀虫等功效,为民间药用。为了对该药用植物资源进行深入的科学研究,寻找高活性的天然产物,我们采用生物碱的分离方法对萨乌尔翠雀花进行了化学成分研究。经过研究,我们从该植物中分离出6个单体化合物,通过MS,NMR等光谱数据和理化常数确定了其中5个,它们分别为:萨乌尔翠雀碱(Shawurenine,DS-1),高飞燕草碱(Elatine,DS-2),德布灵(Delbruline,DS-3),甲基牛扁碱(Methyllycaconitine,DS-4), β-谷甾醇(β-Sitosterol,DS-5),其中DS-1为新的化合物,其它均为首次在该植物中分离得到。另外,通过高效液相色谱法对萨乌尔翠雀花中高飞燕草碱的含量进行了测定,结果表明含量与峰面积线性关系良好,平均回收率为97.1%,RSD为2.2%。该方法简便,重复性好,其他组分对测定无干扰,可用于测定萨乌尔翠雀花全草中高飞燕草碱的含量。研究用HSCCC从萨乌尔翠雀花粗提物中分离高飞燕草碱的方法,该方法简便可靠,产品纯度为97%,回收率为95%,可用于高飞燕草碱标准品的制备。
英文摘要: Delphinium Shawurense belongs to Delphinium plant of Ranunculaceae, this species have been employed in analgesic balms,sedatives,antirheumatism and antihelminthics in folk medicine. In order to develop their medical value, and find active compounds, we studied on the chemical constituents of this plant. In our work, a new alkaloid shawurensine (1) together with three known alkaloids elatine(2), delbruline(3), methyllycaconitine(4) and β-Sitosterol(5) were isolated from it. The known alkaloids were determined by comparison of physics data and NMR spectral data with those previously reported. Delphinium shawurense were studied for the first time. We find a new norditerpenoid alkaloid shawurensine. RP-HPLC was adopted to measure the determination of Elatine of Delphinium shawurense. The linear range of the standard sample was good, the average recovery was 97.1% and RSD was 2.26%, respectively. This method is sample, practical, accurate and suitable for the determination. HSCCC was used for the separation of Elatine from Delphinium shawurense’s crude sample, purity of the product was more than 97%, and recovery was 95%.
内容类型: 学位论文
URI标识: http://ir.xjipc.cas.cn/handle/365002/3490
Appears in Collections:资源化学研究室_学位论文

Files in This Item:
File Name/ File Size Content Type Version Access License
顾冬雨硕士论文.pdf(1264KB)学位论文--暂不开放View 联系获取全文

作者单位: 中国科学院新疆理化技术研究所

Recommended Citation:
顾冬雨. 萨乌尔翠雀花化学成分研究[D]. 北京. 中国科学院研究生院. 2007.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[顾冬雨]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[顾冬雨]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: 顾冬雨硕士论文.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace