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一枝蒿酮酸异噁唑酰胺类衍生物及其制备方法和用途
阿吉艾克拜尔.艾萨; 赵江瑜
2013-08-07
Rights Holder中国科学院新疆理化技术研究所
Date Available2013-11-27
Country中国
Subtype发明
Abstract本发明涉及一枝蒿酮酸异噁唑酰胺类衍生物及其制备方法和用途,该类衍生物是由一枝蒿酮酸和3-取代苯基-5-氨甲基-异噁唑衍生物为原料,在缩合剂N, N-二环己基碳二酰亚胺的作用下合成而得,并对所合成的衍生物进行了初步的体外抗甲(H3N2, H1N1)和乙型流感病毒活性测试。实验结果表明,化合物2c(N-[(3-对氟苯基-异噁唑-5-基)-甲基]-一枝蒿酮酸酰胺)对甲型H3N2流感病毒表现出一定的抑制活性;化合物2c(N-[(3-对氟苯基-异噁唑-5-基)-甲基]-一枝蒿酮酸酰胺)和2e(N-[(3-邻甲氧基苯基-异噁唑-5-基)-甲基]-一枝蒿酮酸酰胺)对乙型流感病毒表现出一定的抑制活性。该方法反应条件温和,实验步骤简捷。
Application Date2011-07-28
Patent NumberZL201110213499.0
Status授权
Application Number201110213499.0
Document Type专利
Identifierhttp://ir.xjipc.cas.cn/handle/365002/3324
Collection资源化学研究室
Recommended Citation
GB/T 7714
阿吉艾克拜尔.艾萨,赵江瑜. 一枝蒿酮酸异噁唑酰胺类衍生物及其制备方法和用途. ZL201110213499.0[P]. 2013-08-07.
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