XJIPC OpenIR  > 资源化学研究室
芳基四唑糖基衍生物及其制备方法和用途
贺耀武; 阿吉艾克拜尔.艾萨; 窦君
2013-04-03
Rights Holder中国科学院新疆理化技术研究所
Date Available2013-11-27
Country中国
Subtype发明
Abstract本发明涉及一种芳基四唑糖基衍生物及其制备方法和用途,该化合物以S-(1-芳基-1H-四唑-5-基)巯乙酰肼和糖基异硫氰酸酯为原料,合成中间体,在醋酸汞和乙醇或乙酸酐和磷酸体系中关环,分别生成含乙酰基的2-(1-芳基-1H-四唑-5-硫亚甲基)-5-糖氨基-1,3,4-噁二唑Ⅰ或2-(1-芳基-1H-四唑-5-硫亚甲基)-5-糖氨基-1,3,4-噻二唑Ⅱ,然后在甲醇钠和甲醇溶液中脱去乙酰基,分别生成不含乙酰基的2-(1-芳基-1H-四唑-5-硫亚甲基)-5-糖氨基-1,3,4-噁二唑Ⅰ或2-(1-芳基-1H-四唑-5-硫亚甲基)-5-糖氨基-1,3,4-噻二唑Ⅱ。该芳基四唑的糖基衍生物对PTP1B有很好的抑制作用,对金黄色葡萄球菌和大肠杆菌等微生物也具有较好的抑制作用。
Application Date2009-11-04
Patent NumberZL200910113508.1
Status授权
Application Number200910113508.1
Document Type专利
Identifierhttp://ir.xjipc.cas.cn/handle/365002/3032
Collection资源化学研究室
Recommended Citation
GB/T 7714
贺耀武,阿吉艾克拜尔.艾萨,窦君. 芳基四唑糖基衍生物及其制备方法和用途. ZL200910113508.1[P]. 2013-04-03.
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