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学科主题: Neurosciences & Neurology
题名: Gossypium herbaceam L. Extracts Ameliorate Disequilibrium of IL-1RA/IL-1 beta Ratio to Attenuate Inflammatory Process induced by Amyloid beta in Rats
作者: Ji Chao; Song Cai; Aisa Haji Akber; Yang Nan; Liu Yan-Yong; Li Qing; Zhu Hai-Bo; Zuo Ping-Ping
关键词: Alzheimer's disease (AD) ; Amyloid beta (A beta) ; Gossypium herbaceam L. ; IL-1 beta ; IL-1RA
刊名: CURRENT ALZHEIMER RESEARCH
发表日期: 2012
卷: 9, 期:8, 页:953-961
收录类别: SCI
资助者: National Natural Sciences Foundation of China (NSFC) 81100801; National Novel Drug Development Foundation 2009ZX09303-008; National 973 Fundamental Project of China 2007CB507400, 2010CB934002; Youth foundation from Institute of Basic Medical Sciences, Peking Union Medical College
摘要: A chronic inflammatory response possibly mediated by Amyloid beta (A beta) is believed to be a major factor in the pathology of Alzheimer's disease (AD). Studies suggest that the mediators of the inflammatory response, which might contribute to brain damage, involve cytokines, such as IL-1 beta. IL-1 beta could play an important part in the development of pathologic conditions. There is also an endogenous interleukin-1 receptor antagonist (IL-1RA) in IL-1 family, which could prevent the actions of IL-1 beta by competing for receptor binding without inducing any signal transduction. Therefore, the balance of IL-1 beta vs IL-1RA is a critical parameter in determining not only whether excessive host inflammation will occur, but also the degree of subsequent host cell damage and associated toxicity. In our previous study, it has been determined that the anti-inflammatory action of Gossypium herbaceam L. extracts (GHE) was involved in its neuroprotection. However, the effects of GHE on IL-1 beta and IL-1RA have not been clearly defined in the experimental rat model of AD induced by A beta. Therefore, the current study is performed to evaluate whether GHE could affect the disequilibrium of IL-1RA/IL-1 beta ratio in the hippocampus of rats after A beta treatment. Subsequently, we further identify that GHE could efficaciously promote Akt and GSK3 beta phosphorylation, and thereby contribute to IL-1 beta release decrease as well as a concurrent increase in the level of IL-1RA through NF-kappa B and MAPK pathways. As a consequence, GHE is potentially beneficial to maintain the endogenous IL-1RA/IL-1 beta balance in the hippocampus of rats and it might be a potential agent to ameliorate inflammatory process in AD.
内容类型: 期刊论文
URI标识: http://ir.xjipc.cas.cn/handle/365002/3025
Appears in Collections:资源化学研究室_期刊论文

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作者单位: Peking Union Med Coll, Dept Pharmacol, Sch Basic Med, Beijing 100005, Peoples R China;Chinese Acad Med Sci, Inst Basic Med Sci, Beijing 100005, Peoples R China;Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China;Peking Union Med Coll, Beijing 100050, Peoples R China;Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Urumqi 830011, Peoples R China;Univ Prince Edward Isl, AVC, Dept Biomed Sci, Charlottetown, PE C1A 4P3, Canada;Canada Natl Res Inst Nutrisci & Hlth, Charlottetown, PE C1A 4P3, Canada

Recommended Citation:
Ji Chao,Song Cai,Aisa Haji Akber,et al. Gossypium herbaceam L. Extracts Ameliorate Disequilibrium of IL-1RA/IL-1 beta Ratio to Attenuate Inflammatory Process induced by Amyloid beta in Rats[J]. CURRENT ALZHEIMER RESEARCH,2012,9(8):953-961.
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