Mechanisms of vasorelaxation induced by Ziziphora clinopodioides Lam. (Lamiaceae) extract in rat thoracic aorta
Senejoux Francois; Girard Corinne; Kerram Parhat; Aisa Haji Akber; Berthelot Alain; Bevalot Francoise; Demougeot Celine
2010
发表期刊JOURNAL OF ETHNOPHARMACOLOGY
ISSN0378-8741
卷号132期号:1页码:268-273
摘要Aim of the study: Ziziphora clinopodioides Lam. (ZC) is widely used in Uyghur folk medicine for the treatment of hypertension diseases in Xinjiang, an autonomous region of China. To provide pharmacological basis for this traditional use, we explored the vasodilating effects of ZC and investigated the underlying mechanisms. Materials and methods: Activity of hexane (ZCHE), dichloromethane (ZCDE) and aqueous (ZCAE) extracts of ZC were evaluated on isolated rat aortic rings pre-contracted with phenylephrine (PE) or high KCl. The mechanisms were evaluated on ZCDE, the most potent extract. Results: ZCDE-induced relaxation in endothelium-intact aortic rings pre-contracted with phenylephrine (PE, 10(-6) M) or high KCl (6 x 10(-2)M), with respective EC(50) values of 0.27 +/- 0.03 and 0.34 +/- 0.04g/l. Mechanic removal of the endothelium did not significantly modify ZCDE-induced relaxation. In endothelium-denuded aorta pre-contracted with PE (10(-6) M), the vasorelaxant effect of ZCDE was significantly decreased by 4-amino-pyridine (10(-3) M), but not by glibenclamide (10(-4)M), iberiotoxin (3 x 10(-8) M) and thapsigargin (10(-7) M). In Ca(2+) free solution, ZCDE significantly inhibited extracellular Ca(2+)-induced contraction in high KCl and PE pre-contracted rings. Additionally ZDCE inhibited the intracellular Ca(2+) release sensitive to PE (10(-6) M). Conclusions: The results demonstrate that ZDCE exhibits endothelium-independent vasodilating properties that are mediated by inhibition of extracellular Ca(2+) influx through voltage- and receptor-operated Ca2+ channels (VDDCs and ROCCs), by inhibition of Ca(2+) release from intracellular stores, and also by the opening of voltage-dependent K(+) channels. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
关键词Ziziphora Clinopodioides Lam. Uyghur Traditional Medicine Hypertension Mechanisms Vasorelaxant
学科领域Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
DOI10.1016/j.jep.2010.08.028
收录类别SCI
WOS记录号WOS:000284442100033
引用统计
被引频次:20[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.xjipc.cas.cn/handle/365002/2818
专题省部共建新疆特有药用资源利用重点实验室
作者单位UFR Sci Med & Pharmaceut, EA Sci Separat Biol & Pharmaceut 4267, F-25030 Besancon, France;Xinjiang Med Univ, Urumqi, Xinjiang, Peoples R China;Chinese Acad Sci, Xinjiang Key Lab Plant Resources & Nat Prod Chem, Xinjiang Tech Inst Phys & Chem, Urumqi 830011, Peoples R China
推荐引用方式
GB/T 7714
Senejoux Francois,Girard Corinne,Kerram Parhat,et al. Mechanisms of vasorelaxation induced by Ziziphora clinopodioides Lam. (Lamiaceae) extract in rat thoracic aorta[J]. JOURNAL OF ETHNOPHARMACOLOGY,2010,132(1):268-273.
APA Senejoux Francois.,Girard Corinne.,Kerram Parhat.,Aisa Haji Akber.,Berthelot Alain.,...&Demougeot Celine.(2010).Mechanisms of vasorelaxation induced by Ziziphora clinopodioides Lam. (Lamiaceae) extract in rat thoracic aorta.JOURNAL OF ETHNOPHARMACOLOGY,132(1),268-273.
MLA Senejoux Francois,et al."Mechanisms of vasorelaxation induced by Ziziphora clinopodioides Lam. (Lamiaceae) extract in rat thoracic aorta".JOURNAL OF ETHNOPHARMACOLOGY 132.1(2010):268-273.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
mechanisms of vasore(457KB)期刊论文作者接受稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Senejoux Francois]的文章
[Girard Corinne]的文章
[Kerram Parhat]的文章
百度学术
百度学术中相似的文章
[Senejoux Francois]的文章
[Girard Corinne]的文章
[Kerram Parhat]的文章
必应学术
必应学术中相似的文章
[Senejoux Francois]的文章
[Girard Corinne]的文章
[Kerram Parhat]的文章
相关权益政策
暂无数据
收藏/分享
文件名: mechanisms of vasorelaxation induced by ziziphora clinopodioides lam. (lamiaceae) extract in rat thoracic aorta.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。