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学科主题: Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
题名: Mechanisms of vasorelaxation induced by Ziziphora clinopodioides Lam. (Lamiaceae) extract in rat thoracic aorta
作者: Senejoux Francois; Girard Corinne; Kerram Parhat; Aisa Haji Akber; Berthelot Alain; Bevalot Francoise; Demougeot Celine
关键词: Ziziphora clinopodioides Lam. ; Uyghur ; Traditional medicine ; Hypertension ; Mechanisms ; Vasorelaxant
刊名: JOURNAL OF ETHNOPHARMACOLOGY
发表日期: 2010
DOI: 10.1016/j.jep.2010.08.028
卷: 132, 期:1, 页:268-273
收录类别: SCI
资助者: Region of Franche-Comte; French Ministry of Foreign and European Affairs
摘要: Aim of the study: Ziziphora clinopodioides Lam. (ZC) is widely used in Uyghur folk medicine for the treatment of hypertension diseases in Xinjiang, an autonomous region of China. To provide pharmacological basis for this traditional use, we explored the vasodilating effects of ZC and investigated the underlying mechanisms. Materials and methods: Activity of hexane (ZCHE), dichloromethane (ZCDE) and aqueous (ZCAE) extracts of ZC were evaluated on isolated rat aortic rings pre-contracted with phenylephrine (PE) or high KCl. The mechanisms were evaluated on ZCDE, the most potent extract. Results: ZCDE-induced relaxation in endothelium-intact aortic rings pre-contracted with phenylephrine (PE, 10(-6) M) or high KCl (6 x 10(-2)M), with respective EC(50) values of 0.27 +/- 0.03 and 0.34 +/- 0.04g/l. Mechanic removal of the endothelium did not significantly modify ZCDE-induced relaxation. In endothelium-denuded aorta pre-contracted with PE (10(-6) M), the vasorelaxant effect of ZCDE was significantly decreased by 4-amino-pyridine (10(-3) M), but not by glibenclamide (10(-4)M), iberiotoxin (3 x 10(-8) M) and thapsigargin (10(-7) M). In Ca(2+) free solution, ZCDE significantly inhibited extracellular Ca(2+)-induced contraction in high KCl and PE pre-contracted rings. Additionally ZDCE inhibited the intracellular Ca(2+) release sensitive to PE (10(-6) M). Conclusions: The results demonstrate that ZDCE exhibits endothelium-independent vasodilating properties that are mediated by inhibition of extracellular Ca(2+) influx through voltage- and receptor-operated Ca2+ channels (VDDCs and ROCCs), by inhibition of Ca(2+) release from intracellular stores, and also by the opening of voltage-dependent K(+) channels. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
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内容类型: 期刊论文
URI标识: http://ir.xjipc.cas.cn/handle/365002/2818
Appears in Collections:新疆维吾尔自治区植物资源化学重点实验室 _期刊论文

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作者单位: UFR Sci Med & Pharmaceut, EA Sci Separat Biol & Pharmaceut 4267, F-25030 Besancon, France;Xinjiang Med Univ, Urumqi, Xinjiang, Peoples R China;Chinese Acad Sci, Xinjiang Key Lab Plant Resources & Nat Prod Chem, Xinjiang Tech Inst Phys & Chem, Urumqi 830011, Peoples R China

Recommended Citation:
Senejoux Francois,Girard Corinne,Kerram Parhat,et al. Mechanisms of vasorelaxation induced by Ziziphora clinopodioides Lam. (Lamiaceae) extract in rat thoracic aorta[J]. JOURNAL OF ETHNOPHARMACOLOGY,2010,132(1):268-273.
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文件名: mechanisms of vasorelaxation induced by ziziphora clinopodioides lam. (lamiaceae) extract in rat thoracic aorta.pdf
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