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Chemical Modification of Rupestonic Acid and Preliminarily In Vitro Antiviral Activity Against Influenza A(3) and B Viruses
Yong Jian-ping; Aisa Haji Akber; Aisa, HA
2011
Source PublicationBULLETIN OF THE KOREAN CHEMICAL SOCIETY
ISSN0253-2964
Volume32Issue:4Pages:1293-1297
AbstractTo improve the biological activities of rupestonic acid, 21 new rupestonic acid fatty ester derivatives (2a-2h) and aromatic ester derivatives (2i-2u) were synthesized and preliminarily evaluated for their anti-influenza activity in vitro by the national center for drug screening of China, using the Oseltamivir and Ribavirin as reference drugs. The results showed that 21(IC50= 0.5 mu mol/L) exhibited potent anti-influenza A(3) viral activity among the synthesized compounds and was 10-fold more potent than that of the reference drug Oseltamivir (IC50 = 5.1 mu mol/L).
KeywordSynthesis Rupestonic Acid Ester Derivatives Anti-influenza Virus
Subject AreaChemistry
DOI10.5012/bkcs.2011.32.4.1293
Indexed BySCI
WOS IDWOS:000290366200035
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.xjipc.cas.cn/handle/365002/2783
Collection省部共建新疆特有药用资源利用重点实验室
Corresponding AuthorAisa, HA
AffiliationChinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Nat Prod Chem, Urumqi 830011, Peoples R China;Ningxia Med Univ, Sch Publ Hlth, Yinchuan 750004, Peoples R China
Recommended Citation
GB/T 7714
Yong Jian-ping,Aisa Haji Akber,Aisa, HA. Chemical Modification of Rupestonic Acid and Preliminarily In Vitro Antiviral Activity Against Influenza A(3) and B Viruses[J]. BULLETIN OF THE KOREAN CHEMICAL SOCIETY,2011,32(4):1293-1297.
APA Yong Jian-ping,Aisa Haji Akber,&Aisa, HA.(2011).Chemical Modification of Rupestonic Acid and Preliminarily In Vitro Antiviral Activity Against Influenza A(3) and B Viruses.BULLETIN OF THE KOREAN CHEMICAL SOCIETY,32(4),1293-1297.
MLA Yong Jian-ping,et al."Chemical Modification of Rupestonic Acid and Preliminarily In Vitro Antiviral Activity Against Influenza A(3) and B Viruses".BULLETIN OF THE KOREAN CHEMICAL SOCIETY 32.4(2011):1293-1297.
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