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学科主题: Chemistry
题名: Chemical Modification of Rupestonic Acid and Preliminarily In Vitro Antiviral Activity Against Influenza A(3) and B Viruses
作者: Yong Jian-ping; Aisa Haji Akber
通讯作者: Aisa, HA
关键词: Synthesis ; Rupestonic acid ester derivatives ; Anti-influenza virus
刊名: BULLETIN OF THE KOREAN CHEMICAL SOCIETY
发表日期: 2011
DOI: 10.5012/bkcs.2011.32.4.1293
卷: 32, 期:4, 页:1293-1297
收录类别: SCI
资助者: National Nature and Science Foundation 20872174; Scientific-Research Plan of the Xinjiang High Technology 200910105
摘要: To improve the biological activities of rupestonic acid, 21 new rupestonic acid fatty ester derivatives (2a-2h) and aromatic ester derivatives (2i-2u) were synthesized and preliminarily evaluated for their anti-influenza activity in vitro by the national center for drug screening of China, using the Oseltamivir and Ribavirin as reference drugs. The results showed that 21(IC50= 0.5 mu mol/L) exhibited potent anti-influenza A(3) viral activity among the synthesized compounds and was 10-fold more potent than that of the reference drug Oseltamivir (IC50 = 5.1 mu mol/L).
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内容类型: 期刊论文
URI标识: http://ir.xjipc.cas.cn/handle/365002/2783
Appears in Collections:新疆维吾尔自治区植物资源化学重点实验室 _期刊论文

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作者单位: Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Nat Prod Chem, Urumqi 830011, Peoples R China;Ningxia Med Univ, Sch Publ Hlth, Yinchuan 750004, Peoples R China

Recommended Citation:
Yong Jian-ping,Aisa Haji Akber. Chemical Modification of Rupestonic Acid and Preliminarily In Vitro Antiviral Activity Against Influenza A(3) and B Viruses[J]. BULLETIN OF THE KOREAN CHEMICAL SOCIETY,2011,32(4):1293-1297.
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文件名: chemical modification of rupestonic acid and preliminarily in vitro antiviral activity against influenza a3 and b viruses.pdf
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