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学科主题: Biochemistry & Molecular Biology ; Chemistry
题名: Preparation and characterization of grafted imprinted monolith for capillary electrochromatography
作者: Wei Ze-Hui; Mu Li-Na; Pang Qian-Qian; Huang Yan-Ping; Liu Zhao-Sheng
关键词: CEC ; Chiral separation ; Graft polymerization ; Molecularly imprinted polymer ; Monolithic column
刊名: ELECTROPHORESIS
发表日期: 2012
DOI: 10.1002/elps.201200042
卷: 33, 期:19-20, 页:3021-3027
收录类别: SCI
资助者: National Natural Science Foundation of China 21075090; Chinese Academy of Sciences
摘要: In this paper, a molecularly imprinted polymer (MIP) coating grafted to a trimethylolpropane trimethacrylate (TRIM) core material for CEC was reported. The core monolith was prepared with a solution of 20% (w/w) TRIM in a mixture of porogen and a polymerization precursor, which can generate a stable electroosmotic flow due to the formation of ionizable groups after postpolymerization hydrolization. Graft polymerization took place on the resultant TRIM monolith with a mixture of template, methacrylic acid, and ethylene glycol dimethacrylate. Strong recognition ability (selectivity factor was 5.83) for S-amlodipine and resolution of enatiomers separation (up to 7.99) were obtained on the resulting grafted imprinted monolith in CEC mode. The influence of CEC conditions on chiral separation, including the composition of mobile phase, pH value, and the operating voltages was studied. These results suggest that the method of grafted polymerization reported here allows a rapid development of MIP monolith once core materials with desired properties are available, and is a good alternative to prepare CEC-based monolithic MIPs.
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内容类型: 期刊论文
URI标识: http://ir.xjipc.cas.cn/handle/365002/2763
Appears in Collections:新疆维吾尔自治区植物资源化学重点实验室 _期刊论文

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作者单位: Tianjin Med Univ, Sch Pharm, Tianjin Key Lab Technol Enabling Dev Clin Therape, Tianjin 300070, Peoples R China;Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Zone, Urumqi, Xinjiang, Peoples R China

Recommended Citation:
Wei Ze-Hui,Mu Li-Na,Pang Qian-Qian,et al. Preparation and characterization of grafted imprinted monolith for capillary electrochromatography[J]. ELECTROPHORESIS,2012,33(19-20):3021-3027.
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