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Preparation and characterization of grafted imprinted monolith for capillary electrochromatography
Wei Ze-Hui; Mu Li-Na; Pang Qian-Qian; Huang Yan-Ping; Liu Zhao-Sheng
2012
Source PublicationELECTROPHORESIS
ISSN0173-0835
Volume33Issue:19-20Pages:3021-3027
AbstractIn this paper, a molecularly imprinted polymer (MIP) coating grafted to a trimethylolpropane trimethacrylate (TRIM) core material for CEC was reported. The core monolith was prepared with a solution of 20% (w/w) TRIM in a mixture of porogen and a polymerization precursor, which can generate a stable electroosmotic flow due to the formation of ionizable groups after postpolymerization hydrolization. Graft polymerization took place on the resultant TRIM monolith with a mixture of template, methacrylic acid, and ethylene glycol dimethacrylate. Strong recognition ability (selectivity factor was 5.83) for S-amlodipine and resolution of enatiomers separation (up to 7.99) were obtained on the resulting grafted imprinted monolith in CEC mode. The influence of CEC conditions on chiral separation, including the composition of mobile phase, pH value, and the operating voltages was studied. These results suggest that the method of grafted polymerization reported here allows a rapid development of MIP monolith once core materials with desired properties are available, and is a good alternative to prepare CEC-based monolithic MIPs.
KeywordCec Chiral Separation Graft Polymerization Molecularly Imprinted Polymer Monolithic Column
Subject AreaBiochemistry & Molecular Biology ; Chemistry
DOI10.1002/elps.201200042
Indexed BySCI
WOS IDWOS:000310289600011
Citation statistics
Cited Times:11[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.xjipc.cas.cn/handle/365002/2763
Collection省部共建新疆特有药用资源利用重点实验室
AffiliationTianjin Med Univ, Sch Pharm, Tianjin Key Lab Technol Enabling Dev Clin Therape, Tianjin 300070, Peoples R China;Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Zone, Urumqi, Xinjiang, Peoples R China
Recommended Citation
GB/T 7714
Wei Ze-Hui,Mu Li-Na,Pang Qian-Qian,et al. Preparation and characterization of grafted imprinted monolith for capillary electrochromatography[J]. ELECTROPHORESIS,2012,33(19-20):3021-3027.
APA Wei Ze-Hui,Mu Li-Na,Pang Qian-Qian,Huang Yan-Ping,&Liu Zhao-Sheng.(2012).Preparation and characterization of grafted imprinted monolith for capillary electrochromatography.ELECTROPHORESIS,33(19-20),3021-3027.
MLA Wei Ze-Hui,et al."Preparation and characterization of grafted imprinted monolith for capillary electrochromatography".ELECTROPHORESIS 33.19-20(2012):3021-3027.
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