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学科主题: Pharmacology & Pharmacy ; Chemistry
题名: conformational analysis of yvae peptide derivatives
作者: Pak V. V.; Kwon D. Y.; Yun L. M.; Yili A.; Aisa H. A.; Shakhidoyatov Kh M.
关键词: peptide ; inhibitor ; HMG-CoA reductase ; circular dichroism ; statins
刊名: CHEMISTRY OF NATURAL COMPOUNDS
发表日期: 2012
DOI: 10.1007/s10600-012-0399-6
卷: 48, 期:5, 页:848-852
收录类别: SCI
摘要: Active conformations of YVAE peptide derivatives that were competitive inhibitors of 3-hydroxy3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) were determined. A type I beta-turn in N-terminuses of the studied peptides was shown to be present. The steric positioning of active conformations of peptides and statins revealed the structure-function similarity between these compounds. The results agreed with the observed increase of inhibitor activity in the studied series of peptides.
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内容类型: 期刊论文
URI标识: http://ir.xjipc.cas.cn/handle/365002/2756
Appears in Collections:新疆维吾尔自治区植物资源化学重点实验室 _期刊论文

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作者单位: Korea Food Res Inst, Seoul, South Korea;Acad Sci Peoples Republ China, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Reg, Urumqi 830011, Xinjiang, Peoples R China;Uzbek Acad Sci, S Yu Yunusov Inst Chem Plant Subst, Tashkent 700135, Uzbekistan

Recommended Citation:
Pak V. V.,Kwon D. Y.,Yun L. M.,et al. conformational analysis of yvae peptide derivatives[J]. CHEMISTRY OF NATURAL COMPOUNDS,2012,48(5):848-852.
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文件名: conformational analysis of yvae peptide derivatives.pdf
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