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conformational analysis of yvae peptide derivatives
Pak V. V.; Kwon D. Y.; Yun L. M.; Yili A.; Aisa H. A.; Shakhidoyatov Kh M.
AbstractActive conformations of YVAE peptide derivatives that were competitive inhibitors of 3-hydroxy3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) were determined. A type I beta-turn in N-terminuses of the studied peptides was shown to be present. The steric positioning of active conformations of peptides and statins revealed the structure-function similarity between these compounds. The results agreed with the observed increase of inhibitor activity in the studied series of peptides.
KeywordPeptide Inhibitor Hmg-coa Reductase Circular Dichroism Statins
Subject AreaPharmacology & Pharmacy ; Chemistry
Indexed BySCI
WOS IDWOS:000312061300032
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Document Type期刊论文
AffiliationKorea Food Res Inst, Seoul, South Korea;Acad Sci Peoples Republ China, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Reg, Urumqi 830011, Xinjiang, Peoples R China;Uzbek Acad Sci, S Yu Yunusov Inst Chem Plant Subst, Tashkent 700135, Uzbekistan
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Pak V. V.,Kwon D. Y.,Yun L. M.,et al. conformational analysis of yvae peptide derivatives[J]. CHEMISTRY OF NATURAL COMPOUNDS,2012,48(5):848-852.
APA Pak V. V.,Kwon D. Y.,Yun L. M.,Yili A.,Aisa H. A.,&Shakhidoyatov Kh M..(2012).conformational analysis of yvae peptide derivatives.CHEMISTRY OF NATURAL COMPOUNDS,48(5),848-852.
MLA Pak V. V.,et al."conformational analysis of yvae peptide derivatives".CHEMISTRY OF NATURAL COMPOUNDS 48.5(2012):848-852.
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