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Synthesis of Substituted Thieno [2,3-d]pyrimidin-4-ones and Their Testing for Evaluation of Cytotoxic Activity on Mammalian Cell Models
Bozorov Kh A.; Mamadalieva N. Z.; Elmuradov B. Zh; Triggiani D.; Egamberdieva D.; Tiezzi A.; Aisa H. A.; Shakhidoyatov Kh M.
2013
Source PublicationJOURNAL OF CHEMISTRY
ISSN2090-9063
Volume2013Issue:1
Abstract

From 2-amino-3-ethoxycarbonyl-4,5-dimethyl-, -polymethylenethiopenes (1-4) were synthesized 2,3-disubstituted thieno [2,3-d]dihydropyrrolo-, tetrahydropyrido-, and tetrahydroazepino[1,2-a]pyrimidin-4-ones (5-16) for pharmacological investigations. The 12 compounds (5-16) were individually evaluated for their antiproliferative activities on mammalian cancer cell models. All tested compounds showed weak affection on human cervix adenocarcinoma cells (HeLa) whereas some of the tested compounds exhibited more consistent inhibition of cell growth on murine myeloma cells (P3X). In both cases some compounds enhanced cell proliferation.

Subject AreaChemistry
DOI10.1155/2013/976715
Indexed BySCI
WOS IDWOS:000313195000001
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Document Type期刊论文
Identifierhttp://ir.xjipc.cas.cn/handle/365002/2731
Collection省部共建新疆特有药用资源利用重点实验室
AffiliationS Yu Yunusov Inst Chem Plant Subst AS RUz, Tashkent 100170, Uzbekistan;Univ Tuscia, Largo Univ, Lab Plant Cytol & Biotechnol, Dept Innovat Biol Agrofoods & Forests Syst DIBAF, I-01100 Viterbo, Italy;Natl Univ Uzbekistan, Dept Biotechnol & Microbiol, Tashkent 100174, Uzbekistan;Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Xinjiang Indigenous Med Plants Resource U, Urumqi 830011, Peoples R China
Recommended Citation
GB/T 7714
Bozorov Kh A.,Mamadalieva N. Z.,Elmuradov B. Zh,et al. Synthesis of Substituted Thieno [2,3-d]pyrimidin-4-ones and Their Testing for Evaluation of Cytotoxic Activity on Mammalian Cell Models[J]. JOURNAL OF CHEMISTRY,2013,2013(1).
APA Bozorov Kh A..,Mamadalieva N. Z..,Elmuradov B. Zh.,Triggiani D..,Egamberdieva D..,...&Shakhidoyatov Kh M..(2013).Synthesis of Substituted Thieno [2,3-d]pyrimidin-4-ones and Their Testing for Evaluation of Cytotoxic Activity on Mammalian Cell Models.JOURNAL OF CHEMISTRY,2013(1).
MLA Bozorov Kh A.,et al."Synthesis of Substituted Thieno [2,3-d]pyrimidin-4-ones and Their Testing for Evaluation of Cytotoxic Activity on Mammalian Cell Models".JOURNAL OF CHEMISTRY 2013.1(2013).
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