Synthesis of Substituted Thieno [2,3-d]pyrimidin-4-ones and Their Testing for Evaluation of Cytotoxic Activity on Mammalian Cell Models
Bozorov Kh A.; Mamadalieva N. Z.; Elmuradov B. Zh; Triggiani D.; Egamberdieva D.; Tiezzi A.; Aisa H. A.; Shakhidoyatov Kh M.
2013
发表期刊JOURNAL OF CHEMISTRY
ISSN2090-9063
卷号2013期号:1
摘要

From 2-amino-3-ethoxycarbonyl-4,5-dimethyl-, -polymethylenethiopenes (1-4) were synthesized 2,3-disubstituted thieno [2,3-d]dihydropyrrolo-, tetrahydropyrido-, and tetrahydroazepino[1,2-a]pyrimidin-4-ones (5-16) for pharmacological investigations. The 12 compounds (5-16) were individually evaluated for their antiproliferative activities on mammalian cancer cell models. All tested compounds showed weak affection on human cervix adenocarcinoma cells (HeLa) whereas some of the tested compounds exhibited more consistent inhibition of cell growth on murine myeloma cells (P3X). In both cases some compounds enhanced cell proliferation.

学科领域Chemistry
DOI10.1155/2013/976715
收录类别SCI
WOS记录号WOS:000313195000001
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.xjipc.cas.cn/handle/365002/2731
专题省部共建新疆特有药用资源利用重点实验室
作者单位S Yu Yunusov Inst Chem Plant Subst AS RUz, Tashkent 100170, Uzbekistan;Univ Tuscia, Largo Univ, Lab Plant Cytol & Biotechnol, Dept Innovat Biol Agrofoods & Forests Syst DIBAF, I-01100 Viterbo, Italy;Natl Univ Uzbekistan, Dept Biotechnol & Microbiol, Tashkent 100174, Uzbekistan;Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Xinjiang Indigenous Med Plants Resource U, Urumqi 830011, Peoples R China
推荐引用方式
GB/T 7714
Bozorov Kh A.,Mamadalieva N. Z.,Elmuradov B. Zh,et al. Synthesis of Substituted Thieno [2,3-d]pyrimidin-4-ones and Their Testing for Evaluation of Cytotoxic Activity on Mammalian Cell Models[J]. JOURNAL OF CHEMISTRY,2013,2013(1).
APA Bozorov Kh A..,Mamadalieva N. Z..,Elmuradov B. Zh.,Triggiani D..,Egamberdieva D..,...&Shakhidoyatov Kh M..(2013).Synthesis of Substituted Thieno [2,3-d]pyrimidin-4-ones and Their Testing for Evaluation of Cytotoxic Activity on Mammalian Cell Models.JOURNAL OF CHEMISTRY,2013(1).
MLA Bozorov Kh A.,et al."Synthesis of Substituted Thieno [2,3-d]pyrimidin-4-ones and Their Testing for Evaluation of Cytotoxic Activity on Mammalian Cell Models".JOURNAL OF CHEMISTRY 2013.1(2013).
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Synthesis of Substit(822KB)期刊论文作者接受稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Bozorov Kh A.]的文章
[Mamadalieva N. Z.]的文章
[Elmuradov B. Zh]的文章
百度学术
百度学术中相似的文章
[Bozorov Kh A.]的文章
[Mamadalieva N. Z.]的文章
[Elmuradov B. Zh]的文章
必应学术
必应学术中相似的文章
[Bozorov Kh A.]的文章
[Mamadalieva N. Z.]的文章
[Elmuradov B. Zh]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Synthesis of Substituted Thieno [2,3-d]pyrimidin-4-ones and Their Testing for Evaluation of Cytotoxic Activity on Mammalian Cell Models.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。