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学科主题: Chemistry
题名: Synthesis of Substituted Thieno [2,3-d]pyrimidin-4-ones and Their Testing for Evaluation of Cytotoxic Activity on Mammalian Cell Models
作者: Bozorov Kh A.; Mamadalieva N. Z.; Elmuradov B. Zh; Triggiani D.; Egamberdieva D.; Tiezzi A.; Aisa H. A.; Shakhidoyatov Kh M.
刊名: JOURNAL OF CHEMISTRY
发表日期: 2013
DOI: 10.1155/2013/976715
卷: 2013, 期:1
收录类别: SCI
资助者: Academy of Sciences of the Republic of Uzbekistan FA-F3-T047; National Natural Science Foundation of China 31110103908
摘要:

From 2-amino-3-ethoxycarbonyl-4,5-dimethyl-, -polymethylenethiopenes (1-4) were synthesized 2,3-disubstituted thieno [2,3-d]dihydropyrrolo-, tetrahydropyrido-, and tetrahydroazepino[1,2-a]pyrimidin-4-ones (5-16) for pharmacological investigations. The 12 compounds (5-16) were individually evaluated for their antiproliferative activities on mammalian cancer cell models. All tested compounds showed weak affection on human cervix adenocarcinoma cells (HeLa) whereas some of the tested compounds exhibited more consistent inhibition of cell growth on murine myeloma cells (P3X). In both cases some compounds enhanced cell proliferation.

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内容类型: 期刊论文
URI标识: http://ir.xjipc.cas.cn/handle/365002/2731
Appears in Collections:新疆维吾尔自治区植物资源化学重点实验室 _期刊论文

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作者单位: S Yu Yunusov Inst Chem Plant Subst AS RUz, Tashkent 100170, Uzbekistan;Univ Tuscia, Largo Univ, Lab Plant Cytol & Biotechnol, Dept Innovat Biol Agrofoods & Forests Syst DIBAF, I-01100 Viterbo, Italy;Natl Univ Uzbekistan, Dept Biotechnol & Microbiol, Tashkent 100174, Uzbekistan;Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Xinjiang Indigenous Med Plants Resource U, Urumqi 830011, Peoples R China

Recommended Citation:
Bozorov Kh A.,Mamadalieva N. Z.,Elmuradov B. Zh,et al. Synthesis of Substituted Thieno [2,3-d]pyrimidin-4-ones and Their Testing for Evaluation of Cytotoxic Activity on Mammalian Cell Models[J]. JOURNAL OF CHEMISTRY,2013,2013(1).
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文件名: Synthesis of Substituted Thieno [2,3-d]pyrimidin-4-ones and Their Testing for Evaluation of Cytotoxic Activity on Mammalian Cell Models.pdf
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