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学科主题: Chemistry ; Pharmacology & Pharmacy
题名: Assessment of the estrogenic activities of chickpea (Cicer arietinum L) sprout isoflavone extract in ovariectomized rats
作者: Ma Hai-rong; Wang Jie; Qi Hong-xue; Gao Yan-hua; Pang Li-juan; Yang Yi; Wang Zhen-hua; Duan Ming-jun; Chen Hua; Cao Xu; Aisa Haji Akber
通讯作者: Aisa, HA
关键词: chickpea ; chickpea sprout isoflavone ; phytoestrogen ; 17 beta-estradiol ; ovariectomized rat ; uterine ; follicle stimulating hormone ; luteinizing hormone ; osteoporosis
刊名: ACTA PHARMACOLOGICA SINICA
发表日期: 2013
DOI: 10.1038/aps.2012.160
卷: 34, 期:3, 页:380-386
收录类别: SCI
资助者: China National Funds for Distinguished Young Scientists 30925045; National Natural Science Foundation of China 81102890; CAS/SAFEA International Partnership Program for Creative Research Teams KGCX2-YW-503; Natural Science Foundation of Xinjiang Province, China 2010211A58
摘要: Aim: Chickpea (Cicer arietinum L) is a traditional Uighur herb. In this study we investigated the estrogenic activities of the isoflavones extracted from chickpea sprouts (ICS) in ovariectomized rats. Methods: Ten-week-old virgin Sprague-Dawley female rats were ovariectomized (OVX). The rats were administered via intragastric gavage 3 different doses of ICS (20, 50, or 100 mg.kg(-1).d(-1)) for 5 weeks. Their uterine weight and serum levels of 17 beta-estradiol (E-2), follicle stimulating hormone (FSH) and luteinizing hormone (LH) were measured. The epithelial height, number of glands in the uterus, and number of osteoclasts in the femur were histologically quantified, and the expression of proliferating cell nuclear antigen (PCNA) was assessed immunohistochemically. Bone structural parameters, including bone mineral density (BMD), bone volume/tissue volume (BV/TV), trabecular thickness (Tb.Th) and trabecular separation (Tb.Sp) were measured using Micro-CT scanning. Results: Treatments of OVX rats with ICS (50 or 100 mg.kg(-1).d(-1)) produced significant estrogenic effects on the uteruses, including the increases in uterine weight, epithelial height and gland number, as well as in the expression of the cell proliferation marker PCNA. The treatments changed the secretory profile of ovarian hormones and pituitary gonadotropins: serum E-2 level was significantly increased, while serum LH and FSH levels were decreased compared with the vehicle-treated OVX rats. Furthermore, the treatments significantly attenuated the bone loss, increased BMD, BV/TV and Tb.Th and decreased Tb.Sp and the number of osteoclasts. Treatment of OVX rats with the positive control drug E-2 (0.25 mg.kg(-1).d(-1)) produced similar, but more prominent effects. Conclusion: ICS exhibits moderate estrogenic activities as compared to E-2 in ovariectomized rats, suggesting the potential use of ICS for the treatment of menopausal symptoms and osteoporosis caused by estrogen deficiency.
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内容类型: 期刊论文
URI标识: http://ir.xjipc.cas.cn/handle/365002/2671
Appears in Collections:新疆维吾尔自治区植物资源化学重点实验室 _期刊论文

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作者单位: Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Xinjiang Key Lab Plant Resources & Nat Prod Chem, Urumqi 830011, Peoples R China;Shihezi Univ, Coll Pharm, Minist Educ, Key Lab Xinjiang Endem Phytomed Resources, Shihezi 832002, Peoples R China;Shihezi Univ, Sch Med, Shihezi 832002, Peoples R China;Xinjiang Med Univ, Teaching Hosp 1, Ctr Expt Anim, Urumqi 830011, Peoples R China;Johns Hopkins Univ, Dept Orthopaed Surg, Sch Med, Baltimore, MD 21205 USA

Recommended Citation:
Ma Hai-rong,Wang Jie,Qi Hong-xue,et al. Assessment of the estrogenic activities of chickpea (Cicer arietinum L) sprout isoflavone extract in ovariectomized rats[J]. ACTA PHARMACOLOGICA SINICA,2013,34(3):380-386.
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