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学科主题: Chemistry
题名: Antimicrobial and Antitumor Activities of Crude Extracts and Isolated Compounds from Euphorbia humifusa
作者: Lin Jianbo; Zhao Haiqing; Hang Ba; Aisa Haji Akber
通讯作者: Aisa, HA
关键词: Euphorbia humifusa ; Ethyl acetate extract ; Antimicrobial activity ; Antitumor activity
刊名: ASIAN JOURNAL OF CHEMISTRY
发表日期: 2013
卷: 25, 期:7, 页:3957-3960
收录类别: SCI
资助者: China National Funds for Distinguished Young Scientists 30925045; CAS/SAFEA International Partnership Program for Creative Research Teams
摘要: Euphorbia humifusa Willd. has been used in traditional Chinese medicine. Herein we report the isolation of its constituents and the testing results of their antimicrobial and antitumor activities. The results show that the crude petroleum ether, chloroform, ethyl acetate, butanol and residual methanol fractions exert such activities. Particularly, the crude petroleum ether and ethyl acetate fractions exhibit antigrowth activity against Staphyloccocus aureus with MIC 0.5 mg/mL. Petroleum ether and chloroform fractions significantly exhibit potent antigrowth activity against Caco-2 cells, with IC50 value of 0.059 and 0.025 mg/mL, respectively. The promising bioactivities of the crude petroleum ether fractions guided the first isolation of compounds: 24-methylene cycloartanone (2), dibutyl phthalate (3), hexacosanol (4) and bis-(2-ethylhexyl) phthalate (5) from this species. The antimicrobial activities of compounds 1-2 were evaluated. The tested compounds exhibit potent antigrowth activity against Staphyloccocus aureus, Escherichia coli and Canidia albicans.
内容类型: 期刊论文
URI标识: http://ir.xjipc.cas.cn/handle/365002/2646
Appears in Collections:新疆维吾尔自治区植物资源化学重点实验室 _期刊论文

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作者单位: Chinese Acad Sci, Key Lab Chem Plant Resources Arid Reg, Xinjiang Tech Inst Phys & Chem, Urumqi, Peoples R China

Recommended Citation:
Lin Jianbo,Zhao Haiqing,Hang Ba,et al. Antimicrobial and Antitumor Activities of Crude Extracts and Isolated Compounds from Euphorbia humifusa[J]. ASIAN JOURNAL OF CHEMISTRY,2013,25(7):3957-3960.
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