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Antimicrobial and Antitumor Activities of Crude Extracts and Isolated Compounds from Euphorbia humifusa
Lin Jianbo; Zhao Haiqing; Hang Ba; Aisa Haji Akber
2013
Source PublicationASIAN JOURNAL OF CHEMISTRY
ISSN0970-7077
Volume25Issue:7Pages:3957-3960
Abstract

Euphorbia humifusa Willd. has been used in traditional Chinese medicine. Herein we report the isolation of its constituents and the testing results of their antimicrobial and antitumor activities. The results show that the crude petroleum ether, chloroform, ethyl acetate, butanol and residual methanol fractions exert such activities. Particularly, the crude petroleum ether and ethyl acetate fractions exhibit antigrowth activity against Staphyloccocus aureus with MIC 0.5 mg/mL. Petroleum ether and chloroform fractions significantly exhibit potent antigrowth activity against Caco-2 cells, with IC50 value of 0.059 and 0.025 mg/mL, respectively. The promising bioactivities of the crude petroleum ether fractions guided the first isolation of compounds: 24-methylene cycloartanone (2), dibutyl phthalate (3), hexacosanol (4) and bis-(2-ethylhexyl) phthalate (5) from this species. The antimicrobial activities of compounds 1-2 were evaluated. The tested compounds exhibit potent antigrowth activity against Staphyloccocus aureus, Escherichia coli and Canidia albicans.

KeywordEuphorbia Humifusa Ethyl Acetate Extract Antimicrobial Activity Antitumor Activity
Subject AreaChemistry
Indexed BySCI
WOS IDWOS:000317246300090
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.xjipc.cas.cn/handle/365002/2646
Collection省部共建新疆特有药用资源利用重点实验室
资源化学研究室
Corresponding AuthorAisa Haji Akber
AffiliationChinese Acad Sci, Key Lab Chem Plant Resources Arid Reg, Xinjiang Tech Inst Phys & Chem, Urumqi, Peoples R China
Recommended Citation
GB/T 7714
Lin Jianbo,Zhao Haiqing,Hang Ba,et al. Antimicrobial and Antitumor Activities of Crude Extracts and Isolated Compounds from Euphorbia humifusa[J]. ASIAN JOURNAL OF CHEMISTRY,2013,25(7):3957-3960.
APA Lin Jianbo,Zhao Haiqing,Hang Ba,&Aisa Haji Akber.(2013).Antimicrobial and Antitumor Activities of Crude Extracts and Isolated Compounds from Euphorbia humifusa.ASIAN JOURNAL OF CHEMISTRY,25(7),3957-3960.
MLA Lin Jianbo,et al."Antimicrobial and Antitumor Activities of Crude Extracts and Isolated Compounds from Euphorbia humifusa".ASIAN JOURNAL OF CHEMISTRY 25.7(2013):3957-3960.
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