复合催化剂-酸性阳离子交换树脂/乙醇催化合成5-对羟基苯基乙内酰脲
Alternative Titlesynthesis of 5-(p-hydroxyphenyl) hydantoin using composite catalyst acidic cation-exchange resin/ethanol
朱金刚; 吾满江.艾力; 王永垒; 张乐涛; 李陪军
2010
Source Publication应用化工
ISSN1671-3206
Volume39Issue:6Pages:901-903
Abstract

以复合催化剂酸性阳离子交换树脂/乙醇一步催化合成5-对羟基苯基乙内酰脲,考察了醇的种类及用量、盐酸浓度、反应物摩尔比、反应温度及反应时间对产品收 率的影响。优化的合成工艺为:酸性阳离子交换树脂加入量为反应物总质量的10%,乙醇加入量为40~50 mL/mol乙醛酸,盐酸浓度0.6 mol/L,/n,(乙醛酸):n(苯酚): n(尿素)=1:2:(2~2.5),反应温度90℃,反应时间5~6 h,产品收率可达70%。

Other Abstract

5-(p-Hydroxyphenyl) hydantoin was synthesized using the composite catalyst acidic cation-exchange resin/ethanol. The effect of the amount of ethanol, the concentration of HCl, the molar ratio of reactants, reaction temperature and reaction time on the yield of product were researched. The optimal reaction conditions were as follows: the quantity of the resin is 10% of the total reactant quantity and the quantity of ethanol is 40 ~ 50 mL/mol glyoxylic acid, the concentration of HC1 is 0. 6 mol/L; n( glyoxylic acid) : n(phenol) : n(urea) is 1 :2 : (2 ~2.5) the reaction temperature is 90 ℃ ,the reaction time is 5 ~ 6 h, the yield of final product could reach 70%.

Keyword732阳离子交换树脂 乙醛酸 5-对羟基苯基乙内酰脲
Subject AreaPharmacology & Pharmacy (Provided By Thomson Reuters)
Indexed ByCSCD
CSCD IDCSCD:3893501
Citation statistics
Document Type期刊论文
Identifierhttp://ir.xjipc.cas.cn/handle/365002/2613
Collection新疆维吾尔自治区精细化工工程技术研究中心
Affiliation中国科学院新疆理化技术研究所;中国科学院研究生院
Recommended Citation
GB/T 7714
朱金刚,吾满江.艾力,王永垒,等. 复合催化剂-酸性阳离子交换树脂/乙醇催化合成5-对羟基苯基乙内酰脲[J]. 应用化工,2010,39(6):901-903.
APA 朱金刚,吾满江.艾力,王永垒,张乐涛,&李陪军.(2010).复合催化剂-酸性阳离子交换树脂/乙醇催化合成5-对羟基苯基乙内酰脲.应用化工,39(6),901-903.
MLA 朱金刚,et al."复合催化剂-酸性阳离子交换树脂/乙醇催化合成5-对羟基苯基乙内酰脲".应用化工 39.6(2010):901-903.
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