XJIPC OpenIR  > 资源化学研究室
Hepatoprotective activities of a sesquiterpene-rich fraction from the aerial part of Cichorium glandulosum
Yang, Wei-Jun; Luo, Yu-Qin; Aisa, Haji A; Xin, Xue-Lei; Totahon, Z; Mao, Yan; Hu, Meng-Ying; Xu, Lei; Zhang, Rui-Ping; Aisa, HA
2012
Source PublicationChinese medicine
Volume7Issue:1
AbstractBackground Cichorium glandulosum Boiss. et Huet is used for treatment of liver disorders, and its effects are attributed to sesquiterpenes. This study aims to investigate the hepatoprotective effects of a sesquiterpene-rich fraction (SRF) from the aerial part of C. glandulosum on carbon tetrachloride (CCl4)-induced acute hepatotoxicity in mice, and on priming with Bacillus Calmette–Guerin (BCG) followed by lipopolysaccharide (LPS)-induced immunological liver injury in mice. Methods SRF was suspended in water and administered to mice at 0.05, 0.10 and 0.20 g/kg body weight for 7 consecutive days. An active control drug (bifendate pills) was suspended in distilled water and administered to mice at 0.40 g/kg body weight for 7 consecutive days. Hepatotoxicity was induced by intraperitoneal injection of 0.1% CCl4 (0.2 mL/mouse) at 13 h before the last drug administration, or by tail intravenous injection of BCG (0.2 mL/mouse) before the first drug administration and LPS (0.2 mL/mouse; 8 μg) at 15 h before the last drug administration. Blood samples and the livers were collected for evaluation of the biochemical parameters of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and total bilirubin (TBIL). Results SRF significantly reduced the impact of CCl4 toxicity. The highest dose of SRF (0.20 g/kg) was the most effective, reflected by significant reductions in the levels of AST (P = 0.001), ALT (P = 0.000) and TBIL (P = 0.009). The serum enzymatic levels induced by BCG and subsequent LPS injection were significantly and dose-dependently restored by SRF, reflected by significant reductions in the levels of AST (P = 0.003), ALT (P = 0.003) and TBIL (P = 0.007) for the highest dose of SRF (0.20 g/kg). Conclusion SRF is hepatoprotective in animal models of chemical and immunological acute liver injury.
DOI10.1186/1749-8546-7-21
Indexed BySCI
WOS IDWOS:000320457800001
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.xjipc.cas.cn/handle/365002/2522
Collection资源化学研究室
Corresponding AuthorAisa, HA
AffiliationChinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Xinjiang Key Lab Plant Resources & Nat Prod Chem, Urumqi 830011, Peoples R China;Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China;Xinjiang Inst Mat Med, Xinjiang Key Lab Xinjiang Uygur Med, Urumqi 830004, Peoples R China
Recommended Citation
GB/T 7714
Yang, Wei-Jun,Luo, Yu-Qin,Aisa, Haji A,et al. Hepatoprotective activities of a sesquiterpene-rich fraction from the aerial part of Cichorium glandulosum[J]. Chinese medicine,2012,7(1).
APA Yang, Wei-Jun.,Luo, Yu-Qin.,Aisa, Haji A.,Xin, Xue-Lei.,Totahon, Z.,...&Aisa, HA.(2012).Hepatoprotective activities of a sesquiterpene-rich fraction from the aerial part of Cichorium glandulosum.Chinese medicine,7(1).
MLA Yang, Wei-Jun,et al."Hepatoprotective activities of a sesquiterpene-rich fraction from the aerial part of Cichorium glandulosum".Chinese medicine 7.1(2012).
Files in This Item:
File Name/Size DocType Version Access License
Hepatoprotective act(1068KB)期刊论文作者接受稿开放获取CC BY-NC-SAView Application Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Yang, Wei-Jun]'s Articles
[Luo, Yu-Qin]'s Articles
[Aisa, Haji A]'s Articles
Baidu academic
Similar articles in Baidu academic
[Yang, Wei-Jun]'s Articles
[Luo, Yu-Qin]'s Articles
[Aisa, Haji A]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Yang, Wei-Jun]'s Articles
[Luo, Yu-Qin]'s Articles
[Aisa, Haji A]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Hepatoprotective activities of a sesquiterpene-rich fraction from the aerial part of Cichorium glandulosum.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.