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Hepatoprotective activities of a sesquiterpene-rich fraction from the aerial part of Cichorium glandulosum
Yang, Wei-Jun; Luo, Yu-Qin; Aisa, Haji A; Xin, Xue-Lei; Totahon, Z; Mao, Yan; Hu, Meng-Ying; Xu, Lei; Zhang, Rui-Ping; Aisa, HA
2012
发表期刊Chinese medicine
卷号7期号:1
摘要Background Cichorium glandulosum Boiss. et Huet is used for treatment of liver disorders, and its effects are attributed to sesquiterpenes. This study aims to investigate the hepatoprotective effects of a sesquiterpene-rich fraction (SRF) from the aerial part of C. glandulosum on carbon tetrachloride (CCl4)-induced acute hepatotoxicity in mice, and on priming with Bacillus Calmette–Guerin (BCG) followed by lipopolysaccharide (LPS)-induced immunological liver injury in mice. Methods SRF was suspended in water and administered to mice at 0.05, 0.10 and 0.20 g/kg body weight for 7 consecutive days. An active control drug (bifendate pills) was suspended in distilled water and administered to mice at 0.40 g/kg body weight for 7 consecutive days. Hepatotoxicity was induced by intraperitoneal injection of 0.1% CCl4 (0.2 mL/mouse) at 13 h before the last drug administration, or by tail intravenous injection of BCG (0.2 mL/mouse) before the first drug administration and LPS (0.2 mL/mouse; 8 μg) at 15 h before the last drug administration. Blood samples and the livers were collected for evaluation of the biochemical parameters of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and total bilirubin (TBIL). Results SRF significantly reduced the impact of CCl4 toxicity. The highest dose of SRF (0.20 g/kg) was the most effective, reflected by significant reductions in the levels of AST (P = 0.001), ALT (P = 0.000) and TBIL (P = 0.009). The serum enzymatic levels induced by BCG and subsequent LPS injection were significantly and dose-dependently restored by SRF, reflected by significant reductions in the levels of AST (P = 0.003), ALT (P = 0.003) and TBIL (P = 0.007) for the highest dose of SRF (0.20 g/kg). Conclusion SRF is hepatoprotective in animal models of chemical and immunological acute liver injury.
DOI10.1186/1749-8546-7-21
收录类别SCI
WOS记录号WOS:000320457800001
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被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.xjipc.cas.cn/handle/365002/2522
专题资源化学研究室
通讯作者Aisa, HA
作者单位Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Xinjiang Key Lab Plant Resources & Nat Prod Chem, Urumqi 830011, Peoples R China;Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China;Xinjiang Inst Mat Med, Xinjiang Key Lab Xinjiang Uygur Med, Urumqi 830004, Peoples R China
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Yang, Wei-Jun,Luo, Yu-Qin,Aisa, Haji A,et al. Hepatoprotective activities of a sesquiterpene-rich fraction from the aerial part of Cichorium glandulosum[J]. Chinese medicine,2012,7(1).
APA Yang, Wei-Jun.,Luo, Yu-Qin.,Aisa, Haji A.,Xin, Xue-Lei.,Totahon, Z.,...&Aisa, HA.(2012).Hepatoprotective activities of a sesquiterpene-rich fraction from the aerial part of Cichorium glandulosum.Chinese medicine,7(1).
MLA Yang, Wei-Jun,et al."Hepatoprotective activities of a sesquiterpene-rich fraction from the aerial part of Cichorium glandulosum".Chinese medicine 7.1(2012).
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