XJIPC OpenIR  > 资源化学研究室
Thesis Advisor阿布力米提·伊力、阿吉艾克拜尔·艾萨
Degree Grantor中国科学院大学
Place of Conferral北京
Degree Discipline有机化学
Keyword复方巴甘颗粒 制备工艺 质量标准 巴旦仁 指纹图谱
Other Abstract


依照处方中各味药材所含不同成分的药理作用、理化性质,结合处方的功能主治,拟定用水提取。以甘草酸含量、总多糖含量和水浸出物量为评价指标,选取加水倍量、提取次数和提取时间作为考察因素,通过单因素和正交试验,确定最佳水提取工艺为:加15倍量水,提取3次,每次1.5小时。然后,以甘草酸含量、总多糖含量和水浸出物量为考察指标,结合实验数据和实际工业化生产的条件确定浓缩、纯化工艺条件为:将提取液浓缩至生药:药液(g/mL)为1:10时,以8000 rpm高速离心15分钟。最后,以吸湿率、成型率和溶化性作为评价指标,对辅料的种类、配比和湿润剂乙醇的浓度进行了筛选,确定成型工艺条件为:干浸膏粉与乳糖(1:1.5)混匀,用45%乙醇润湿,制成颗粒。该制备工艺路线合理、简单可行。



; The Fufang Bagan granule comes from Shache Uygur medicine hospital inXinjiang province, and is consist of five kinds of herbs, which are Amygdalus communis ,Cyonia obonga, Cordia dichotoma, Glycyrrhiza uralensis and Pinus gerardiana. Because the original process route is simple, and there is no corresponding standard can control the quality, according to the requirement of Chinese medicine research and methods, the following systematic and comprehensive researches have been conducted: the drafting of preparation process and the drawing up of the quality stander. At the same time, to effectively control the quality of almonds, the fingerprint on the fatty acid composition in almonds has been studied. Regard to the the physiochemical property of the effective components, as well as the main action of the whole recipe, a plan of extracting technology has been made. Using single factor and orthogonal design to optimize the water extraction technology, and with the multiple water, the extraction times and the extraction time as the facors, the best extraction process was determined as follows: adding 15 times water, extracting 3 times and each time for 1.5 hours. Then, with the content of glycyrrhizic acid, the content of total polysaccharide and water extracts as the evaluation index, and combined with the experimental data and the actual production conditions, the process of concentration and purification was determined as follows: the extract was concentrated to the proportion of rude herb and concentration liquid (g/mL) as 1:10; the concentaction was purified by the speed of 8000rpm, 15 minutes. Finally, with hydroscopicity, formability and solubility as the indexes, molding process conditions were determined as follows: dry extract powder and lactose were mixed in proportion of 1:1.5, with 45% ethanol as wetting agent. The preparation process is reasonable, simple and feasible. The study of the quality standard control includes of the examination of the granule's character, TLC and determination of content. The method of TLC identification for Amygdalus communis,Glycyrrhiza uralensis and simultaneous determination of glycyrrhizic acid and liquiritin in Fufang Bagan Granule by HPLC were established.These methods were simple, accurate, reproducible and can be used for quality control of Fufang Bagan Granule. This paper also studied the fatty acid composition of 12 almond samples using GC-MS technology, and established the fingerprint of fatty acid composition in almonds, and the similarity evaluation and cluster analysis of dates were made by “Similarity evaluation system for chromatographic fingerprint of TCM(Version 2004 A)” and “Statistical Product and Service Solutions(SPSS )” software. The fingerprint has 10 common peaks, and has good precision, repeatability and stability. The similarity of fatty acid composition of the 12 samples was above 0.98. Experimental results show that the establishment of the fingerprint can provide a theoretical reference for quality control of the almond and its products.
Document Type学位论文
Recommended Citation
GB/T 7714
徐江玲. 复方巴甘颗粒的制备及巴旦仁脂肪酸指纹图谱研究[D]. 北京. 中国科学院大学,2013.
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