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Thesis Advisor阿吉艾克拜尔·艾萨
Degree Grantor中国科学院大学
Place of Conferral北京
Degree Discipline有机化学
Keyword对叶大戟 大环二萜类化合物 生物活性 维吾尔药
Other Abstract

对叶大戟(Euphorbia sororiaA. Schrenk)是大戟科大戟属一年生草本植物,现主要分布于中亚与新疆田等地。对叶大戟是传统的维吾尔药材,具有利水消肿,镇咳平喘,燥湿开胃,健脑益智的作用。临床用于治疗腹胀胃弱,皮肤疾病和语言不利等疾病。



Euphorbia sororia A. Schrenk belongs to the euphorbia genus of the euphorbiaceae family, which is widely distributed in Central Asian and Hetian of Xinjiang Uighur Autonomous Regon. E. sororia, an annual herb, is traditional Uyghur medicinal herbs to cure abdominal pain, abdominal distention, skin disease, and paralysis. Macrocyclic diterpenes are the main bioactive constituents in the euphorbia genus. They exhibited multi-drug resistance reversal activity, antiproliferative activity, anti-HIV activity and so on. Previous phytochemical inveatigations on E. sororia yielded nine macrocyclic diterpenes. In the course of our investigation on this plant, ten compounds were isolated by different means, such as silica gel column, sephadex LH-20 and preparation HPLC. All the compounds were identified by MS and NMR spectral data. Among them, six new macrocyclic diterpenes (compounds 1-6) and two known macrocyclic diterpenes (compounds 7-8) were first isolated from this plant. Compounds 1-7 were assayed for their antiproferative activity in four human cancer cell lines, and they were inactive for all the cell lines. The multidrug-resistance-reversing activity was investigated on Kbv200 cells. Compound 2 displayed a strong multidrug-resistance-reversing activity. Preliminary structure activity relationship data are discussed. Key word: Euphorbia sororia, Macrocyclic Diterpene, Bioactivity, Uighur Medicine
Document Type学位论文
Recommended Citation
GB/T 7714
陆东礼. 对叶大戟中大环二萜类成分分离分析研究[D]. 北京. 中国科学院大学,2013.
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