中国科学院新疆理化技术研究所机构知识库
Advanced  
XJIPC OpenIR  > 省部共建新疆特有药用资源利用重点实验室  > 期刊论文
学科主题: Chemistry
题名: Investigating the Antioxidant and Acetylcholinesterase Inhibition Activities of Gossypium herbaceam
作者: Zhao, YX (Zhao, Yongxin); Dou, J (Dou, Jun); Wu, T (Wu, Tao); Aisa, HA (Aisa, Haji Akber)
通讯作者: Aisa, HA
关键词: Gossypium herbaceam ; antioxidant activity ; Alzheimer’s disease ; flavonoid
刊名: MOLECULES
发表日期: 2013
DOI: 10.3390/molecules18010951
卷: 18, 期:1, 页:951-962
收录类别: SCI
资助者: This work was financially supported by the Natural Science Foundation of autonomous region, Xinjiang (200821157) and National Natural Sciences Foundation of China (30873455) and National Key Technology R&D Program (2007BAI30B02).
摘要: Our previous research showed that standardized extract from the flowers of the Gossypium herbaceam labeled GHE had been used in clinical trials for its beneficial effects on brain functions, particularly in connection with age-related dementia and Alzheimer's disease (AD). The aim of this work was to determine the components of this herb and the individual constituents of GHE. In order to better understand this herb for AD treatment, we investigated the acetylcholinesterase (AChE) inhibition and antioxidant activity of GHE as well as the protective effects to PC12 cells against cytotoxicity induced by tertiary butyl hydroperoxide (tBHP) using in vitro assays. The antioxidant activities were assessed by measuring their capabilities for scavenging 1,1-diphenyl-2-picylhydrazyl (DPPH) and 2-2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) free radical as well as in inhibiting lipid peroxidation. Our data showed that GHE exhibited certain activities against AChE and also is an efficient free radical scavenger, which may be helpful in preventing or alleviating patients suffering from AD.
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.xjipc.cas.cn/handle/365002/2446
Appears in Collections:新疆维吾尔自治区植物资源化学重点实验室 _期刊论文

Files in This Item:
File Name/ File Size Content Type Version Access License
Investigating the Antioxidant and Acetylcholinesterase Inhibition Activities of Gossypium herbaceam.pdf(257KB)期刊论文作者接受稿开放获取View 联系获取全文

作者单位: Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Xinjiang Key Lab Plant Resources & Nat Prod Chem, Urumqi 830011, Peoples R China;Univ Chinese Acad Sci, Beijing 100039, Peoples R China

Recommended Citation:
Zhao, YX ,Dou, J ,Wu, T ,et al. Investigating the Antioxidant and Acetylcholinesterase Inhibition Activities of Gossypium herbaceam[J]. MOLECULES,2013,18(1):951-962.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zhao, YX (Zhao, Yongxin)]'s Articles
[Dou, J (Dou, Jun)]'s Articles
[Wu, T (Wu, Tao)]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zhao, YX (Zhao, Yongxin)]‘s Articles
[Dou, J (Dou, Jun)]‘s Articles
[Wu, T (Wu, Tao)]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: Investigating the Antioxidant and Acetylcholinesterase Inhibition Activities of Gossypium herbaceam.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace