XJIPC OpenIR  > 省部共建新疆特有药用资源利用重点实验室
Investigating the Antioxidant and Acetylcholinesterase Inhibition Activities of Gossypium herbaceam
Zhao, YX (Zhao, Yongxin); Dou, J (Dou, Jun); Wu, T (Wu, Tao); Aisa, HA (Aisa, Haji Akber); Aisa, HA
2013
Source PublicationMOLECULES
ISSN1466-8033
Volume18Issue:1Pages:951-962
Abstract

Our previous research showed that standardized extract from the flowers of the Gossypium herbaceam labeled GHE had been used in clinical trials for its beneficial effects on brain functions, particularly in connection with age-related dementia and Alzheimer's disease (AD). The aim of this work was to determine the components of this herb and the individual constituents of GHE. In order to better understand this herb for AD treatment, we investigated the acetylcholinesterase (AChE) inhibition and antioxidant activity of GHE as well as the protective effects to PC12 cells against cytotoxicity induced by tertiary butyl hydroperoxide (tBHP) using in vitro assays. The antioxidant activities were assessed by measuring their capabilities for scavenging 1,1-diphenyl-2-picylhydrazyl (DPPH) and 2-2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) free radical as well as in inhibiting lipid peroxidation. Our data showed that GHE exhibited certain activities against AChE and also is an efficient free radical scavenger, which may be helpful in preventing or alleviating patients suffering from AD.

KeywordGossypium Herbaceam Antioxidant Activity Alzheimer’s Disease Flavonoid
Subject AreaChemistry
DOI10.3390/molecules18010951
Indexed BySCI
WOS IDWOS:000314032900059
Citation statistics
Cited Times:33[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.xjipc.cas.cn/handle/365002/2446
Collection省部共建新疆特有药用资源利用重点实验室
Corresponding AuthorAisa, HA
AffiliationChinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Xinjiang Key Lab Plant Resources & Nat Prod Chem, Urumqi 830011, Peoples R China;Univ Chinese Acad Sci, Beijing 100039, Peoples R China
Recommended Citation
GB/T 7714
Zhao, YX ,Dou, J ,Wu, T ,et al. Investigating the Antioxidant and Acetylcholinesterase Inhibition Activities of Gossypium herbaceam[J]. MOLECULES,2013,18(1):951-962.
APA Zhao, YX ,Dou, J ,Wu, T ,Aisa, HA ,&Aisa, HA.(2013).Investigating the Antioxidant and Acetylcholinesterase Inhibition Activities of Gossypium herbaceam.MOLECULES,18(1),951-962.
MLA Zhao, YX ,et al."Investigating the Antioxidant and Acetylcholinesterase Inhibition Activities of Gossypium herbaceam".MOLECULES 18.1(2013):951-962.
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