Investigating the Antioxidant and Acetylcholinesterase Inhibition Activities of Gossypium herbaceam
Zhao, YX (Zhao, Yongxin); Dou, J (Dou, Jun); Wu, T (Wu, Tao); Aisa, HA (Aisa, Haji Akber); Aisa, HA
2013
发表期刊MOLECULES
ISSN1466-8033
卷号18期号:1页码:951-962
摘要

Our previous research showed that standardized extract from the flowers of the Gossypium herbaceam labeled GHE had been used in clinical trials for its beneficial effects on brain functions, particularly in connection with age-related dementia and Alzheimer's disease (AD). The aim of this work was to determine the components of this herb and the individual constituents of GHE. In order to better understand this herb for AD treatment, we investigated the acetylcholinesterase (AChE) inhibition and antioxidant activity of GHE as well as the protective effects to PC12 cells against cytotoxicity induced by tertiary butyl hydroperoxide (tBHP) using in vitro assays. The antioxidant activities were assessed by measuring their capabilities for scavenging 1,1-diphenyl-2-picylhydrazyl (DPPH) and 2-2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) free radical as well as in inhibiting lipid peroxidation. Our data showed that GHE exhibited certain activities against AChE and also is an efficient free radical scavenger, which may be helpful in preventing or alleviating patients suffering from AD.

关键词Gossypium Herbaceam Antioxidant Activity Alzheimer’s Disease Flavonoid
学科领域Chemistry
DOI10.3390/molecules18010951
收录类别SCI
WOS记录号WOS:000314032900059
引用统计
被引频次:27[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.xjipc.cas.cn/handle/365002/2446
专题省部共建新疆特有药用资源利用重点实验室
通讯作者Aisa, HA
作者单位Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Xinjiang Key Lab Plant Resources & Nat Prod Chem, Urumqi 830011, Peoples R China;Univ Chinese Acad Sci, Beijing 100039, Peoples R China
推荐引用方式
GB/T 7714
Zhao, YX ,Dou, J ,Wu, T ,et al. Investigating the Antioxidant and Acetylcholinesterase Inhibition Activities of Gossypium herbaceam[J]. MOLECULES,2013,18(1):951-962.
APA Zhao, YX ,Dou, J ,Wu, T ,Aisa, HA ,&Aisa, HA.(2013).Investigating the Antioxidant and Acetylcholinesterase Inhibition Activities of Gossypium herbaceam.MOLECULES,18(1),951-962.
MLA Zhao, YX ,et al."Investigating the Antioxidant and Acetylcholinesterase Inhibition Activities of Gossypium herbaceam".MOLECULES 18.1(2013):951-962.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Investigating the An(257KB)期刊论文作者接受稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhao, YX (Zhao, Yongxin)]的文章
[Dou, J (Dou, Jun)]的文章
[Wu, T (Wu, Tao)]的文章
百度学术
百度学术中相似的文章
[Zhao, YX (Zhao, Yongxin)]的文章
[Dou, J (Dou, Jun)]的文章
[Wu, T (Wu, Tao)]的文章
必应学术
必应学术中相似的文章
[Zhao, YX (Zhao, Yongxin)]的文章
[Dou, J (Dou, Jun)]的文章
[Wu, T (Wu, Tao)]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Investigating the Antioxidant and Acetylcholinesterase Inhibition Activities of Gossypium herbaceam.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。