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罗勒籽脂肪酸及其对蛋白酪氨酸磷酸酯酶1B(PTP1B)抑制作用的研究
胡尔西丹·伊麻木; 马庆苓; 阿布力米提·伊力; 热娜·卡斯木; 阿吉艾克拜尔·艾萨
2012
Source Publication天然产物研究与开发
ISSN1001-6880
Volume24Issue:9Pages:1261-1263+1302
Abstract

利用索氏提取法提取罗勒籽油,向罗勒籽油加入氢氧化钾甲醇溶液后并用水浴加热,加入正己烷和蒸馏水萃取,上清液即为罗勒籽油中脂肪酸,用气相色谱质谱法(GC/MS)对脂肪酸进行鉴定。共鉴定出了4种脂肪酸,其中α-亚麻酸为62.88%、亚油酸为20.66%、棕榈酸为10.67%、硬脂酸为5.79%。对罗勒籽脂肪酸进行PTP1B的抑制作用研究,结果表明脂肪酸对PTP1B有较强的抑制作用,其IC50为11.12μg/mL。该研究为深入研究罗勒籽的药理作用提供了科学依据。

Other Abstract

Fats and oil were extracted by Soxhlet extraction from the seeds of Ocimum basilicum L. . And then fats and oil were dissolved in KOH of methonal with water-bath. Lastly,the fatty acids were extracted with n-hexane. The chemical constituents of the fatty acids were identified and quantified by means of capillary gas chromatography combined gas Chromatography-mass spectrometry. The results indicated that the fatty acids included four kinds of fatty acids: α-linolenic acid ( 62. 88%) ,linoleic acid ( 20. 66%) ,hexadecanoic acid ( 10. 67%) and octadecanoic acid ( 5. 79%) . The fatty acids had strong inhibiting effect on PTP1B with IC50 value of 11. 12 μg /mL. The results provided the basis for further study of the seeds of O. basilicum.

Keyword罗勒籽 脂肪酸 气相色谱/质谱 Ptp1b抑制作用
Indexed ByCSCD
CSCD IDCSCD:4746949
Citation statistics
Cited Times:1[CSCD]   [CSCD Record]
Document Type期刊论文
Identifierhttp://ir.xjipc.cas.cn/handle/365002/2441
Collection资源化学研究室
Affiliation中国科学院新疆理化技术研究所;中国科学院研究生院;新疆医科大学药学院
Recommended Citation
GB/T 7714
胡尔西丹·伊麻木,马庆苓,阿布力米提·伊力,等. 罗勒籽脂肪酸及其对蛋白酪氨酸磷酸酯酶1B(PTP1B)抑制作用的研究[J]. 天然产物研究与开发,2012,24(9):1261-1263+1302.
APA 胡尔西丹·伊麻木,马庆苓,阿布力米提·伊力,热娜·卡斯木,&阿吉艾克拜尔·艾萨.(2012).罗勒籽脂肪酸及其对蛋白酪氨酸磷酸酯酶1B(PTP1B)抑制作用的研究.天然产物研究与开发,24(9),1261-1263+1302.
MLA 胡尔西丹·伊麻木,et al."罗勒籽脂肪酸及其对蛋白酪氨酸磷酸酯酶1B(PTP1B)抑制作用的研究".天然产物研究与开发 24.9(2012):1261-1263+1302.
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