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GPER:雌激素相关疾病治疗的新靶点
王洁; 阿吉艾克拜尔·艾萨; 马海蓉; 王振华
2013
Source Publication上海交通大学学报(医学版)
ISSN0258-5898
Volume33Issue:2Pages:225-230
Abstract

G蛋白耦联雌激素受体(GPER)是一种G蛋白偶联受体家族的新型雌激素受体,可与雌二醇等雌激素结合,但其信号途径及作用机制与经典核雌激素受体(ERα和ERβ)不同,是一种既能够介导非基因型快速反应也可通过第二信使系统发挥间接转录调控作用的膜性受体。由于GPER可能与雌激素相关疾病的发生、发展密切相关,很可能成为治疗相关疾病的新靶点,近年来备受关注。本文就GPER的发现、结构、亚细胞定位、配体、信号转导途径及与相关疾病之间的关系等方面进行阐述。

Other Abstract

G protein-coupled estrogen receptor 1 ( GPER) is a novel receptor, which belongs to the family of G proteincoupled receptors, to many of the rapid biological responses to estrogen. Different from the two classical nuclear estrogen receptors, ERα and ERβ, GPER modulates both rapid non-genomic reaction and genomic transcriptional events of estrogen. In this regard, GPER may be considered as a valuable target toward novel therapeutic strategy for many estrogen-related diseases. The intrinsic appearance of GPER, including structure, subcellular localization, ligands, signal transduction pathway and relationship with diseases is reviewed in this paper.

KeywordG蛋白偶联雌激素受体 基因表达 肿瘤
Indexed ByCSCD
CSCD IDCSCD:4778124
Citation statistics
Document Type期刊论文
Identifierhttp://ir.xjipc.cas.cn/handle/365002/2405
Collection省部共建新疆特有药用资源利用重点实验室
资源化学研究室
Affiliation石河子大学药学院新疆特种植物药资源教育部重点实验室; 中国科学院新疆理化技术研究所干旱地区植物资源化学重点实验室
Recommended Citation
GB/T 7714
王洁,阿吉艾克拜尔·艾萨,马海蓉,等. GPER:雌激素相关疾病治疗的新靶点[J]. 上海交通大学学报(医学版),2013,33(2):225-230.
APA 王洁,阿吉艾克拜尔·艾萨,马海蓉,&王振华.(2013).GPER:雌激素相关疾病治疗的新靶点.上海交通大学学报(医学版),33(2),225-230.
MLA 王洁,et al."GPER:雌激素相关疾病治疗的新靶点".上海交通大学学报(医学版) 33.2(2013):225-230.
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