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A gluco corticoid-induced leucine-zipper protein, GILZ, inhibits adipogenesis of mesenchymal cells
Shi XM; Shi WB; Li QN; Song B; Wan M; Bai ST; Cao X
2003
发表期刊EMBO REPORTS
ISSN1469-221X
卷号4期号:4页码:374-380
摘要Mesenchymal stem cells have the potential to differentiate into different cell lineages, including adipocytes and osteoblasts. The induction of adipocyte differentiation by glucocorticoids (GCs) not only causes the accumulation of fat cells in bone marrow, but also depletes the supply of osteoblasts for new bone formation, thus leading to osteoporosis. We have shown that a GC-induced leucine-zipper protein (GILZ) antagonizes adipocyte differentiation. GILZ binds to a tandem repeat of CCAAT/enhancer-binding protein (C/EBP) binding sites in the promoter of the gene encoding peroxisome-proliferator-activated receptor-gamma2 (PPAR-gamma2), and inhibits its transcription as a sequence-specific transcriptional repressor. We have also shown that ectopic expression of GILZ blocks GC-induced adipocyte differentiation. Furthermore, adipogenic marker genes (for example, those encoding PPAR-gamma2, C/EBP-alpha, lipoprotein lipase and adipsin) are also inhibited by GILZ. Our results reveal a novel GC antagonistic mechanism that has potential therapeutic applications for the inhibition of GC-induced 'adipocyte differentiation.
学科领域Biochemistry & Molecular Biology ; Cell Biology
DOI10.1038/sj.embor.embor805
收录类别SCI
WOS记录号WOS:000182801300010
引用统计
被引频次:86[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.xjipc.cas.cn/handle/365002/2273
专题资源化学研究室
作者单位Univ Alabama, Dept Pathol, Birmingham, AL 35294 USA;Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Urumqi 830011, Xinjiang, Peoples R China
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Shi XM,Shi WB,Li QN,et al. A gluco corticoid-induced leucine-zipper protein, GILZ, inhibits adipogenesis of mesenchymal cells[J]. EMBO REPORTS,2003,4(4):374-380.
APA Shi XM.,Shi WB.,Li QN.,Song B.,Wan M.,...&Cao X.(2003).A gluco corticoid-induced leucine-zipper protein, GILZ, inhibits adipogenesis of mesenchymal cells.EMBO REPORTS,4(4),374-380.
MLA Shi XM,et al."A gluco corticoid-induced leucine-zipper protein, GILZ, inhibits adipogenesis of mesenchymal cells".EMBO REPORTS 4.4(2003):374-380.
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