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学科主题: Biochemistry & Molecular Biology ; Cell Biology
题名: A gluco corticoid-induced leucine-zipper protein, GILZ, inhibits adipogenesis of mesenchymal cells
作者: Shi XM; Shi WB; Li QN; Song B; Wan M; Bai ST; Cao X
刊名: EMBO REPORTS
发表日期: 2003
DOI: 10.1038/sj.embor.embor805
卷: 4, 期:4, 页:374-380
收录类别: SCI
摘要: Mesenchymal stem cells have the potential to differentiate into different cell lineages, including adipocytes and osteoblasts. The induction of adipocyte differentiation by glucocorticoids (GCs) not only causes the accumulation of fat cells in bone marrow, but also depletes the supply of osteoblasts for new bone formation, thus leading to osteoporosis. We have shown that a GC-induced leucine-zipper protein (GILZ) antagonizes adipocyte differentiation. GILZ binds to a tandem repeat of CCAAT/enhancer-binding protein (C/EBP) binding sites in the promoter of the gene encoding peroxisome-proliferator-activated receptor-gamma2 (PPAR-gamma2), and inhibits its transcription as a sequence-specific transcriptional repressor. We have also shown that ectopic expression of GILZ blocks GC-induced adipocyte differentiation. Furthermore, adipogenic marker genes (for example, those encoding PPAR-gamma2, C/EBP-alpha, lipoprotein lipase and adipsin) are also inhibited by GILZ. Our results reveal a novel GC antagonistic mechanism that has potential therapeutic applications for the inhibition of GC-induced 'adipocyte differentiation.
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内容类型: 期刊论文
URI标识: http://ir.xjipc.cas.cn/handle/365002/2273
Appears in Collections:资源化学研究室_期刊论文

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作者单位: Univ Alabama, Dept Pathol, Birmingham, AL 35294 USA;Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Urumqi 830011, Xinjiang, Peoples R China

Recommended Citation:
Shi XM,Shi WB,Li QN,et al. A gluco corticoid-induced leucine-zipper protein, GILZ, inhibits adipogenesis of mesenchymal cells[J]. EMBO REPORTS,2003,4(4):374-380.
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文件名: a gluco corticoid-induced leucine-zipper protein, gilz, inhibits adipogenesis of mesenchymal cells.pdf
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