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A gluco corticoid-induced leucine-zipper protein, GILZ, inhibits adipogenesis of mesenchymal cells
Shi XM; Shi WB; Li QN; Song B; Wan M; Bai ST; Cao X
2003
Source PublicationEMBO REPORTS
ISSN1469-221X
Volume4Issue:4Pages:374-380
Abstract

Mesenchymal stem cells have the potential to differentiate into different cell lineages, including adipocytes and osteoblasts. The induction of adipocyte differentiation by glucocorticoids (GCs) not only causes the accumulation of fat cells in bone marrow, but also depletes the supply of osteoblasts for new bone formation, thus leading to osteoporosis. We have shown that a GC-induced leucine-zipper protein (GILZ) antagonizes adipocyte differentiation. GILZ binds to a tandem repeat of CCAAT/enhancer-binding protein (C/EBP) binding sites in the promoter of the gene encoding peroxisome-proliferator-activated receptor-gamma2 (PPAR-gamma2), and inhibits its transcription as a sequence-specific transcriptional repressor. We have also shown that ectopic expression of GILZ blocks GC-induced adipocyte differentiation. Furthermore, adipogenic marker genes (for example, those encoding PPAR-gamma2, C/EBP-alpha, lipoprotein lipase and adipsin) are also inhibited by GILZ. Our results reveal a novel GC antagonistic mechanism that has potential therapeutic applications for the inhibition of GC-induced 'adipocyte differentiation.

Subject AreaBiochemistry & Molecular Biology ; Cell Biology
DOI10.1038/sj.embor.embor805
Indexed BySCI
WOS IDWOS:000182801300010
Citation statistics
Cited Times:89[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.xjipc.cas.cn/handle/365002/2273
Collection资源化学研究室
AffiliationUniv Alabama, Dept Pathol, Birmingham, AL 35294 USA;Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Urumqi 830011, Xinjiang, Peoples R China
Recommended Citation
GB/T 7714
Shi XM,Shi WB,Li QN,et al. A gluco corticoid-induced leucine-zipper protein, GILZ, inhibits adipogenesis of mesenchymal cells[J]. EMBO REPORTS,2003,4(4):374-380.
APA Shi XM.,Shi WB.,Li QN.,Song B.,Wan M.,...&Cao X.(2003).A gluco corticoid-induced leucine-zipper protein, GILZ, inhibits adipogenesis of mesenchymal cells.EMBO REPORTS,4(4),374-380.
MLA Shi XM,et al."A gluco corticoid-induced leucine-zipper protein, GILZ, inhibits adipogenesis of mesenchymal cells".EMBO REPORTS 4.4(2003):374-380.
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