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题名: A novel tetrafunctional reagent for simultaneous intramolecular and intermolecular cross-linking of bovine hemoglobin
作者: Yun Qiang; He Minglei; Xing Wenchao; Bi Jingxiu; Ma Guanghui; Su Zhiguo
关键词: blood substitute ; bovine hemoglobin ; cross-linking reagent ; modification
刊名: Biotechnology Letters
发表日期: 2004
DOI: 10.1023/B:BILE.0000045633.36744.0d
卷: 26, 期:17, 页:1359-1363
收录类别: SCI
摘要: A novel tetrafunctional reagent, α,γ,α′, γ′-tetra-succinimidyl-hexanediamide-di-glutamate ester (HDG(OSu)4), was successfully synthesized, and a well-defined cross-linked bovine hemoglobin (mainly 128 kDa) was prepared with this reagent. Due to the spatial structure of this cross-linking reagent, the intramolecular and intermolecular cross-linking of bovine hemoglobin was formed simultaneously in one reaction. Although the cross-linked bovine hemoglobin showed a slight decrease in half-saturated O2 pressure value (P50, from 28.1 mm Hg to 21.7 mm Hg) and Hill coefficient (from 2.5 to 2), due to the cross-linkage, it still performed well for O2 delivery.
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内容类型: 期刊论文
URI标识: http://ir.xjipc.cas.cn/handle/365002/2221
Appears in Collections:资源化学研究室_期刊论文

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作者单位: Chinese Acad Sci, Inst Proc Engn, Natl Lab Biochem Engn, Beijing 100080, Peoples R China;Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem

Recommended Citation:
Yun Qiang,He Minglei,Xing Wenchao,et al. A novel tetrafunctional reagent for simultaneous intramolecular and intermolecular cross-linking of bovine hemoglobin[J]. Biotechnology Letters,2004,26(17):1359-1363.
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