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A novel tetrafunctional reagent for simultaneous intramolecular and intermolecular cross-linking of bovine hemoglobin
Yun Qiang; He Minglei; Xing Wenchao; Bi Jingxiu; Ma Guanghui; Su Zhiguo
2004
Source PublicationBiotechnology Letters
ISSN1415492
Volume26Issue:17Pages:1359-1363
AbstractA novel tetrafunctional reagent, α,γ,α′, γ′-tetra-succinimidyl-hexanediamide-di-glutamate ester (HDG(OSu)4), was successfully synthesized, and a well-defined cross-linked bovine hemoglobin (mainly 128 kDa) was prepared with this reagent. Due to the spatial structure of this cross-linking reagent, the intramolecular and intermolecular cross-linking of bovine hemoglobin was formed simultaneously in one reaction. Although the cross-linked bovine hemoglobin showed a slight decrease in half-saturated O2 pressure value (P50, from 28.1 mm Hg to 21.7 mm Hg) and Hill coefficient (from 2.5 to 2), due to the cross-linkage, it still performed well for O2 delivery.
KeywordBlood Substitute Bovine Hemoglobin Cross-linking Reagent Modification
DOI10.1023/B:BILE.0000045633.36744.0d
Indexed BySCI
WOS IDWOS:000225103700008
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.xjipc.cas.cn/handle/365002/2221
Collection资源化学研究室
AffiliationChinese Acad Sci, Inst Proc Engn, Natl Lab Biochem Engn, Beijing 100080, Peoples R China;Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem
Recommended Citation
GB/T 7714
Yun Qiang,He Minglei,Xing Wenchao,et al. A novel tetrafunctional reagent for simultaneous intramolecular and intermolecular cross-linking of bovine hemoglobin[J]. Biotechnology Letters,2004,26(17):1359-1363.
APA Yun Qiang,He Minglei,Xing Wenchao,Bi Jingxiu,Ma Guanghui,&Su Zhiguo.(2004).A novel tetrafunctional reagent for simultaneous intramolecular and intermolecular cross-linking of bovine hemoglobin.Biotechnology Letters,26(17),1359-1363.
MLA Yun Qiang,et al."A novel tetrafunctional reagent for simultaneous intramolecular and intermolecular cross-linking of bovine hemoglobin".Biotechnology Letters 26.17(2004):1359-1363.
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