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Alternative TitleSynthesis of Rupestonic Acid Amide Derivatives and in vitro Anti-influenza A3,B and Herpes Simplex Type Ⅰ and Ⅱ Viruses
雍建平; 阿吉艾克拜尔·艾萨
Source Publication有机化学


Other Abstract

The rupestonic acid (compound 1) was isolated from the Chinese herbal medicine Artemisiarupestris L. (its Chinese name being Yizhihao). Then, 13 rupestonic acid amide derivatives 2a2m weresynthesized using rupestonic acid and organic amines in the presence of DCC, HOBt/DMAP and theirstructures were comfirmed by the methods of IR, 1HNMR, and ESI-MS. All compounds were preliminarilyassayed in vitro against influenza A3, B, herpes simplex I (HSV-I) and herpes simplex II (HSV-II) viruses,showing that 2a was inhibitive to both influenza A3 and B viruses, and had the higher inhibition against influenzaB virus than the parent compound 1. The inhibition of 2d against influenza B virus was 16-foldhigher than that of the parent compound and 2e was more active both to HSV-I and HSV-II viruses .

Keyword合成 一枝蒿酮酸酰胺衍生物 流感病毒 单纯疱疹病毒 活性研究
Indexed BySCI ; CSCD
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Cited Times:6[CSCD]   [CSCD Record]
Document Type期刊论文
Recommended Citation
GB/T 7714
雍建平,阿吉艾克拜尔·艾萨. 一枝蒿酮酸酰胺衍生物的合成和抗A3,B型流感病毒和单纯Ⅰ,Ⅱ型疱疹病毒活性研究[J]. 有机化学,2008,28(10):1807-1812.
APA 雍建平,&阿吉艾克拜尔·艾萨.(2008).一枝蒿酮酸酰胺衍生物的合成和抗A3,B型流感病毒和单纯Ⅰ,Ⅱ型疱疹病毒活性研究.有机化学,28(10),1807-1812.
MLA 雍建平,et al."一枝蒿酮酸酰胺衍生物的合成和抗A3,B型流感病毒和单纯Ⅰ,Ⅱ型疱疹病毒活性研究".有机化学 28.10(2008):1807-1812.
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