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Isolation of three sesquiterpene lactones from the roots of Cichorium glandulosum Boiss. et Huet. by high-speed counter-current chromatography
Wu Hankui; Su Zhen; Yang Yi; Ba Hang; Aisa Haji Akber
2007
Source PublicationJournal of Chromatography A
ISSN0021-9673
Volume1176Issue:1-2Pages:217-222
Abstract

Because of the skeletal complexity and similarity of the polarity, little research was reported on the isolation of sesquiterpene lactones by high-speed counter-current chromatography (HSCCC). Herein, three sesquiterpene lactones were successfully purified from the ethyl acetate extract of the roots of the traditional Uyghur medicinal plant Cichorium glandulosum Boiss. et Huet. by HSCCC. The separation was performed in two steps with two solvent systems: n-hexane-ethyl acetate-methanol-water (1.5:5:2.75:5, v/v/v/v) and ethyl acetate-methanol-water (20:1:20, v/v/v). From 166 mg of the ethyl acetate extract, 19 mg of lactucopicrin was isolated with the first solvent system and 10 mg of 11β,13-dihydrolactucin and 16 mg of lactucin were obtained with the second solvent system. All purified compounds were over 94% purity as determined by HPLC analysis, and these chemical structures were confirmed by 1H NMR and 13C NMR.

KeywordCichorium Glandulosum Hsccc Lactucopicrin 11 Beta 13-dihydrolactucin Lactucin
DOI10.1016/j.chroma.2007.11.013
Indexed BySCI
WOS IDWOS:000251848100026
Citation statistics
Cited Times:35[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.xjipc.cas.cn/handle/365002/2080
Collection资源化学研究室
Corresponding AuthorAisa Haji Akber
AffiliationChinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Xinjiang Key Lab Plant Resources & Nat Prod Chem, Urumqi 830011, Peoples R China;Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
Recommended Citation
GB/T 7714
Wu Hankui,Su Zhen,Yang Yi,et al. Isolation of three sesquiterpene lactones from the roots of Cichorium glandulosum Boiss. et Huet. by high-speed counter-current chromatography[J]. Journal of Chromatography A,2007,1176(1-2):217-222.
APA Wu Hankui,Su Zhen,Yang Yi,Ba Hang,&Aisa Haji Akber.(2007).Isolation of three sesquiterpene lactones from the roots of Cichorium glandulosum Boiss. et Huet. by high-speed counter-current chromatography.Journal of Chromatography A,1176(1-2),217-222.
MLA Wu Hankui,et al."Isolation of three sesquiterpene lactones from the roots of Cichorium glandulosum Boiss. et Huet. by high-speed counter-current chromatography".Journal of Chromatography A 1176.1-2(2007):217-222.
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