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Gossypium herbaceam Extracts Attenuate Ibotenic Acid-induced Excitotoxicity in Rat Hippocampus
Ji Chao; Li Qing; Aisa HajiAkber; Yang Nan; Dong Yi-Long; Liu Yan-Yong; Wang Tao; Hao Qiang; Zhu Hai-Bo; Zuo Ping-Ping
2009
发表期刊JOURNAL OF ALZHEIMERS DISEASE
ISSN1387-2877
卷号16期号:2页码:331-339
摘要Excitotoxicity is one of the most extensively studied processes of neuronal death and plays an important role in Alzheimer's disease. In the present study, the protective effects of Gossypium herbaceam extracts (GHE) on learning and memory impairment induced by excitatory neurotoxin ibotenic acid were examined in vivo using Morris water maze. Furthermore, neuroprotective effects of GHE were investigated with methods of immunohistochemistry and biochemistry. Our data showed that oral administration with GHE at the doses of 35, 70 and 140 mg/kg exerted an improved effect on the learning and memory impairment in rats induced by intracerebral injection of ibotenic acid. To confirm the precise mechanism of memory improvement by presence of GHE, we further investigated the potential protection on the hippocampus. Our findings suggest that GHE afforded a beneficial inhibition on pro-apoptosis proteins expression following ibotenic acid. Additionally, calcium pump activity and calbindin-D28k expression were dramatically increased after GHE treatment, implicating that the modulation of calcium homeostasis could be involved in the mechanism underlying neuroprotection of GHE against ibotenic acid-induced excitotoxicity. These data suggested that GHE could be a potential agent for preventing or retarding the development or progression of Alzheimer's disease.
关键词Alzheimer's Disease Apoptosis Regulatory Proteins Calbindin Gossypium Herbaceam Ibotenic Acid
学科领域Neurosciences & Neurology
DOI10.3233/JAD-2009-0979
收录类别SCI
WOS记录号WOS:000264288800011
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被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.xjipc.cas.cn/handle/365002/1890
专题资源化学研究室
作者单位Chinese Acad Med Sci, Peking Union Med Coll, Sch Basic Med, Dept Pharmacol, Beijing 100005, Peoples R China;Chinese Acad Med Sci, Inst Basic Med Sci, Beijing 100005, Peoples R China;Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Urumqi, Peoples R China;Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China
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Ji Chao,Li Qing,Aisa HajiAkber,et al. Gossypium herbaceam Extracts Attenuate Ibotenic Acid-induced Excitotoxicity in Rat Hippocampus[J]. JOURNAL OF ALZHEIMERS DISEASE,2009,16(2):331-339.
APA Ji Chao.,Li Qing.,Aisa HajiAkber.,Yang Nan.,Dong Yi-Long.,...&Zuo Ping-Ping.(2009).Gossypium herbaceam Extracts Attenuate Ibotenic Acid-induced Excitotoxicity in Rat Hippocampus.JOURNAL OF ALZHEIMERS DISEASE,16(2),331-339.
MLA Ji Chao,et al."Gossypium herbaceam Extracts Attenuate Ibotenic Acid-induced Excitotoxicity in Rat Hippocampus".JOURNAL OF ALZHEIMERS DISEASE 16.2(2009):331-339.
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