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学科主题: Neurosciences & Neurology
题名: Gossypium herbaceam Extracts Attenuate Ibotenic Acid-induced Excitotoxicity in Rat Hippocampus
作者: Ji Chao; Li Qing; Aisa HajiAkber; Yang Nan; Dong Yi-Long; Liu Yan-Yong; Wang Tao; Hao Qiang; Zhu Hai-Bo; Zuo Ping-Ping
关键词: Alzheimer's disease ; apoptosis regulatory proteins ; calbindin ; Gossypium herbaceam ; ibotenic acid
刊名: JOURNAL OF ALZHEIMERS DISEASE
发表日期: 2009
DOI: 10.3233/JAD-2009-0979
卷: 16, 期:2, 页:331-339
收录类别: SCI
摘要: Excitotoxicity is one of the most extensively studied processes of neuronal death and plays an important role in Alzheimer's disease. In the present study, the protective effects of Gossypium herbaceam extracts (GHE) on learning and memory impairment induced by excitatory neurotoxin ibotenic acid were examined in vivo using Morris water maze. Furthermore, neuroprotective effects of GHE were investigated with methods of immunohistochemistry and biochemistry. Our data showed that oral administration with GHE at the doses of 35, 70 and 140 mg/kg exerted an improved effect on the learning and memory impairment in rats induced by intracerebral injection of ibotenic acid. To confirm the precise mechanism of memory improvement by presence of GHE, we further investigated the potential protection on the hippocampus. Our findings suggest that GHE afforded a beneficial inhibition on pro-apoptosis proteins expression following ibotenic acid. Additionally, calcium pump activity and calbindin-D28k expression were dramatically increased after GHE treatment, implicating that the modulation of calcium homeostasis could be involved in the mechanism underlying neuroprotection of GHE against ibotenic acid-induced excitotoxicity. These data suggested that GHE could be a potential agent for preventing or retarding the development or progression of Alzheimer's disease.
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内容类型: 期刊论文
URI标识: http://ir.xjipc.cas.cn/handle/365002/1890
Appears in Collections:资源化学研究室_期刊论文

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作者单位: Chinese Acad Med Sci, Peking Union Med Coll, Sch Basic Med, Dept Pharmacol, Beijing 100005, Peoples R China;Chinese Acad Med Sci, Inst Basic Med Sci, Beijing 100005, Peoples R China;Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Urumqi, Peoples R China;Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China

Recommended Citation:
Ji Chao,Li Qing,Aisa HajiAkber,et al. Gossypium herbaceam Extracts Attenuate Ibotenic Acid-induced Excitotoxicity in Rat Hippocampus[J]. JOURNAL OF ALZHEIMERS DISEASE,2009,16(2):331-339.
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